Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/130162 |
Resumo: | In this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks. |
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Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug deliveryTernary phase diagramsNanostructured systemsSmall-angle X-ray scattering/profilesDrugs/delivery systemsDiagramas de fases ternáriosSistemas nanoestruturadosCurvas de dispersão de raios X de pequeno ângulo/perfisFármacos/sistemas de liberaçãoIn this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks.Neste trabalho, os sistemas nanoestruturados com diferentes níveis de organização foram obtidos através dos diagramas de fase ternários, utilizando tensoativos com de diferentes graus de lipofilicidade, o PPG-5- Ceteth-20 e o Oleth 10, e ácido oleico e miristato de isopropila como fases oleosas. Através dos diagramas foi possível observar diferenças significativas relacionadas com as características dos sistemas, devido à capacidade que o Oleth 10 (como tensoativo) e o ácido oleico (como fase oleosa) têm em diminuir a tensão interfacial, facilitando a formação de uma extensa região de sistemas transparentes. Através da microscopia de luz polarizada foi possível identificar as características isotrópicas e anisotrópicas dos sistemas, sendo posteriormente confirmadas pelas curvas de dispersão de raios X de pequeno ângulo (SAXS). Além disso, foi possível verificar que o aumento de água nas formulações proporcionou maior estruturação, permitindo a observação de picos mais estreitos e definidos nas curvas de SAXS.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual Paulista, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas de AraraquaraUniv Sao Paulo, Conjunto QuimicasUniversidade Estadual Paulista (Unesp)Rissi, Nathalia Cristina [UNESP]Guglielmi, Danila Aparecida Scatolin [UNESP]Corrêa, Marcos Antônio [UNESP]Chiavacci, Leila Aparecida [UNESP]2015-11-03T15:29:47Z2015-11-03T15:29:47Z2014-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article653-661application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&nrm=iso&tlng=enBrazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 653-661, 2014.1984-8250http://hdl.handle.net/11449/13016210.1590/S1984-82502014000300025S1984-82502014000300653WOS:000345428300025S1984-82502014000300653.pdf3316011688829943Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal Of Pharmaceutical Sciences0.4830,214info:eu-repo/semantics/openAccess2024-06-24T13:45:38Zoai:repositorio.unesp.br:11449/130162Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:10:51.055742Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery |
title |
Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery |
spellingShingle |
Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery Rissi, Nathalia Cristina [UNESP] Ternary phase diagrams Nanostructured systems Small-angle X-ray scattering/profiles Drugs/delivery systems Diagramas de fases ternários Sistemas nanoestruturados Curvas de dispersão de raios X de pequeno ângulo/perfis Fármacos/sistemas de liberação |
title_short |
Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery |
title_full |
Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery |
title_fullStr |
Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery |
title_full_unstemmed |
Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery |
title_sort |
Relationship between composition and organizational levels of nanostructured systems formed by Oleth 10 and PPG-5-Ceteth-20 for potential drug delivery |
author |
Rissi, Nathalia Cristina [UNESP] |
author_facet |
Rissi, Nathalia Cristina [UNESP] Guglielmi, Danila Aparecida Scatolin [UNESP] Corrêa, Marcos Antônio [UNESP] Chiavacci, Leila Aparecida [UNESP] |
author_role |
author |
author2 |
Guglielmi, Danila Aparecida Scatolin [UNESP] Corrêa, Marcos Antônio [UNESP] Chiavacci, Leila Aparecida [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Rissi, Nathalia Cristina [UNESP] Guglielmi, Danila Aparecida Scatolin [UNESP] Corrêa, Marcos Antônio [UNESP] Chiavacci, Leila Aparecida [UNESP] |
dc.subject.por.fl_str_mv |
Ternary phase diagrams Nanostructured systems Small-angle X-ray scattering/profiles Drugs/delivery systems Diagramas de fases ternários Sistemas nanoestruturados Curvas de dispersão de raios X de pequeno ângulo/perfis Fármacos/sistemas de liberação |
topic |
Ternary phase diagrams Nanostructured systems Small-angle X-ray scattering/profiles Drugs/delivery systems Diagramas de fases ternários Sistemas nanoestruturados Curvas de dispersão de raios X de pequeno ângulo/perfis Fármacos/sistemas de liberação |
description |
In this paper, nanostructured systems were developed, with the aid of ternary phase diagrams, from two surfactants, of differing degrees of lipophilicity (PPG-5-Ceteth-20 and the Oleth 10) and two oil phases (oleic acid and isopropyl myristate). It was observed that there were differences between the four resulting phase diagrams in the physical properties of the systems they represent. Thus, due to the capacity of Oleth 10 (as surfactant) and oleic acid (as the oil phase) to reduce interfacial tension, large regions of translucent systems were seen on the diagrams produced by them. By polarized light microscopy, it was possible to identify the isotropic and anisotropic properties of these systems, which were confirmed by small-angle X-ray scattering (SAXS) analysis. Furthermore, it was found that increasing the proportion of water in the formulations led to more highly organized structures, resulting in narrower and well defined SAXS peaks. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07-01 2015-11-03T15:29:47Z 2015-11-03T15:29:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&nrm=iso&tlng=en Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 653-661, 2014. 1984-8250 http://hdl.handle.net/11449/130162 10.1590/S1984-82502014000300025 S1984-82502014000300653 WOS:000345428300025 S1984-82502014000300653.pdf 3316011688829943 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300653&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/130162 |
identifier_str_mv |
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 653-661, 2014. 1984-8250 10.1590/S1984-82502014000300025 S1984-82502014000300653 WOS:000345428300025 S1984-82502014000300653.pdf 3316011688829943 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal Of Pharmaceutical Sciences 0.483 0,214 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
653-661 application/pdf |
dc.publisher.none.fl_str_mv |
Univ Sao Paulo, Conjunto Quimicas |
publisher.none.fl_str_mv |
Univ Sao Paulo, Conjunto Quimicas |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128766992449536 |