Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve

Detalhes bibliográficos
Autor(a) principal: Negrin, Ana Carolina
Data de Publicação: 2018
Outros Autores: de Jesus, Mariana Marcielo, Christante, Caroline Maria, da Silva, Danilo Grünig Humberto [UNESP], Taboga, Sebastião Roberto [UNESP], Pinto-Fochi, Maria Etelvina [UNESP], Góes, Rejane Maira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.reprotox.2018.08.011
http://hdl.handle.net/11449/180107
Resumo: This study evaluated the consequences of gestational exposure to di-n-butyl phthalate (DBP) for testicular steroidogenesis and sperm parameters of the adult gerbil and the interference of corn oil (co), a vehicle widely used for administration of liposoluble agents, on DBP effects. Pregnant gerbils received no treatment or were treated from gestational day 8 to 23 via gavage with 0.1 mL/day of co only or containing DBP (100 mg/kg/day). Maternal co intake enhanced serum estradiol levels and testicular content of ERα and reduced sperm reserve of adult offspring. Gestational DBP exposure caused dyslipidemia, increased serum and intratesticular estradiol levels and reduced sperm reserve and motility. Thus, maternal co supplementation alters circulating estradiol and impairs sperm quantity and quality of offspring. Gestational DBP exposure alters lipid metabolism and testicular steroidogenesis and worsens the negative effects of co on the sperm reserve and motility of gerbil. Therefore, co interferes with the reproductive response to DBP.
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spelling Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserveCorn oilDi-n-butyl phthalateLipid metabolismSperm motilitySperm reserveThis study evaluated the consequences of gestational exposure to di-n-butyl phthalate (DBP) for testicular steroidogenesis and sperm parameters of the adult gerbil and the interference of corn oil (co), a vehicle widely used for administration of liposoluble agents, on DBP effects. Pregnant gerbils received no treatment or were treated from gestational day 8 to 23 via gavage with 0.1 mL/day of co only or containing DBP (100 mg/kg/day). Maternal co intake enhanced serum estradiol levels and testicular content of ERα and reduced sperm reserve of adult offspring. Gestational DBP exposure caused dyslipidemia, increased serum and intratesticular estradiol levels and reduced sperm reserve and motility. Thus, maternal co supplementation alters circulating estradiol and impairs sperm quantity and quality of offspring. Gestational DBP exposure alters lipid metabolism and testicular steroidogenesis and worsens the negative effects of co on the sperm reserve and motility of gerbil. Therefore, co interferes with the reproductive response to DBP.Department of Functional and Structural Biology Institute of Biology University of Campinas – UNICAMPDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University – UNESPDepartment of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University – UNESPFaculdade de Medicina União das Faculdades dos Grandes Lagos – UNILAGODepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University – UNESPDepartment of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University – UNESPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)União das Faculdades dos Grandes Lagos – UNILAGONegrin, Ana Carolinade Jesus, Mariana MarcieloChristante, Caroline Mariada Silva, Danilo Grünig Humberto [UNESP]Taboga, Sebastião Roberto [UNESP]Pinto-Fochi, Maria Etelvina [UNESP]Góes, Rejane Maira [UNESP]2018-12-11T17:38:12Z2018-12-11T17:38:12Z2018-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article168-179application/pdfhttp://dx.doi.org/10.1016/j.reprotox.2018.08.011Reproductive Toxicology, v. 81, p. 168-179.1873-17080890-6238http://hdl.handle.net/11449/18010710.1016/j.reprotox.2018.08.0112-s2.0-850516752722-s2.0-85051675272.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproductive Toxicology0,846info:eu-repo/semantics/openAccess2023-12-03T06:16:42Zoai:repositorio.unesp.br:11449/180107Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:24:35.143067Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve
title Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve
spellingShingle Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve
Negrin, Ana Carolina
Corn oil
Di-n-butyl phthalate
Lipid metabolism
Sperm motility
Sperm reserve
title_short Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve
title_full Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve
title_fullStr Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve
title_full_unstemmed Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve
title_sort Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve
author Negrin, Ana Carolina
author_facet Negrin, Ana Carolina
de Jesus, Mariana Marcielo
Christante, Caroline Maria
da Silva, Danilo Grünig Humberto [UNESP]
Taboga, Sebastião Roberto [UNESP]
Pinto-Fochi, Maria Etelvina [UNESP]
Góes, Rejane Maira [UNESP]
author_role author
author2 de Jesus, Mariana Marcielo
Christante, Caroline Maria
da Silva, Danilo Grünig Humberto [UNESP]
Taboga, Sebastião Roberto [UNESP]
Pinto-Fochi, Maria Etelvina [UNESP]
Góes, Rejane Maira [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
União das Faculdades dos Grandes Lagos – UNILAGO
dc.contributor.author.fl_str_mv Negrin, Ana Carolina
de Jesus, Mariana Marcielo
Christante, Caroline Maria
da Silva, Danilo Grünig Humberto [UNESP]
Taboga, Sebastião Roberto [UNESP]
Pinto-Fochi, Maria Etelvina [UNESP]
Góes, Rejane Maira [UNESP]
dc.subject.por.fl_str_mv Corn oil
Di-n-butyl phthalate
Lipid metabolism
Sperm motility
Sperm reserve
topic Corn oil
Di-n-butyl phthalate
Lipid metabolism
Sperm motility
Sperm reserve
description This study evaluated the consequences of gestational exposure to di-n-butyl phthalate (DBP) for testicular steroidogenesis and sperm parameters of the adult gerbil and the interference of corn oil (co), a vehicle widely used for administration of liposoluble agents, on DBP effects. Pregnant gerbils received no treatment or were treated from gestational day 8 to 23 via gavage with 0.1 mL/day of co only or containing DBP (100 mg/kg/day). Maternal co intake enhanced serum estradiol levels and testicular content of ERα and reduced sperm reserve of adult offspring. Gestational DBP exposure caused dyslipidemia, increased serum and intratesticular estradiol levels and reduced sperm reserve and motility. Thus, maternal co supplementation alters circulating estradiol and impairs sperm quantity and quality of offspring. Gestational DBP exposure alters lipid metabolism and testicular steroidogenesis and worsens the negative effects of co on the sperm reserve and motility of gerbil. Therefore, co interferes with the reproductive response to DBP.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:38:12Z
2018-12-11T17:38:12Z
2018-10-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.reprotox.2018.08.011
Reproductive Toxicology, v. 81, p. 168-179.
1873-1708
0890-6238
http://hdl.handle.net/11449/180107
10.1016/j.reprotox.2018.08.011
2-s2.0-85051675272
2-s2.0-85051675272.pdf
url http://dx.doi.org/10.1016/j.reprotox.2018.08.011
http://hdl.handle.net/11449/180107
identifier_str_mv Reproductive Toxicology, v. 81, p. 168-179.
1873-1708
0890-6238
10.1016/j.reprotox.2018.08.011
2-s2.0-85051675272
2-s2.0-85051675272.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Reproductive Toxicology
0,846
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 168-179
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128230515802112

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