Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.rvsc.2019.01.011 http://hdl.handle.net/11449/185588 |
Resumo: | Spinal cord injury (SCI) is a serious condition that causes profound economic and emotional impact in human patients and companion animal owners. It has been shown that the neurogenic effects of the stem cells are enhanced when combined with electroacupuncture (EA) in rodent models of SCI. To determine the safety and feasibility of combining transplantation of allogenic stem cells derived from canine exfoliated deciduous teeth (SCED) and EA in dogs with chronic spinal cord injury a canine pilot clinical study was conducted. A total of 16 individuals ranging from 5 to 11 years at 3 to 18 months of injury were investigated and randomly assigned to 4 experimental groups (SCED, EA, SCED + EA, control). Mild neurological and functional improvements were seen in all 4 groups. There was no clinical progression or mortality of the cases occurred in a follow up of 7 months after procedure. The study shows that SCED transplantation and electroacupuncture were feasible, safe and potentially beneficial. However Long-term patient monitoring is necessary to rule out any delayed side effects and assess any further improvements. |
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Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot studyIntervertebral disc herniationIntervertebral disc diseaseStem cells from exfoliated human dental pulpCell therapyElectroacupunctureSpinal cord injury (SCI) is a serious condition that causes profound economic and emotional impact in human patients and companion animal owners. It has been shown that the neurogenic effects of the stem cells are enhanced when combined with electroacupuncture (EA) in rodent models of SCI. To determine the safety and feasibility of combining transplantation of allogenic stem cells derived from canine exfoliated deciduous teeth (SCED) and EA in dogs with chronic spinal cord injury a canine pilot clinical study was conducted. A total of 16 individuals ranging from 5 to 11 years at 3 to 18 months of injury were investigated and randomly assigned to 4 experimental groups (SCED, EA, SCED + EA, control). Mild neurological and functional improvements were seen in all 4 groups. There was no clinical progression or mortality of the cases occurred in a follow up of 7 months after procedure. The study shows that SCED transplantation and electroacupuncture were feasible, safe and potentially beneficial. However Long-term patient monitoring is necessary to rule out any delayed side effects and assess any further improvements.National Institute of Science and Stem Cells Technology (INCTC-Brazil)Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Surg, Sao Paulo, BrazilNato Vet Clin, Sao Paulo, BrazilCoes & Gatos Anim Hosp, Osasco, BrazilBioeth Inst, Botucatu, SP, BrazilUniv Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USASao Paulo State Univ, Sch Vet Med & Anim Sci, Dept Vet Hyg & Publ Hlth, Botucatu, SP, BrazilStella Fisiovet Vet Physioterapy Clin, Sao Paulo, BrazilSao Paulo State Univ, Sch Vet Med & Anim Sci, Dept Vet Hyg & Publ Hlth, Botucatu, SP, BrazilNational Institute of Science and Stem Cells Technology (INCTC-Brazil): 2014/50947-7Elsevier B.V.Universidade de São Paulo (USP)Nato Vet ClinCoes & Gatos Anim HospBioeth InstUniv FloridaUniversidade Estadual Paulista (Unesp)Stella Fisiovet Vet Physioterapy ClinPrado, CesarFratini, PaulaSchiavo Matias, Gustavo de SaBocabello, Renato Z.Monteiro, JulianaSantos, Cello J. dosJoaquim, Jean G. F.Giglio, Robson F.Possebon, Fabio S. [UNESP]Sakata, Stella H.Miglino, Maria A.2019-10-04T12:36:47Z2019-10-04T12:36:47Z2019-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article247-251http://dx.doi.org/10.1016/j.rvsc.2019.01.011Research In Veterinary Science. Oxford: Elsevier Sci Ltd, v. 123, p. 247-251, 2019.0034-5288http://hdl.handle.net/11449/18558810.1016/j.rvsc.2019.01.011WOS:000463125600040Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengResearch In Veterinary Scienceinfo:eu-repo/semantics/openAccess2021-10-22T18:27:23Zoai:repositorio.unesp.br:11449/185588Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T18:27:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study |
title |
Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study |
spellingShingle |
Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study Prado, Cesar Intervertebral disc herniation Intervertebral disc disease Stem cells from exfoliated human dental pulp Cell therapy Electroacupuncture |
title_short |
Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study |
title_full |
Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study |
title_fullStr |
Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study |
title_full_unstemmed |
Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study |
title_sort |
Combination of stem cells from deciduous teeth and electroacupuncture for therapy in dogs with chronic spinal cord injury: A pilot study |
author |
Prado, Cesar |
author_facet |
Prado, Cesar Fratini, Paula Schiavo Matias, Gustavo de Sa Bocabello, Renato Z. Monteiro, Juliana Santos, Cello J. dos Joaquim, Jean G. F. Giglio, Robson F. Possebon, Fabio S. [UNESP] Sakata, Stella H. Miglino, Maria A. |
author_role |
author |
author2 |
Fratini, Paula Schiavo Matias, Gustavo de Sa Bocabello, Renato Z. Monteiro, Juliana Santos, Cello J. dos Joaquim, Jean G. F. Giglio, Robson F. Possebon, Fabio S. [UNESP] Sakata, Stella H. Miglino, Maria A. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Nato Vet Clin Coes & Gatos Anim Hosp Bioeth Inst Univ Florida Universidade Estadual Paulista (Unesp) Stella Fisiovet Vet Physioterapy Clin |
dc.contributor.author.fl_str_mv |
Prado, Cesar Fratini, Paula Schiavo Matias, Gustavo de Sa Bocabello, Renato Z. Monteiro, Juliana Santos, Cello J. dos Joaquim, Jean G. F. Giglio, Robson F. Possebon, Fabio S. [UNESP] Sakata, Stella H. Miglino, Maria A. |
dc.subject.por.fl_str_mv |
Intervertebral disc herniation Intervertebral disc disease Stem cells from exfoliated human dental pulp Cell therapy Electroacupuncture |
topic |
Intervertebral disc herniation Intervertebral disc disease Stem cells from exfoliated human dental pulp Cell therapy Electroacupuncture |
description |
Spinal cord injury (SCI) is a serious condition that causes profound economic and emotional impact in human patients and companion animal owners. It has been shown that the neurogenic effects of the stem cells are enhanced when combined with electroacupuncture (EA) in rodent models of SCI. To determine the safety and feasibility of combining transplantation of allogenic stem cells derived from canine exfoliated deciduous teeth (SCED) and EA in dogs with chronic spinal cord injury a canine pilot clinical study was conducted. A total of 16 individuals ranging from 5 to 11 years at 3 to 18 months of injury were investigated and randomly assigned to 4 experimental groups (SCED, EA, SCED + EA, control). Mild neurological and functional improvements were seen in all 4 groups. There was no clinical progression or mortality of the cases occurred in a follow up of 7 months after procedure. The study shows that SCED transplantation and electroacupuncture were feasible, safe and potentially beneficial. However Long-term patient monitoring is necessary to rule out any delayed side effects and assess any further improvements. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:36:47Z 2019-10-04T12:36:47Z 2019-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.rvsc.2019.01.011 Research In Veterinary Science. Oxford: Elsevier Sci Ltd, v. 123, p. 247-251, 2019. 0034-5288 http://hdl.handle.net/11449/185588 10.1016/j.rvsc.2019.01.011 WOS:000463125600040 |
url |
http://dx.doi.org/10.1016/j.rvsc.2019.01.011 http://hdl.handle.net/11449/185588 |
identifier_str_mv |
Research In Veterinary Science. Oxford: Elsevier Sci Ltd, v. 123, p. 247-251, 2019. 0034-5288 10.1016/j.rvsc.2019.01.011 WOS:000463125600040 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Research In Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
247-251 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649266048040960 |