Suplementação de nitrito e exercício físico: efeito na pressão arterial e rigidez arterial de ratos treinados e não treinados

• Autor(a) principal: Souza, Thiago Pereira de [UNESP]
• Data de Publicação: 2018
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/203988; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2019-03-26/000913765.pdf
• topic: Oxido nítrico; Educação fisica; Hipertensão; Nitric oxide

Hypertension (AH) is considered a major public health problem and one of the main risk factors for the development of cardiovascular diseases. Physical exercise has been increasingly recommended as a form of HA treatment, since it promotes several cardiovascular benefits. Nitric oxide (NO) stands out as a humoral mechanism of blood pressure (BP) control, because it is a potent vasodilator. In this context, nitrite supplementation, an NO metabolite, can stimulate the Nitrate / Nitrite / NO pathway. However, nothing is known about the effects of its supplementation on sedentary and trained animals. Thus, the objective of this study was to verify the effect of nitrite supplementation on physical capacity, BP and arterial stiffness in trained and sedentary rats. 40 rats (Wistar) divided into: Sedentary Control (SC) and supplemented (SN), Trained Control (CT) and supplemented (TN). The animals were submitted to a treadmill exercise training protocol (TF) (60% of the maximum capacity, 1h/day, 5 times/week, 66 days) or maintained sedentary. In the last 6 days of the experimental protocol, they received supplementation with nitrite or water (15mg/kg, via gavage). Maximum physical capacity and pulse wave velocity (PWV) were assessed before and after the supplementation period, and caudal BP and plasma nitrite concentrations at the end of the experimental protocol. After the TF period and supplementation, the rats were euthanized by decapitation. Two-way ANOVA and Tukey post-hoc (p <0.05) were used for statistical analysis. TF was not effective in reducing PWV compared to the sedentary group (TC vs SC) and nitrite supplementation was not effective in decreasing PWV in the sedentary groups compared to control (SN vs SC)... (Complete abstract electronic acess below)