Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente

Detalhes bibliográficos
Autor(a) principal: Toni, Maria Carolina [UNESP]
Data de Publicação: 2014
Tipo de documento: Tese
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/122101
Resumo: Colic syndrome is one of the most important problems of equine health, considering that damage to the intestinal barrier can lead to systemic inflammatory response syndrome, which can progress to sepsis. A significant consequence of sepsis is myocardial dysfunction. The aim of this study was to noninvasively evaluate the effects of endotoxemia and hence of sepsis related to colic syndrome using conventional two-dimensional echocardiography and tissue Doppler echocardiography on left ventricular indices, namely systolic and diastolic functions, in horses subjected to obstruction of the descending colon. The study was conducted at Governador Laudo Natel Veterinary Teaching Hospital - Faculdade de Ciências Agrárias e Veterinárias – Unesp – Jaboticabal, and was developed in parallel with a study that assessed inflammatory responses in horses after experimental obstruction of the descending colon. A single group was formed including eight adult mongrel horses with four females and four males, with average weight of 3705 kg and age of 101 years, were selected. The horses underwent laparotomy for obstruction of the descending colon by introducing a compression balloon. Echocardiographic variables were recorded in two stages, M0 representing baseline conventional and Tissue Doppler echocardiographic variables, and M48h representing the same parameters assessed 48 hours after intraluminal obstruction of the descending colon. Venous blood samples were collected for analysis and measurement of serum cytokine concentrations. Serum analysis revealed increased fibrinogen concentration and reduced platelet count. Doppler echocardiography showed decreased levels of VTi in M48h. Tissue Doppler allowed for determination of the occurrence of impaired systolic function indicated by the reduction of Sm in M48h. The change in the values of the ratio Em/Am as well as the increase of IVRT in M48h indicated impairment of diastolic function ...
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spelling Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendenteEquinoDoppler, EcocardiografiaIntestino grossoColon (Anatomia)Intestinos - ObstruçõesIntestinesColic syndrome is one of the most important problems of equine health, considering that damage to the intestinal barrier can lead to systemic inflammatory response syndrome, which can progress to sepsis. A significant consequence of sepsis is myocardial dysfunction. The aim of this study was to noninvasively evaluate the effects of endotoxemia and hence of sepsis related to colic syndrome using conventional two-dimensional echocardiography and tissue Doppler echocardiography on left ventricular indices, namely systolic and diastolic functions, in horses subjected to obstruction of the descending colon. The study was conducted at Governador Laudo Natel Veterinary Teaching Hospital - Faculdade de Ciências Agrárias e Veterinárias – Unesp – Jaboticabal, and was developed in parallel with a study that assessed inflammatory responses in horses after experimental obstruction of the descending colon. A single group was formed including eight adult mongrel horses with four females and four males, with average weight of 3705 kg and age of 101 years, were selected. The horses underwent laparotomy for obstruction of the descending colon by introducing a compression balloon. Echocardiographic variables were recorded in two stages, M0 representing baseline conventional and Tissue Doppler echocardiographic variables, and M48h representing the same parameters assessed 48 hours after intraluminal obstruction of the descending colon. Venous blood samples were collected for analysis and measurement of serum cytokine concentrations. Serum analysis revealed increased fibrinogen concentration and reduced platelet count. Doppler echocardiography showed decreased levels of VTi in M48h. Tissue Doppler allowed for determination of the occurrence of impaired systolic function indicated by the reduction of Sm in M48h. The change in the values of the ratio Em/Am as well as the increase of IVRT in M48h indicated impairment of diastolic function ...A síndrome cólica é um dos mais importantes problemas de saúde equina, uma vez que a barreira intestinal danificada estimula a ocorrência da síndrome da resposta inflamatória sistêmica que pode evoluir para sepse. Uma consequência significativa da sepse é a disfunção miocárdica. O objetivo do presente estudo foi avaliar de forma não invasiva os efeitos da endotoxemia e, consequentemente, da sepse, relacionadas à síndrome cólica sobre os índices ventriculares esquerdos, a função sistólica e diastólica do miocárdio, com o uso da ecocardiografia bidimensional convencional e da ecoDopplercardiografia tecidual em equinos submetidos à obstrução do colón descendente. O estudo foi realizado no Hospital Veterinário “Governador Laudo Natel”, da Faculdade de Ciências Agrárias e Veterinárias – Unesp – Câmpus de Jaboticabal e foi desenvolvido paralelamente a um estudo realizado para avaliar respostas inflamatórias em equinos após obstrução experimental do cólon descendente. Foram alocados em um único grupo, oito equinos adultos, sendo quatro machos e quatro fêmeas, sem raça definida, com peso médio de 3705 Kg e idade média de 101 anos. Os equinos foram submetidos a laparotomia mediana para obstrução do cólon descendente por meio de introdução de um balão compressor. As variáveis ecocardiográficas foram analisadas em dois momentos, M0 que representa as variáveis ecocardiográficas convencionais e teciduais basais e M48h que representa os mesmos parâmetros avaliados 48 horas após a obstrução intraluminal do colón descendente. Amostras de sangue venoso foram coletadas para análise sérica e dosagem de concentração de citocinas. Na análise sérica foram observados elevações na concentração de fibrinogênio e redução nos níveis plaquetários. Ao exame ecoDopplercardiográfico, observou-se redução dos valores de VTi no M48h. Com o uso do Doppler tecidual, foi possível ...Universidade Estadual Paulista (Unesp)Canola, Júlio Carlos [UNESP]Universidade Estadual Paulista (Unesp)Toni, Maria Carolina [UNESP]2015-04-09T12:28:21Z2015-04-09T12:28:21Z2014-12-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisvii, 46 p. : il.application/pdfTONI, Maria Carolina. Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente. 2014. vii, 46 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2014.http://hdl.handle.net/11449/122101000815219000815219.pdf33004102069P83144173608741010Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2024-06-05T18:01:18Zoai:repositorio.unesp.br:11449/122101Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:45:14.670129Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
title Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
spellingShingle Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
Toni, Maria Carolina [UNESP]
Equino
Doppler, Ecocardiografia
Intestino grosso
Colon (Anatomia)
Intestinos - Obstruções
Intestines
title_short Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
title_full Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
title_fullStr Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
title_full_unstemmed Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
title_sort Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
author Toni, Maria Carolina [UNESP]
author_facet Toni, Maria Carolina [UNESP]
author_role author
dc.contributor.none.fl_str_mv Canola, Júlio Carlos [UNESP]
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Toni, Maria Carolina [UNESP]
dc.subject.por.fl_str_mv Equino
Doppler, Ecocardiografia
Intestino grosso
Colon (Anatomia)
Intestinos - Obstruções
Intestines
topic Equino
Doppler, Ecocardiografia
Intestino grosso
Colon (Anatomia)
Intestinos - Obstruções
Intestines
description Colic syndrome is one of the most important problems of equine health, considering that damage to the intestinal barrier can lead to systemic inflammatory response syndrome, which can progress to sepsis. A significant consequence of sepsis is myocardial dysfunction. The aim of this study was to noninvasively evaluate the effects of endotoxemia and hence of sepsis related to colic syndrome using conventional two-dimensional echocardiography and tissue Doppler echocardiography on left ventricular indices, namely systolic and diastolic functions, in horses subjected to obstruction of the descending colon. The study was conducted at Governador Laudo Natel Veterinary Teaching Hospital - Faculdade de Ciências Agrárias e Veterinárias – Unesp – Jaboticabal, and was developed in parallel with a study that assessed inflammatory responses in horses after experimental obstruction of the descending colon. A single group was formed including eight adult mongrel horses with four females and four males, with average weight of 3705 kg and age of 101 years, were selected. The horses underwent laparotomy for obstruction of the descending colon by introducing a compression balloon. Echocardiographic variables were recorded in two stages, M0 representing baseline conventional and Tissue Doppler echocardiographic variables, and M48h representing the same parameters assessed 48 hours after intraluminal obstruction of the descending colon. Venous blood samples were collected for analysis and measurement of serum cytokine concentrations. Serum analysis revealed increased fibrinogen concentration and reduced platelet count. Doppler echocardiography showed decreased levels of VTi in M48h. Tissue Doppler allowed for determination of the occurrence of impaired systolic function indicated by the reduction of Sm in M48h. The change in the values of the ratio Em/Am as well as the increase of IVRT in M48h indicated impairment of diastolic function ...
publishDate 2014
dc.date.none.fl_str_mv 2014-12-02
2015-04-09T12:28:21Z
2015-04-09T12:28:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv TONI, Maria Carolina. Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente. 2014. vii, 46 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2014.
http://hdl.handle.net/11449/122101
000815219
000815219.pdf
33004102069P8
3144173608741010
identifier_str_mv TONI, Maria Carolina. Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente. 2014. vii, 46 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2014.
000815219
000815219.pdf
33004102069P8
3144173608741010
url http://hdl.handle.net/11449/122101
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv vii, 46 p. : il.
application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.source.none.fl_str_mv Aleph
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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