Investigação dos efeitos tóxicos, citotóxicos, genotóxicos e mutagênicos do inseticida Curbix® 200SC (ethiprole) em organismos não alvos

• Autor(a) principal: Guedes, Thays de Andrade [UNESP]
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/134121
• topic: Insecticides; Inseticidas - Toxicologia; Plantas - Efeito dos inseticidas; Inseticidas - Efeito fisiologico; Cebola; Tilápia-do-Nilo; Toxicidade - Testes

Pesticides represent a large proportion of the compounds synthesized by the chemical industry for domestic and agriculture use. The oldest families are being progressively replaced by new families of insecticides due to increased resistance to the old pesticides and their delicate implication for public health. In recent years, fipronil is no longer one of the best alternatives among the insecticides and happened to be in the crosshairs of government agencies and the scientific community for progressive global suppression because of its deleterious effects on the environment. Comparative studies on the efficiency of a new member of the phenylpyrazole family show that the ethiprole is basically as effective as analog fipronil, even with its lower lipophilicity and lower toxicity. This compound has been widely used in crops like cane sugar and rice and marketed as a foliar and soil insecticide and the use of seed treatment. However, little is known about the action of ethiprole on non-target organisms and the light incidence influence their action. This study aimed to investigate the potential toxic, cytotoxic and genotoxic of Curbix®, commercial product ethiprole. The evaluations were made by chromosome aberration test (CA) and micronuclei (MN) in Allium cepa (onion) and the MN test and comet assay in Oreochromis niloticus (Nile tilapia). The A. cepa tests indicated genotoxicity for all ethiprole concentrations and cytotoxicity at all concentrations exposed to light. The most induction of nuclear buds suggested aneugenic action for the insecticide. The O. niloticus tests pointed pesticide genotoxicity only for the lowest concentration tested, it shows lower sensitivity of these organisms than the onion