The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water

Detalhes bibliográficos
Autor(a) principal: Feitosa, Eloi [UNESP]
Data de Publicação: 2023
Outros Autores: Adati, Renata D., Karlsson, Göran
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.tca.2023.179498
http://hdl.handle.net/11449/247101
Resumo: Cationic dioctadecyldimethylammonium bromide and chloride (DODAB and DODAC) lipids assemble in water as unilamellar vesicles or more complex bilayer structures depending on the lipid concentration, counter-ion, solvent characteristics, etc. By using differential scanning calorimetry (DSC) and cryogenic transmission electron microscopy (cryo-TEM) techniques we investigated the structural and thermal properties of these two widely investigated molecules at 1–20 mM in water. Changes in the DSC thermogram profile indicate that DODAB bilayers undergo more structural changes than DODAC, while Cryo-TEM micrographs show that, in this range of concentration, DODAB assembles as more complex bilayer structures than DODAC, which assemble predominantly as unilamellar vesicles. These findings thus indicate that DODAC is preferable to DODAB at 1–20 mM for the preparation of unilamellar vesicles.
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spelling The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in waterCationic vesiclesCryo-TEMDifferential scanning calorimetryDODABDODACThermal behaviorCationic dioctadecyldimethylammonium bromide and chloride (DODAB and DODAC) lipids assemble in water as unilamellar vesicles or more complex bilayer structures depending on the lipid concentration, counter-ion, solvent characteristics, etc. By using differential scanning calorimetry (DSC) and cryogenic transmission electron microscopy (cryo-TEM) techniques we investigated the structural and thermal properties of these two widely investigated molecules at 1–20 mM in water. Changes in the DSC thermogram profile indicate that DODAB bilayers undergo more structural changes than DODAC, while Cryo-TEM micrographs show that, in this range of concentration, DODAB assembles as more complex bilayer structures than DODAC, which assemble predominantly as unilamellar vesicles. These findings thus indicate that DODAC is preferable to DODAB at 1–20 mM for the preparation of unilamellar vesicles.Universidade Estadual PaulistaUppsala UniversitetDepartment of Physics São Paulo State University, Rua Cristóvão Colombo, 2265, SPAcademic Department of Chemistry and Biology Federal Technological University of Paraná (UTFPR)Department of Physical and Analytical Chemistry (BMC) Uppsala University, P. O. Box 579, UppsalaDepartment of Physics São Paulo State University, Rua Cristóvão Colombo, 2265, SPUppsala Universitet: 309346/2019–3Universidade Estadual Paulista (UNESP)Federal Technological University of Paraná (UTFPR)Uppsala UniversityFeitosa, Eloi [UNESP]Adati, Renata D.Karlsson, Göran2023-07-29T13:06:18Z2023-07-29T13:06:18Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tca.2023.179498Thermochimica Acta, v. 724.0040-6031http://hdl.handle.net/11449/24710110.1016/j.tca.2023.1794982-s2.0-85151438785Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengThermochimica Actainfo:eu-repo/semantics/openAccess2023-07-29T13:06:18Zoai:repositorio.unesp.br:11449/247101Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:10:50.995508Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water
title The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water
spellingShingle The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water
Feitosa, Eloi [UNESP]
Cationic vesicles
Cryo-TEM
Differential scanning calorimetry
DODAB
DODAC
Thermal behavior
title_short The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water
title_full The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water
title_fullStr The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water
title_full_unstemmed The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water
title_sort The role of counterion and concentration on the thermal behavior and structure of dioctadecyldimethylammonium bromide and chloride in water
author Feitosa, Eloi [UNESP]
author_facet Feitosa, Eloi [UNESP]
Adati, Renata D.
Karlsson, Göran
author_role author
author2 Adati, Renata D.
Karlsson, Göran
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Federal Technological University of Paraná (UTFPR)
Uppsala University
dc.contributor.author.fl_str_mv Feitosa, Eloi [UNESP]
Adati, Renata D.
Karlsson, Göran
dc.subject.por.fl_str_mv Cationic vesicles
Cryo-TEM
Differential scanning calorimetry
DODAB
DODAC
Thermal behavior
topic Cationic vesicles
Cryo-TEM
Differential scanning calorimetry
DODAB
DODAC
Thermal behavior
description Cationic dioctadecyldimethylammonium bromide and chloride (DODAB and DODAC) lipids assemble in water as unilamellar vesicles or more complex bilayer structures depending on the lipid concentration, counter-ion, solvent characteristics, etc. By using differential scanning calorimetry (DSC) and cryogenic transmission electron microscopy (cryo-TEM) techniques we investigated the structural and thermal properties of these two widely investigated molecules at 1–20 mM in water. Changes in the DSC thermogram profile indicate that DODAB bilayers undergo more structural changes than DODAC, while Cryo-TEM micrographs show that, in this range of concentration, DODAB assembles as more complex bilayer structures than DODAC, which assemble predominantly as unilamellar vesicles. These findings thus indicate that DODAC is preferable to DODAB at 1–20 mM for the preparation of unilamellar vesicles.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T13:06:18Z
2023-07-29T13:06:18Z
2023-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.tca.2023.179498
Thermochimica Acta, v. 724.
0040-6031
http://hdl.handle.net/11449/247101
10.1016/j.tca.2023.179498
2-s2.0-85151438785
url http://dx.doi.org/10.1016/j.tca.2023.179498
http://hdl.handle.net/11449/247101
identifier_str_mv Thermochimica Acta, v. 724.
0040-6031
10.1016/j.tca.2023.179498
2-s2.0-85151438785
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Thermochimica Acta
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128766990352384

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