Intoxicação por metronidazol em cão - relato de caso

Detalhes bibliográficos
Autor(a) principal: Thomas Heckler, Marta Cristina [UNESP]
Data de Publicação: 2012
Outros Autores: Costa, Ciniro [UNESP], Costa, Hugo Riani [UNESP], Amorim, Rogerio Martins [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5433/1679-0359.2012v33n4p1531
http://hdl.handle.net/11449/13796
Resumo: Metronidazole is a nitronidazolic antibiotic used in veterinary medicine to the treatment of a variety of diseases. The cause of metronidazole neurotoxicity has not been determined. We report the case of a dog, female, Teckel, five-year-old, with a history of dorsiflexion of the tail, ataxia, muscle stiffness, recumbency, vertical nystagmus, apathy and anorexia, which was being medicated for seven days with metronidazole in a dose higher than the maximum recommended, and the neurological signs began after this period. Neurological signs were consistent with central vestibular dysfunction caused by metronidazole, such as ataxia and vertical nystagmus. In addition to the neurological changes, the clinical signs of anorexia and apathy are consistent with the administration of excessive doses of the medicine. The diagnosis of metronidazole-induced toxicosis is based on the history of normal to increased doses, clinical signs and resolution after discontinuation of the drug. In general, the prognosis is good after drug withdrawal and early diagnosis. Some dogs may die and others may recover completely. The neurotoxicosis has disappeared after the suspension of the medicine and supportive treatment. Veterinarians must be aware of potential complications associated with the use of this medicine, as well as limit their chronic use or high doses for the most severe cases, and diagnose the problem as quickly as possible to institute an early treatment.
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spelling Intoxicação por metronidazol em cão - relato de casoMetronidazole-induced toxicosis in dog - case reportDogsneurologynervous systemdrug toxicityMetronidazole is a nitronidazolic antibiotic used in veterinary medicine to the treatment of a variety of diseases. The cause of metronidazole neurotoxicity has not been determined. We report the case of a dog, female, Teckel, five-year-old, with a history of dorsiflexion of the tail, ataxia, muscle stiffness, recumbency, vertical nystagmus, apathy and anorexia, which was being medicated for seven days with metronidazole in a dose higher than the maximum recommended, and the neurological signs began after this period. Neurological signs were consistent with central vestibular dysfunction caused by metronidazole, such as ataxia and vertical nystagmus. In addition to the neurological changes, the clinical signs of anorexia and apathy are consistent with the administration of excessive doses of the medicine. The diagnosis of metronidazole-induced toxicosis is based on the history of normal to increased doses, clinical signs and resolution after discontinuation of the drug. In general, the prognosis is good after drug withdrawal and early diagnosis. Some dogs may die and others may recover completely. The neurotoxicosis has disappeared after the suspension of the medicine and supportive treatment. Veterinarians must be aware of potential complications associated with the use of this medicine, as well as limit their chronic use or high doses for the most severe cases, and diagnose the problem as quickly as possible to institute an early treatment.Univ Estadual Paulista, Fac Med Vet & Zootecnia, UNESP, Botucatu, SP, BrazilUNESP, Botucatu, SP, BrazilUNESP, Fac Med Vet & Zootecnia, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, UNESP, Botucatu, SP, BrazilUNESP, Botucatu, SP, BrazilUNESP, Fac Med Vet & Zootecnia, Botucatu, SP, BrazilUniversidade Estadual de Londrina (UEL)Universidade Estadual Paulista (Unesp)Thomas Heckler, Marta Cristina [UNESP]Costa, Ciniro [UNESP]Costa, Hugo Riani [UNESP]Amorim, Rogerio Martins [UNESP]2014-05-20T13:39:45Z2014-05-20T13:39:45Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1531-1538application/pdfhttp://dx.doi.org/10.5433/1679-0359.2012v33n4p1531Semina-ciencias Agrarias. Londrina: Universidade Estadual de Londrina (UEL), v. 33, n. 4, p. 1531-1538, 2012.1676-546Xhttp://hdl.handle.net/11449/1379610.5433/1679-0359.2012v33n4p1531WOS:000314513600033WOS000314513600033.pdf979099821263556392597694918070200000-0003-1854-2927Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporSemina: Ciências Agrárias0.349info:eu-repo/semantics/openAccess2023-10-26T06:07:55Zoai:repositorio.unesp.br:11449/13796Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:01:57.647860Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Intoxicação por metronidazol em cão - relato de caso
Metronidazole-induced toxicosis in dog - case report
title Intoxicação por metronidazol em cão - relato de caso
spellingShingle Intoxicação por metronidazol em cão - relato de caso
Thomas Heckler, Marta Cristina [UNESP]
Dogs
neurology
nervous system
drug toxicity
title_short Intoxicação por metronidazol em cão - relato de caso
title_full Intoxicação por metronidazol em cão - relato de caso
title_fullStr Intoxicação por metronidazol em cão - relato de caso
title_full_unstemmed Intoxicação por metronidazol em cão - relato de caso
title_sort Intoxicação por metronidazol em cão - relato de caso
author Thomas Heckler, Marta Cristina [UNESP]
author_facet Thomas Heckler, Marta Cristina [UNESP]
Costa, Ciniro [UNESP]
Costa, Hugo Riani [UNESP]
Amorim, Rogerio Martins [UNESP]
author_role author
author2 Costa, Ciniro [UNESP]
Costa, Hugo Riani [UNESP]
Amorim, Rogerio Martins [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Thomas Heckler, Marta Cristina [UNESP]
Costa, Ciniro [UNESP]
Costa, Hugo Riani [UNESP]
Amorim, Rogerio Martins [UNESP]
dc.subject.por.fl_str_mv Dogs
neurology
nervous system
drug toxicity
topic Dogs
neurology
nervous system
drug toxicity
description Metronidazole is a nitronidazolic antibiotic used in veterinary medicine to the treatment of a variety of diseases. The cause of metronidazole neurotoxicity has not been determined. We report the case of a dog, female, Teckel, five-year-old, with a history of dorsiflexion of the tail, ataxia, muscle stiffness, recumbency, vertical nystagmus, apathy and anorexia, which was being medicated for seven days with metronidazole in a dose higher than the maximum recommended, and the neurological signs began after this period. Neurological signs were consistent with central vestibular dysfunction caused by metronidazole, such as ataxia and vertical nystagmus. In addition to the neurological changes, the clinical signs of anorexia and apathy are consistent with the administration of excessive doses of the medicine. The diagnosis of metronidazole-induced toxicosis is based on the history of normal to increased doses, clinical signs and resolution after discontinuation of the drug. In general, the prognosis is good after drug withdrawal and early diagnosis. Some dogs may die and others may recover completely. The neurotoxicosis has disappeared after the suspension of the medicine and supportive treatment. Veterinarians must be aware of potential complications associated with the use of this medicine, as well as limit their chronic use or high doses for the most severe cases, and diagnose the problem as quickly as possible to institute an early treatment.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
2014-05-20T13:39:45Z
2014-05-20T13:39:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5433/1679-0359.2012v33n4p1531
Semina-ciencias Agrarias. Londrina: Universidade Estadual de Londrina (UEL), v. 33, n. 4, p. 1531-1538, 2012.
1676-546X
http://hdl.handle.net/11449/13796
10.5433/1679-0359.2012v33n4p1531
WOS:000314513600033
WOS000314513600033.pdf
9790998212635563
9259769491807020
0000-0003-1854-2927
url http://dx.doi.org/10.5433/1679-0359.2012v33n4p1531
http://hdl.handle.net/11449/13796
identifier_str_mv Semina-ciencias Agrarias. Londrina: Universidade Estadual de Londrina (UEL), v. 33, n. 4, p. 1531-1538, 2012.
1676-546X
10.5433/1679-0359.2012v33n4p1531
WOS:000314513600033
WOS000314513600033.pdf
9790998212635563
9259769491807020
0000-0003-1854-2927
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Semina: Ciências Agrárias
0.349
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1531-1538
application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual de Londrina (UEL)
publisher.none.fl_str_mv Universidade Estadual de Londrina (UEL)
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
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institution UNESP
reponame_str Repositório Institucional da UNESP
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