Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/122101 |
Resumo: | Colic syndrome is one of the most important problems of equine health, considering that damage to the intestinal barrier can lead to systemic inflammatory response syndrome, which can progress to sepsis. A significant consequence of sepsis is myocardial dysfunction. The aim of this study was to noninvasively evaluate the effects of endotoxemia and hence of sepsis related to colic syndrome using conventional two-dimensional echocardiography and tissue Doppler echocardiography on left ventricular indices, namely systolic and diastolic functions, in horses subjected to obstruction of the descending colon. The study was conducted at Governador Laudo Natel Veterinary Teaching Hospital - Faculdade de Ciências Agrárias e Veterinárias – Unesp – Jaboticabal, and was developed in parallel with a study that assessed inflammatory responses in horses after experimental obstruction of the descending colon. A single group was formed including eight adult mongrel horses with four females and four males, with average weight of 3705 kg and age of 101 years, were selected. The horses underwent laparotomy for obstruction of the descending colon by introducing a compression balloon. Echocardiographic variables were recorded in two stages, M0 representing baseline conventional and Tissue Doppler echocardiographic variables, and M48h representing the same parameters assessed 48 hours after intraluminal obstruction of the descending colon. Venous blood samples were collected for analysis and measurement of serum cytokine concentrations. Serum analysis revealed increased fibrinogen concentration and reduced platelet count. Doppler echocardiography showed decreased levels of VTi in M48h. Tissue Doppler allowed for determination of the occurrence of impaired systolic function indicated by the reduction of Sm in M48h. The change in the values of the ratio Em/Am as well as the increase of IVRT in M48h indicated impairment of diastolic function ... |
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Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendenteEquinoDoppler, EcocardiografiaIntestino grossoColon (Anatomia)Intestinos - ObstruçõesIntestinesColic syndrome is one of the most important problems of equine health, considering that damage to the intestinal barrier can lead to systemic inflammatory response syndrome, which can progress to sepsis. A significant consequence of sepsis is myocardial dysfunction. The aim of this study was to noninvasively evaluate the effects of endotoxemia and hence of sepsis related to colic syndrome using conventional two-dimensional echocardiography and tissue Doppler echocardiography on left ventricular indices, namely systolic and diastolic functions, in horses subjected to obstruction of the descending colon. The study was conducted at Governador Laudo Natel Veterinary Teaching Hospital - Faculdade de Ciências Agrárias e Veterinárias – Unesp – Jaboticabal, and was developed in parallel with a study that assessed inflammatory responses in horses after experimental obstruction of the descending colon. A single group was formed including eight adult mongrel horses with four females and four males, with average weight of 3705 kg and age of 101 years, were selected. The horses underwent laparotomy for obstruction of the descending colon by introducing a compression balloon. Echocardiographic variables were recorded in two stages, M0 representing baseline conventional and Tissue Doppler echocardiographic variables, and M48h representing the same parameters assessed 48 hours after intraluminal obstruction of the descending colon. Venous blood samples were collected for analysis and measurement of serum cytokine concentrations. Serum analysis revealed increased fibrinogen concentration and reduced platelet count. Doppler echocardiography showed decreased levels of VTi in M48h. Tissue Doppler allowed for determination of the occurrence of impaired systolic function indicated by the reduction of Sm in M48h. The change in the values of the ratio Em/Am as well as the increase of IVRT in M48h indicated impairment of diastolic function ...A síndrome cólica é um dos mais importantes problemas de saúde equina, uma vez que a barreira intestinal danificada estimula a ocorrência da síndrome da resposta inflamatória sistêmica que pode evoluir para sepse. Uma consequência significativa da sepse é a disfunção miocárdica. O objetivo do presente estudo foi avaliar de forma não invasiva os efeitos da endotoxemia e, consequentemente, da sepse, relacionadas à síndrome cólica sobre os índices ventriculares esquerdos, a função sistólica e diastólica do miocárdio, com o uso da ecocardiografia bidimensional convencional e da ecoDopplercardiografia tecidual em equinos submetidos à obstrução do colón descendente. O estudo foi realizado no Hospital Veterinário “Governador Laudo Natel”, da Faculdade de Ciências Agrárias e Veterinárias – Unesp – Câmpus de Jaboticabal e foi desenvolvido paralelamente a um estudo realizado para avaliar respostas inflamatórias em equinos após obstrução experimental do cólon descendente. Foram alocados em um único grupo, oito equinos adultos, sendo quatro machos e quatro fêmeas, sem raça definida, com peso médio de 3705 Kg e idade média de 101 anos. Os equinos foram submetidos a laparotomia mediana para obstrução do cólon descendente por meio de introdução de um balão compressor. As variáveis ecocardiográficas foram analisadas em dois momentos, M0 que representa as variáveis ecocardiográficas convencionais e teciduais basais e M48h que representa os mesmos parâmetros avaliados 48 horas após a obstrução intraluminal do colón descendente. Amostras de sangue venoso foram coletadas para análise sérica e dosagem de concentração de citocinas. Na análise sérica foram observados elevações na concentração de fibrinogênio e redução nos níveis plaquetários. Ao exame ecoDopplercardiográfico, observou-se redução dos valores de VTi no M48h. Com o uso do Doppler tecidual, foi possível ...Universidade Estadual Paulista (Unesp)Canola, Júlio Carlos [UNESP]Universidade Estadual Paulista (Unesp)Toni, Maria Carolina [UNESP]2015-04-09T12:28:21Z2015-04-09T12:28:21Z2014-12-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisvii, 46 p. : il.application/pdfTONI, Maria Carolina. Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente. 2014. vii, 46 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2014.http://hdl.handle.net/11449/122101000815219000815219.pdf33004102069P83144173608741010Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2024-06-05T18:01:18Zoai:repositorio.unesp.br:11449/122101Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:45:14.670129Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente |
title |
Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente |
spellingShingle |
Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente Toni, Maria Carolina [UNESP] Equino Doppler, Ecocardiografia Intestino grosso Colon (Anatomia) Intestinos - Obstruções Intestines |
title_short |
Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente |
title_full |
Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente |
title_fullStr |
Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente |
title_full_unstemmed |
Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente |
title_sort |
Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente |
author |
Toni, Maria Carolina [UNESP] |
author_facet |
Toni, Maria Carolina [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Canola, Júlio Carlos [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Toni, Maria Carolina [UNESP] |
dc.subject.por.fl_str_mv |
Equino Doppler, Ecocardiografia Intestino grosso Colon (Anatomia) Intestinos - Obstruções Intestines |
topic |
Equino Doppler, Ecocardiografia Intestino grosso Colon (Anatomia) Intestinos - Obstruções Intestines |
description |
Colic syndrome is one of the most important problems of equine health, considering that damage to the intestinal barrier can lead to systemic inflammatory response syndrome, which can progress to sepsis. A significant consequence of sepsis is myocardial dysfunction. The aim of this study was to noninvasively evaluate the effects of endotoxemia and hence of sepsis related to colic syndrome using conventional two-dimensional echocardiography and tissue Doppler echocardiography on left ventricular indices, namely systolic and diastolic functions, in horses subjected to obstruction of the descending colon. The study was conducted at Governador Laudo Natel Veterinary Teaching Hospital - Faculdade de Ciências Agrárias e Veterinárias – Unesp – Jaboticabal, and was developed in parallel with a study that assessed inflammatory responses in horses after experimental obstruction of the descending colon. A single group was formed including eight adult mongrel horses with four females and four males, with average weight of 3705 kg and age of 101 years, were selected. The horses underwent laparotomy for obstruction of the descending colon by introducing a compression balloon. Echocardiographic variables were recorded in two stages, M0 representing baseline conventional and Tissue Doppler echocardiographic variables, and M48h representing the same parameters assessed 48 hours after intraluminal obstruction of the descending colon. Venous blood samples were collected for analysis and measurement of serum cytokine concentrations. Serum analysis revealed increased fibrinogen concentration and reduced platelet count. Doppler echocardiography showed decreased levels of VTi in M48h. Tissue Doppler allowed for determination of the occurrence of impaired systolic function indicated by the reduction of Sm in M48h. The change in the values of the ratio Em/Am as well as the increase of IVRT in M48h indicated impairment of diastolic function ... |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-02 2015-04-09T12:28:21Z 2015-04-09T12:28:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
TONI, Maria Carolina. Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente. 2014. vii, 46 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2014. http://hdl.handle.net/11449/122101 000815219 000815219.pdf 33004102069P8 3144173608741010 |
identifier_str_mv |
TONI, Maria Carolina. Ecodopplercardiografia em equinos submetidos à obstrução de cólon descendente. 2014. vii, 46 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2014. 000815219 000815219.pdf 33004102069P8 3144173608741010 |
url |
http://hdl.handle.net/11449/122101 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
vii, 46 p. : il. application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
Aleph reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129242400030720 |