Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.etap.2021.103727 http://hdl.handle.net/11449/222278 |
Resumo: | The intensive use of the antihypertensive losartan potassium (LOS) has culminated in its high occurrence in aquatic environments. However, insufficient studies had investigated its effects in non-target organisms. In this study, ecotoxicity of LOS was assessed in aquatic organisms from distinct trophic levels (Desmodesmus subspicatus, Daphnia magna, and Astyanax altiparanae). Genotoxicity was assessed by the comet assay in D. magna and A. altiparanae, and biochemical biomarkers for the fish. LOS was more toxic to D. subspicatus (EC50(72h) = 27.93 mg L−1) than D. magna (EC50 = 303.69 mg L−1). Subsequently, this drug showed to induce more DNA damage in D. magna than A. altiparanae, when exposed to 2.5 mg L−1. No significant stress responses were observed by the fish biomarkers, suggesting that higher trophic levels organisms are more tolerant to LOS toxicity. LOS showed relatively low toxic potential for a short period of exposure, but with different patterns of toxicity for the organisms from distinct trophic levels, contributing to further risk assessment of LOS. |
id |
UNSP_ae5fe1ae2d4e0fb3ad85be0834014033 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/222278 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levelsAntihypertensive drugsAquatic organismsBiochemical biomarkersDistinct trophic levelsGenotoxicityThe intensive use of the antihypertensive losartan potassium (LOS) has culminated in its high occurrence in aquatic environments. However, insufficient studies had investigated its effects in non-target organisms. In this study, ecotoxicity of LOS was assessed in aquatic organisms from distinct trophic levels (Desmodesmus subspicatus, Daphnia magna, and Astyanax altiparanae). Genotoxicity was assessed by the comet assay in D. magna and A. altiparanae, and biochemical biomarkers for the fish. LOS was more toxic to D. subspicatus (EC50(72h) = 27.93 mg L−1) than D. magna (EC50 = 303.69 mg L−1). Subsequently, this drug showed to induce more DNA damage in D. magna than A. altiparanae, when exposed to 2.5 mg L−1. No significant stress responses were observed by the fish biomarkers, suggesting that higher trophic levels organisms are more tolerant to LOS toxicity. LOS showed relatively low toxic potential for a short period of exposure, but with different patterns of toxicity for the organisms from distinct trophic levels, contributing to further risk assessment of LOS.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratory of Ecotoxicology Department of Chemistry and Biology Federal University of Technology - ParanáInstitute of Biosciences State University of São PauloResearch Institute Pelé Pequeno PríncipeFaculdades Pequeno PríncipeFAPESP: 2016/15229-1Federal University of Technology - ParanáUniversidade de São Paulo (USP)Research Institute Pelé Pequeno PríncipeFaculdades Pequeno PríncipeReque, RegianeCarneiro, Rhaissa DayaneYamamoto, Flávia YoshieRamsdorf, Wanessa AlgarteMartins, Lucia ReginaGuiloski, Izonete Cristinade Freitas, Adriane Martins2022-04-28T19:43:41Z2022-04-28T19:43:41Z2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.etap.2021.103727Environmental Toxicology and Pharmacology, v. 87.1872-70771382-6689http://hdl.handle.net/11449/22227810.1016/j.etap.2021.1037272-s2.0-85113442423Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Toxicology and Pharmacologyinfo:eu-repo/semantics/openAccess2022-04-28T19:43:41Zoai:repositorio.unesp.br:11449/222278Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:43:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels |
title |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels |
spellingShingle |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels Reque, Regiane Antihypertensive drugs Aquatic organisms Biochemical biomarkers Distinct trophic levels Genotoxicity |
title_short |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels |
title_full |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels |
title_fullStr |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels |
title_full_unstemmed |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels |
title_sort |
Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels |
author |
Reque, Regiane |
author_facet |
Reque, Regiane Carneiro, Rhaissa Dayane Yamamoto, Flávia Yoshie Ramsdorf, Wanessa Algarte Martins, Lucia Regina Guiloski, Izonete Cristina de Freitas, Adriane Martins |
author_role |
author |
author2 |
Carneiro, Rhaissa Dayane Yamamoto, Flávia Yoshie Ramsdorf, Wanessa Algarte Martins, Lucia Regina Guiloski, Izonete Cristina de Freitas, Adriane Martins |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Technology - Paraná Universidade de São Paulo (USP) Research Institute Pelé Pequeno Príncipe Faculdades Pequeno Príncipe |
dc.contributor.author.fl_str_mv |
Reque, Regiane Carneiro, Rhaissa Dayane Yamamoto, Flávia Yoshie Ramsdorf, Wanessa Algarte Martins, Lucia Regina Guiloski, Izonete Cristina de Freitas, Adriane Martins |
dc.subject.por.fl_str_mv |
Antihypertensive drugs Aquatic organisms Biochemical biomarkers Distinct trophic levels Genotoxicity |
topic |
Antihypertensive drugs Aquatic organisms Biochemical biomarkers Distinct trophic levels Genotoxicity |
description |
The intensive use of the antihypertensive losartan potassium (LOS) has culminated in its high occurrence in aquatic environments. However, insufficient studies had investigated its effects in non-target organisms. In this study, ecotoxicity of LOS was assessed in aquatic organisms from distinct trophic levels (Desmodesmus subspicatus, Daphnia magna, and Astyanax altiparanae). Genotoxicity was assessed by the comet assay in D. magna and A. altiparanae, and biochemical biomarkers for the fish. LOS was more toxic to D. subspicatus (EC50(72h) = 27.93 mg L−1) than D. magna (EC50 = 303.69 mg L−1). Subsequently, this drug showed to induce more DNA damage in D. magna than A. altiparanae, when exposed to 2.5 mg L−1. No significant stress responses were observed by the fish biomarkers, suggesting that higher trophic levels organisms are more tolerant to LOS toxicity. LOS showed relatively low toxic potential for a short period of exposure, but with different patterns of toxicity for the organisms from distinct trophic levels, contributing to further risk assessment of LOS. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-01 2022-04-28T19:43:41Z 2022-04-28T19:43:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.etap.2021.103727 Environmental Toxicology and Pharmacology, v. 87. 1872-7077 1382-6689 http://hdl.handle.net/11449/222278 10.1016/j.etap.2021.103727 2-s2.0-85113442423 |
url |
http://dx.doi.org/10.1016/j.etap.2021.103727 http://hdl.handle.net/11449/222278 |
identifier_str_mv |
Environmental Toxicology and Pharmacology, v. 87. 1872-7077 1382-6689 10.1016/j.etap.2021.103727 2-s2.0-85113442423 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environmental Toxicology and Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649971114737664 |