Sitagliptin's effects on bone tissue and osseointegration in diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.archoralbio.2019.04.018 http://hdl.handle.net/11449/189098 |
Resumo: | Objective: To investigate the effects of sitagliptin, a dipeptidyl peptidase 4 inhibitor used to treat type II diabetes, on bone tissue and on implant osseointegration in diabetic rats. Design: Thirty-two male rats were divided into four groups: 1) Diabetic animals (GD); 2) Diabetic animals that received sitagliptin (GDS); 3) Normoglycemic animals (GN); and 4) Normoglycemic animals that received sitagliptin (GNS). All animals received titanium implants in the right tibia. Sitagliptin or water were administered for 4 weeks. Glycemia, HOMA-IR, insulinemia, microtomographic parameters of the left tibia and implant bone area fraction occupancy (BAFO) of the right tibia were evaluated. Results: The model used to induce diabetes led to hyperglycemia. However, HOMA-IR results showed no insulin resistance, and insulinemia was lower in diabetic animals, demonstrating the development of type I diabetes. Sitagliptin administration did not influence glycemic control. The diabetic animals showed a lower BAFO and bone volume fraction, as well as a lower trabecular number and thickness, revealing the deleterious effect of diabetes on bone metabolism and osseointegration. Conclusion: In this model, sitagliptin administration did not reverse the negative effects of type I diabetes on bone, suggesting that sitagliptin has no direct action on bone tissue and has no protective bone action in decompensated diabetic animals. |
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Sitagliptin's effects on bone tissue and osseointegration in diabetic ratsDipeptidyl peptidase 4ImplantsIncretinsObjective: To investigate the effects of sitagliptin, a dipeptidyl peptidase 4 inhibitor used to treat type II diabetes, on bone tissue and on implant osseointegration in diabetic rats. Design: Thirty-two male rats were divided into four groups: 1) Diabetic animals (GD); 2) Diabetic animals that received sitagliptin (GDS); 3) Normoglycemic animals (GN); and 4) Normoglycemic animals that received sitagliptin (GNS). All animals received titanium implants in the right tibia. Sitagliptin or water were administered for 4 weeks. Glycemia, HOMA-IR, insulinemia, microtomographic parameters of the left tibia and implant bone area fraction occupancy (BAFO) of the right tibia were evaluated. Results: The model used to induce diabetes led to hyperglycemia. However, HOMA-IR results showed no insulin resistance, and insulinemia was lower in diabetic animals, demonstrating the development of type I diabetes. Sitagliptin administration did not influence glycemic control. The diabetic animals showed a lower BAFO and bone volume fraction, as well as a lower trabecular number and thickness, revealing the deleterious effect of diabetes on bone metabolism and osseointegration. Conclusion: In this model, sitagliptin administration did not reverse the negative effects of type I diabetes on bone, suggesting that sitagliptin has no direct action on bone tissue and has no protective bone action in decompensated diabetic animals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Bioscience and Oral Diagnosis São Paulo State University (Unesp) Institute of Science and Technology, Av. Engenheiro Francisco José Longo, 777, São José dos CamposDepartment of Basic Science São Paulo State University (Unesp) School of Dentistry, Rua José Bonifácio, 1193, AraçatubaDepartment of Diagnosis and Surgery São Paulo State University (Unesp) Institute of Science and Technology, Av. Engenheiro Francisco José Longo, 777, São José dos CamposDepartment of Bioscience and Oral Diagnosis São Paulo State University (Unesp) Institute of Science and Technology, Av. Engenheiro Francisco José Longo, 777, São José dos CamposDepartment of Basic Science São Paulo State University (Unesp) School of Dentistry, Rua José Bonifácio, 1193, AraçatubaDepartment of Diagnosis and Surgery São Paulo State University (Unesp) Institute of Science and Technology, Av. Engenheiro Francisco José Longo, 777, São José dos CamposFAPESP: 2014/20973-6FAPESP: 2017/26461-5Universidade Estadual Paulista (Unesp)Bautista, Cristhian Reynaldo Gomez [UNESP]Santos, Ingrid Valadares dos [UNESP]Moraes, Renata Mendonça [UNESP]Chiba, Fernando Yamamoto [UNESP]Sumida, Doris Hissako [UNESP]de Moraes, Michele Bianchi [UNESP]de Vasconcellos, Luana Marotta Reis [UNESP]Anbinder, Ana Lia [UNESP]2019-10-06T16:29:43Z2019-10-06T16:29:43Z2019-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article238-243application/pdfhttp://dx.doi.org/10.1016/j.archoralbio.2019.04.018Archives of Oral Biology, v. 102, p. 238-243.1879-15060003-9969http://hdl.handle.net/11449/18909810.1016/j.archoralbio.2019.04.0182-s2.0-85065451721Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Oral Biologyinfo:eu-repo/semantics/openAccess2023-12-13T06:22:28Zoai:repositorio.unesp.br:11449/189098Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:14:51.506374Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sitagliptin's effects on bone tissue and osseointegration in diabetic rats |
title |
Sitagliptin's effects on bone tissue and osseointegration in diabetic rats |
spellingShingle |
Sitagliptin's effects on bone tissue and osseointegration in diabetic rats Bautista, Cristhian Reynaldo Gomez [UNESP] Dipeptidyl peptidase 4 Implants Incretins |
title_short |
Sitagliptin's effects on bone tissue and osseointegration in diabetic rats |
title_full |
Sitagliptin's effects on bone tissue and osseointegration in diabetic rats |
title_fullStr |
Sitagliptin's effects on bone tissue and osseointegration in diabetic rats |
title_full_unstemmed |
Sitagliptin's effects on bone tissue and osseointegration in diabetic rats |
title_sort |
Sitagliptin's effects on bone tissue and osseointegration in diabetic rats |
author |
Bautista, Cristhian Reynaldo Gomez [UNESP] |
author_facet |
Bautista, Cristhian Reynaldo Gomez [UNESP] Santos, Ingrid Valadares dos [UNESP] Moraes, Renata Mendonça [UNESP] Chiba, Fernando Yamamoto [UNESP] Sumida, Doris Hissako [UNESP] de Moraes, Michele Bianchi [UNESP] de Vasconcellos, Luana Marotta Reis [UNESP] Anbinder, Ana Lia [UNESP] |
author_role |
author |
author2 |
Santos, Ingrid Valadares dos [UNESP] Moraes, Renata Mendonça [UNESP] Chiba, Fernando Yamamoto [UNESP] Sumida, Doris Hissako [UNESP] de Moraes, Michele Bianchi [UNESP] de Vasconcellos, Luana Marotta Reis [UNESP] Anbinder, Ana Lia [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bautista, Cristhian Reynaldo Gomez [UNESP] Santos, Ingrid Valadares dos [UNESP] Moraes, Renata Mendonça [UNESP] Chiba, Fernando Yamamoto [UNESP] Sumida, Doris Hissako [UNESP] de Moraes, Michele Bianchi [UNESP] de Vasconcellos, Luana Marotta Reis [UNESP] Anbinder, Ana Lia [UNESP] |
dc.subject.por.fl_str_mv |
Dipeptidyl peptidase 4 Implants Incretins |
topic |
Dipeptidyl peptidase 4 Implants Incretins |
description |
Objective: To investigate the effects of sitagliptin, a dipeptidyl peptidase 4 inhibitor used to treat type II diabetes, on bone tissue and on implant osseointegration in diabetic rats. Design: Thirty-two male rats were divided into four groups: 1) Diabetic animals (GD); 2) Diabetic animals that received sitagliptin (GDS); 3) Normoglycemic animals (GN); and 4) Normoglycemic animals that received sitagliptin (GNS). All animals received titanium implants in the right tibia. Sitagliptin or water were administered for 4 weeks. Glycemia, HOMA-IR, insulinemia, microtomographic parameters of the left tibia and implant bone area fraction occupancy (BAFO) of the right tibia were evaluated. Results: The model used to induce diabetes led to hyperglycemia. However, HOMA-IR results showed no insulin resistance, and insulinemia was lower in diabetic animals, demonstrating the development of type I diabetes. Sitagliptin administration did not influence glycemic control. The diabetic animals showed a lower BAFO and bone volume fraction, as well as a lower trabecular number and thickness, revealing the deleterious effect of diabetes on bone metabolism and osseointegration. Conclusion: In this model, sitagliptin administration did not reverse the negative effects of type I diabetes on bone, suggesting that sitagliptin has no direct action on bone tissue and has no protective bone action in decompensated diabetic animals. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:29:43Z 2019-10-06T16:29:43Z 2019-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.archoralbio.2019.04.018 Archives of Oral Biology, v. 102, p. 238-243. 1879-1506 0003-9969 http://hdl.handle.net/11449/189098 10.1016/j.archoralbio.2019.04.018 2-s2.0-85065451721 |
url |
http://dx.doi.org/10.1016/j.archoralbio.2019.04.018 http://hdl.handle.net/11449/189098 |
identifier_str_mv |
Archives of Oral Biology, v. 102, p. 238-243. 1879-1506 0003-9969 10.1016/j.archoralbio.2019.04.018 2-s2.0-85065451721 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Oral Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
238-243 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129178744127488 |