Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice

Detalhes bibliográficos
Autor(a) principal: Gouveia, M. C.P. [UNESP]
Data de Publicação: 2021
Outros Autores: Minto, B. W. [UNESP], Sargi, L. F. [UNESP], Souza, R. L., Pazzini, J. M., Colodel, E. M., Silva, V. C.P., Cassino, P. C. [UNESP], Dias, L. G.G.G. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-4162-12289
http://hdl.handle.net/11449/223215
Resumo: The aim of this study was to evaluate the topical application of alcoholic extracts of Dipteryx alata Vogel almonds and bark in skin wound healing in mice. Fifty-four C57BL/6 mice were equally distributed into three groups: Control, Almond, and Bark. A 9 mm skin fragment was resected from the dorsal region of the animals’ thorax. The wounds were submitted to topical application of base cream (vehicle), 10% hydroalcoholic almond extract, or bark extract twice a day. Macroscopic, histological, and immunohistochemical evaluations were conducted on the 7th, 14th, and 21st postoperative days. No significant difference was observed regarding skin wound area among groups, with the parameter presenting only a temporal effect on healing (p>0.05). The almond and control groups exhibited more intense collagenization than the bark group (p<0.05). Dipteryx alata Vogel showed to be inert in the wound healing process in mice
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spelling Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 miceAvaliação do extrato alcoólico da casca e da semente da Dipteryx alata Vogel na cicatrização da pele de camundongos C57BL/6BaruEpithelializationLeguminosaePhytotherapicSkin woundsThe aim of this study was to evaluate the topical application of alcoholic extracts of Dipteryx alata Vogel almonds and bark in skin wound healing in mice. Fifty-four C57BL/6 mice were equally distributed into three groups: Control, Almond, and Bark. A 9 mm skin fragment was resected from the dorsal region of the animals’ thorax. The wounds were submitted to topical application of base cream (vehicle), 10% hydroalcoholic almond extract, or bark extract twice a day. Macroscopic, histological, and immunohistochemical evaluations were conducted on the 7th, 14th, and 21st postoperative days. No significant difference was observed regarding skin wound area among groups, with the parameter presenting only a temporal effect on healing (p>0.05). The almond and control groups exhibited more intense collagenization than the bark group (p<0.05). Dipteryx alata Vogel showed to be inert in the wound healing process in miceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinária, SPUniversidade Federal de Mato Grosso, MTUnião das Faculdades dos Grandes Lagos, SPUniversidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinária, SPFAPESP: 2018/25061-6Universidade Estadual Paulista (UNESP)Universidade Federal de Mato GrossoUnião das Faculdades dos Grandes LagosGouveia, M. C.P. [UNESP]Minto, B. W. [UNESP]Sargi, L. F. [UNESP]Souza, R. L.Pazzini, J. M.Colodel, E. M.Silva, V. C.P.Cassino, P. C. [UNESP]Dias, L. G.G.G. [UNESP]2022-04-28T19:49:24Z2022-04-28T19:49:24Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1315-1322http://dx.doi.org/10.1590/1678-4162-12289Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 73, n. 6, p. 1315-1322, 2021.1678-41620102-0935http://hdl.handle.net/11449/22321510.1590/1678-4162-122892-s2.0-85122588219Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro de Medicina Veterinaria e Zootecniainfo:eu-repo/semantics/openAccess2022-04-28T19:49:24Zoai:repositorio.unesp.br:11449/223215Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:53:21.422326Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
Avaliação do extrato alcoólico da casca e da semente da Dipteryx alata Vogel na cicatrização da pele de camundongos C57BL/6
title Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
spellingShingle Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
Gouveia, M. C.P. [UNESP]
Baru
Epithelialization
Leguminosae
Phytotherapic
Skin wounds
title_short Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
title_full Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
title_fullStr Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
title_full_unstemmed Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
title_sort Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice
author Gouveia, M. C.P. [UNESP]
author_facet Gouveia, M. C.P. [UNESP]
Minto, B. W. [UNESP]
Sargi, L. F. [UNESP]
Souza, R. L.
Pazzini, J. M.
Colodel, E. M.
Silva, V. C.P.
Cassino, P. C. [UNESP]
Dias, L. G.G.G. [UNESP]
author_role author
author2 Minto, B. W. [UNESP]
Sargi, L. F. [UNESP]
Souza, R. L.
Pazzini, J. M.
Colodel, E. M.
Silva, V. C.P.
Cassino, P. C. [UNESP]
Dias, L. G.G.G. [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade Federal de Mato Grosso
União das Faculdades dos Grandes Lagos
dc.contributor.author.fl_str_mv Gouveia, M. C.P. [UNESP]
Minto, B. W. [UNESP]
Sargi, L. F. [UNESP]
Souza, R. L.
Pazzini, J. M.
Colodel, E. M.
Silva, V. C.P.
Cassino, P. C. [UNESP]
Dias, L. G.G.G. [UNESP]
dc.subject.por.fl_str_mv Baru
Epithelialization
Leguminosae
Phytotherapic
Skin wounds
topic Baru
Epithelialization
Leguminosae
Phytotherapic
Skin wounds
description The aim of this study was to evaluate the topical application of alcoholic extracts of Dipteryx alata Vogel almonds and bark in skin wound healing in mice. Fifty-four C57BL/6 mice were equally distributed into three groups: Control, Almond, and Bark. A 9 mm skin fragment was resected from the dorsal region of the animals’ thorax. The wounds were submitted to topical application of base cream (vehicle), 10% hydroalcoholic almond extract, or bark extract twice a day. Macroscopic, histological, and immunohistochemical evaluations were conducted on the 7th, 14th, and 21st postoperative days. No significant difference was observed regarding skin wound area among groups, with the parameter presenting only a temporal effect on healing (p>0.05). The almond and control groups exhibited more intense collagenization than the bark group (p<0.05). Dipteryx alata Vogel showed to be inert in the wound healing process in mice
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
2022-04-28T19:49:24Z
2022-04-28T19:49:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-4162-12289
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 73, n. 6, p. 1315-1322, 2021.
1678-4162
0102-0935
http://hdl.handle.net/11449/223215
10.1590/1678-4162-12289
2-s2.0-85122588219
url http://dx.doi.org/10.1590/1678-4162-12289
http://hdl.handle.net/11449/223215
identifier_str_mv Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 73, n. 6, p. 1315-1322, 2021.
1678-4162
0102-0935
10.1590/1678-4162-12289
2-s2.0-85122588219
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinaria e Zootecnia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1315-1322
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129561705054208

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