Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2012/750286 http://hdl.handle.net/11449/11472 |
Resumo: | The persistent inflammatory state is common in diabetes and chronic kidney disease (CKD). These patients present exercise intolerance and increased arterial stiffness. Long-term aerobic exercise has been associated with better arterial compliance, antidiabetic and antiinflammatory benefits. We assessed the hypothesis that in patients with diabetes and CKD, better aerobic capacity is associated with less inflammatory state and arterial stiffness. Thirty-nine CKD patients (17 in hemodialysis) were evaluated. According to CKD etiology two patient groups were obtained: group of diabetics (GD) was formed by 11 patients and nondiabetics (GND) formed by 28 patients. Central blood pressure and arterial stiffness were evaluated by Sphygmocor device. Carotida intima-media thickness (CA-IMT) was evaluated by ultrasonography. Aerobic capacity was measured by estimated VO(2)max according to treadmill test by Bruce protocol. The GD showed a higher frequency of C-reactive protein above laboratory cutoff (P = 0.044), higher frequency of male gender, and a non significant higher value of VO(2)max (P = 0.099). The CA-IMT was similar. Only better aerobic capacity was associated with lower frequency of high C-reactive protein when adjusted to diabetes and gender in a logistic regression model. In conclusion, aerobic capacity was associated with inflammatory state, in CKD patients, independently of diabetes presence. |
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Repositório Institucional da UNESP |
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Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic CapacityThe persistent inflammatory state is common in diabetes and chronic kidney disease (CKD). These patients present exercise intolerance and increased arterial stiffness. Long-term aerobic exercise has been associated with better arterial compliance, antidiabetic and antiinflammatory benefits. We assessed the hypothesis that in patients with diabetes and CKD, better aerobic capacity is associated with less inflammatory state and arterial stiffness. Thirty-nine CKD patients (17 in hemodialysis) were evaluated. According to CKD etiology two patient groups were obtained: group of diabetics (GD) was formed by 11 patients and nondiabetics (GND) formed by 28 patients. Central blood pressure and arterial stiffness were evaluated by Sphygmocor device. Carotida intima-media thickness (CA-IMT) was evaluated by ultrasonography. Aerobic capacity was measured by estimated VO(2)max according to treadmill test by Bruce protocol. The GD showed a higher frequency of C-reactive protein above laboratory cutoff (P = 0.044), higher frequency of male gender, and a non significant higher value of VO(2)max (P = 0.099). The CA-IMT was similar. Only better aerobic capacity was associated with lower frequency of high C-reactive protein when adjusted to diabetes and gender in a logistic regression model. In conclusion, aerobic capacity was associated with inflammatory state, in CKD patients, independently of diabetes presence.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)São Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Nephrol, BR-18618000 Botucatu, SP, BrazilSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Cardiol, BR-18618000 Botucatu, SP, BrazilSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Nephrol, BR-18618000 Botucatu, SP, BrazilSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Div Cardiol, BR-18618000 Botucatu, SP, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Shiraishi, Flavio Gobbis [UNESP]Belik, Fernanda Stringuetta [UNESP]Oliveira e Silva, Viviana Rugolo [UNESP]Martin, Luis Cuadrado [UNESP]Hueb, João Carlos [UNESP]Goncalves, Renato de Souza [UNESP]Caramori, Jacqueline Socorro Costa Teixeira [UNESP]Barretti, Pasqual [UNESP]Silva Franco, Roberto Jorge da [UNESP]2014-05-20T13:33:28Z2014-05-20T13:33:28Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://dx.doi.org/10.1155/2012/750286Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 6, 2012.1687-5214http://hdl.handle.net/11449/1147210.1155/2012/750286WOS:000303731000001WOS000303731000001.pdf5496411983893479709593355785515149232031684466150000-0003-4979-4836Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental Diabetes Researchinfo:eu-repo/semantics/openAccess2024-08-14T17:37:04Zoai:repositorio.unesp.br:11449/11472Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:37:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity |
title |
Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity |
spellingShingle |
Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity Shiraishi, Flavio Gobbis [UNESP] |
title_short |
Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity |
title_full |
Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity |
title_fullStr |
Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity |
title_full_unstemmed |
Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity |
title_sort |
Inflammation, Diabetes, and Chronic Kidney Disease: Role of Aerobic Capacity |
author |
Shiraishi, Flavio Gobbis [UNESP] |
author_facet |
Shiraishi, Flavio Gobbis [UNESP] Belik, Fernanda Stringuetta [UNESP] Oliveira e Silva, Viviana Rugolo [UNESP] Martin, Luis Cuadrado [UNESP] Hueb, João Carlos [UNESP] Goncalves, Renato de Souza [UNESP] Caramori, Jacqueline Socorro Costa Teixeira [UNESP] Barretti, Pasqual [UNESP] Silva Franco, Roberto Jorge da [UNESP] |
author_role |
author |
author2 |
Belik, Fernanda Stringuetta [UNESP] Oliveira e Silva, Viviana Rugolo [UNESP] Martin, Luis Cuadrado [UNESP] Hueb, João Carlos [UNESP] Goncalves, Renato de Souza [UNESP] Caramori, Jacqueline Socorro Costa Teixeira [UNESP] Barretti, Pasqual [UNESP] Silva Franco, Roberto Jorge da [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Shiraishi, Flavio Gobbis [UNESP] Belik, Fernanda Stringuetta [UNESP] Oliveira e Silva, Viviana Rugolo [UNESP] Martin, Luis Cuadrado [UNESP] Hueb, João Carlos [UNESP] Goncalves, Renato de Souza [UNESP] Caramori, Jacqueline Socorro Costa Teixeira [UNESP] Barretti, Pasqual [UNESP] Silva Franco, Roberto Jorge da [UNESP] |
description |
The persistent inflammatory state is common in diabetes and chronic kidney disease (CKD). These patients present exercise intolerance and increased arterial stiffness. Long-term aerobic exercise has been associated with better arterial compliance, antidiabetic and antiinflammatory benefits. We assessed the hypothesis that in patients with diabetes and CKD, better aerobic capacity is associated with less inflammatory state and arterial stiffness. Thirty-nine CKD patients (17 in hemodialysis) were evaluated. According to CKD etiology two patient groups were obtained: group of diabetics (GD) was formed by 11 patients and nondiabetics (GND) formed by 28 patients. Central blood pressure and arterial stiffness were evaluated by Sphygmocor device. Carotida intima-media thickness (CA-IMT) was evaluated by ultrasonography. Aerobic capacity was measured by estimated VO(2)max according to treadmill test by Bruce protocol. The GD showed a higher frequency of C-reactive protein above laboratory cutoff (P = 0.044), higher frequency of male gender, and a non significant higher value of VO(2)max (P = 0.099). The CA-IMT was similar. Only better aerobic capacity was associated with lower frequency of high C-reactive protein when adjusted to diabetes and gender in a logistic regression model. In conclusion, aerobic capacity was associated with inflammatory state, in CKD patients, independently of diabetes presence. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T13:33:28Z 2014-05-20T13:33:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2012/750286 Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 6, 2012. 1687-5214 http://hdl.handle.net/11449/11472 10.1155/2012/750286 WOS:000303731000001 WOS000303731000001.pdf 5496411983893479 7095933557855151 4923203168446615 0000-0003-4979-4836 |
url |
http://dx.doi.org/10.1155/2012/750286 http://hdl.handle.net/11449/11472 |
identifier_str_mv |
Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 6, 2012. 1687-5214 10.1155/2012/750286 WOS:000303731000001 WOS000303731000001.pdf 5496411983893479 7095933557855151 4923203168446615 0000-0003-4979-4836 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Experimental Diabetes Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128211390824448 |