Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery

Detalhes bibliográficos
Autor(a) principal: Rissi, Nathalia Cristina [UNESP]
Data de Publicação: 2014
Outros Autores: Guglielmi, Danila Aparecida Scatolin [UNESP], Corrêa, Marcos Antônio [UNESP], Chiavacci, Leila Aparecida [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/130162
Resumo: In this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks.
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spelling Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug deliveryTernary phase diagramsNanostructured systemsSmall-angle X-ray scattering/profilesDrugs/delivery systemsDiagramas de fases ternáriosSistemas nanoestruturadosCurvas de dispersão de raios X de pequeno ângulo/perfisFármacos/sistemas de liberaçãoIn this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks.Neste trabalho, os sistemas nanoestruturados com diferentes níveis de organização foram obtidos através dos diagramas de fase ternários, utilizando tensoativos com de diferentes graus de lipofilicidade, o PPG-5- Ceteth-20 e o Oleth 10, e ácido oleico e miristato de isopropila como fases oleosas. Através dos diagramas foi possível observar diferenças significativas relacionadas com as características dos sistemas, devido à capacidade que o Oleth 10 (como tensoativo) e o ácido oleico (como fase oleosa) têm em diminuir a tensão interfacial, facilitando a formação de uma extensa região de sistemas transparentes. Através da microscopia de luz polarizada foi possível identificar as características isotrópicas e anisotrópicas dos sistemas, sendo posteriormente confirmadas pelas curvas de dispersão de raios X de pequeno ângulo (SAXS). Além disso, foi possível verificar que o aumento de água nas formulações proporcionou maior estruturação, permitindo a observação de picos mais estreitos e definidos nas curvas de SAXS.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual Paulista, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas de AraraquaraUniv Sao Paulo, Conjunto QuimicasUniversidade Estadual Paulista (Unesp)Rissi, Nathalia Cristina [UNESP]Guglielmi, Danila Aparecida Scatolin [UNESP]Corrêa, Marcos Antônio [UNESP]Chiavacci, Leila Aparecida [UNESP]2015-11-03T15:29:47Z2015-11-03T15:29:47Z2014-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article653-661application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&nrm=iso&tlng=enBrazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 653-661, 2014.1984-8250http://hdl.handle.net/11449/13016210.1590/S1984-82502014000300025S1984-82502014000300653WOS:000345428300025S1984-82502014000300653.pdf3316011688829943Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal Of Pharmaceutical Sciences0.4830,214info:eu-repo/semantics/openAccess2024-06-24T13:45:38Zoai:repositorio.unesp.br:11449/130162Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:10:51.055742Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
title Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
spellingShingle Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
Rissi, Nathalia Cristina [UNESP]
Ternary phase diagrams
Nanostructured systems
Small-angle X-ray scattering/profiles
Drugs/delivery systems
Diagramas de fases ternários
Sistemas nanoestruturados
Curvas de dispersão de raios X de pequeno ângulo/perfis
Fármacos/sistemas de liberação
title_short Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
title_full Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
title_fullStr Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
title_full_unstemmed Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
title_sort Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
author Rissi, Nathalia Cristina [UNESP]
author_facet Rissi, Nathalia Cristina [UNESP]
Guglielmi, Danila Aparecida Scatolin [UNESP]
Corrêa, Marcos Antônio [UNESP]
Chiavacci, Leila Aparecida [UNESP]
author_role author
author2 Guglielmi, Danila Aparecida Scatolin [UNESP]
Corrêa, Marcos Antônio [UNESP]
Chiavacci, Leila Aparecida [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Rissi, Nathalia Cristina [UNESP]
Guglielmi, Danila Aparecida Scatolin [UNESP]
Corrêa, Marcos Antônio [UNESP]
Chiavacci, Leila Aparecida [UNESP]
dc.subject.por.fl_str_mv Ternary phase diagrams
Nanostructured systems
Small-angle X-ray scattering/profiles
Drugs/delivery systems
Diagramas de fases ternários
Sistemas nanoestruturados
Curvas de dispersão de raios X de pequeno ângulo/perfis
Fármacos/sistemas de liberação
topic Ternary phase diagrams
Nanostructured systems
Small-angle X-ray scattering/profiles
Drugs/delivery systems
Diagramas de fases ternários
Sistemas nanoestruturados
Curvas de dispersão de raios X de pequeno ângulo/perfis
Fármacos/sistemas de liberação
description In this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-01
2015-11-03T15:29:47Z
2015-11-03T15:29:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&nrm=iso&tlng=en
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 653-661, 2014.
1984-8250
http://hdl.handle.net/11449/130162
10.1590/S1984-82502014000300025
S1984-82502014000300653
WOS:000345428300025
S1984-82502014000300653.pdf
3316011688829943
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/130162
identifier_str_mv Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 653-661, 2014.
1984-8250
10.1590/S1984-82502014000300025
S1984-82502014000300653
WOS:000345428300025
S1984-82502014000300653.pdf
3316011688829943
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal Of Pharmaceutical Sciences
0.483
0,214
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 653-661
application/pdf
dc.publisher.none.fl_str_mv Univ Sao Paulo, Conjunto Quimicas
publisher.none.fl_str_mv Univ Sao Paulo, Conjunto Quimicas
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
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institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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