Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.fct.2017.09.003 http://hdl.handle.net/11449/179170 |
Resumo: | Pediatric obesity is closely associated with dyslipidemias and environmental factors, such as diet and lack of physical exercises, which may alter lipid profile in children. Rosuvastatin decreases serum total cholesterol and triglycerides concentrations. Vitamin C (ascorbic acid) plays an important role on sperm integrity and fertility. Juvenile male rats were distributed into six experimental groups that received saline solution 0.9%, 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid from PND23 until PND53 and then the rats were maintained until sexual maturity. Rosuvastatin-exposed groups showed lower sperm quality, androgen depletion and germ cell death. Ascorbic acid was capable to prevent partially the reproductive adverse effects provoked by rosuvastatin. In conclusion, prepubertal exposure to rosuvastatin provokes long-term reproductive damages at sexual maturity and ascorbic acid supplementation at prepuberty may be a preventive mode against these reproductive adverse effects. |
id |
UNSP_b18cb40f34d211736ed9ca2b23b2e5e1 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/179170 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepubertyAscorbic acidMale reproductionRosuvastatinToxicologyPediatric obesity is closely associated with dyslipidemias and environmental factors, such as diet and lack of physical exercises, which may alter lipid profile in children. Rosuvastatin decreases serum total cholesterol and triglycerides concentrations. Vitamin C (ascorbic acid) plays an important role on sperm integrity and fertility. Juvenile male rats were distributed into six experimental groups that received saline solution 0.9%, 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid from PND23 until PND53 and then the rats were maintained until sexual maturity. Rosuvastatin-exposed groups showed lower sperm quality, androgen depletion and germ cell death. Ascorbic acid was capable to prevent partially the reproductive adverse effects provoked by rosuvastatin. In conclusion, prepubertal exposure to rosuvastatin provokes long-term reproductive damages at sexual maturity and ascorbic acid supplementation at prepuberty may be a preventive mode against these reproductive adverse effects.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Graduate Program in Cell and Structural Biology Institute of Biology State University of Campinas – UNICAMPDepartment of Morphology São Paulo State University (Unesp) Institute of BiosciencesGraduate Program in Genetics São Paulo State University (Unesp) Institute of BiosciencesDepartment of Morphology São Paulo State University (Unesp) Institute of BiosciencesGraduate Program in Genetics São Paulo State University (Unesp) Institute of BiosciencesFAPESP: #013/22495-1FAPESP: #014/13659-3CNPq: 308842/2013-8Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Leite, Gabriel Adan Araújo [UNESP]Figueiredo, Thamiris Moreira [UNESP]Pacheco, Tainá Louise [UNESP]Sanabria, Marciana [UNESP]Silva, Patrícia Villela e [UNESP]Fernandes, Fábio Henrique [UNESP]Kempinas, Wilma De Grava [UNESP]2018-12-11T17:34:04Z2018-12-11T17:34:04Z2017-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article272-283application/pdfhttp://dx.doi.org/10.1016/j.fct.2017.09.003Food and Chemical Toxicology, v. 109, p. 272-283.1873-63510278-6915http://hdl.handle.net/11449/17917010.1016/j.fct.2017.09.0032-s2.0-850293812862-s2.0-85029381286.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood and Chemical Toxicology1,144info:eu-repo/semantics/openAccess2023-10-10T06:09:11Zoai:repositorio.unesp.br:11449/179170Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:33:45.487779Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty |
title |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty |
spellingShingle |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty Leite, Gabriel Adan Araújo [UNESP] Ascorbic acid Male reproduction Rosuvastatin Toxicology |
title_short |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty |
title_full |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty |
title_fullStr |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty |
title_full_unstemmed |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty |
title_sort |
Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty |
author |
Leite, Gabriel Adan Araújo [UNESP] |
author_facet |
Leite, Gabriel Adan Araújo [UNESP] Figueiredo, Thamiris Moreira [UNESP] Pacheco, Tainá Louise [UNESP] Sanabria, Marciana [UNESP] Silva, Patrícia Villela e [UNESP] Fernandes, Fábio Henrique [UNESP] Kempinas, Wilma De Grava [UNESP] |
author_role |
author |
author2 |
Figueiredo, Thamiris Moreira [UNESP] Pacheco, Tainá Louise [UNESP] Sanabria, Marciana [UNESP] Silva, Patrícia Villela e [UNESP] Fernandes, Fábio Henrique [UNESP] Kempinas, Wilma De Grava [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Leite, Gabriel Adan Araújo [UNESP] Figueiredo, Thamiris Moreira [UNESP] Pacheco, Tainá Louise [UNESP] Sanabria, Marciana [UNESP] Silva, Patrícia Villela e [UNESP] Fernandes, Fábio Henrique [UNESP] Kempinas, Wilma De Grava [UNESP] |
dc.subject.por.fl_str_mv |
Ascorbic acid Male reproduction Rosuvastatin Toxicology |
topic |
Ascorbic acid Male reproduction Rosuvastatin Toxicology |
description |
Pediatric obesity is closely associated with dyslipidemias and environmental factors, such as diet and lack of physical exercises, which may alter lipid profile in children. Rosuvastatin decreases serum total cholesterol and triglycerides concentrations. Vitamin C (ascorbic acid) plays an important role on sperm integrity and fertility. Juvenile male rats were distributed into six experimental groups that received saline solution 0.9%, 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid from PND23 until PND53 and then the rats were maintained until sexual maturity. Rosuvastatin-exposed groups showed lower sperm quality, androgen depletion and germ cell death. Ascorbic acid was capable to prevent partially the reproductive adverse effects provoked by rosuvastatin. In conclusion, prepubertal exposure to rosuvastatin provokes long-term reproductive damages at sexual maturity and ascorbic acid supplementation at prepuberty may be a preventive mode against these reproductive adverse effects. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-01 2018-12-11T17:34:04Z 2018-12-11T17:34:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.fct.2017.09.003 Food and Chemical Toxicology, v. 109, p. 272-283. 1873-6351 0278-6915 http://hdl.handle.net/11449/179170 10.1016/j.fct.2017.09.003 2-s2.0-85029381286 2-s2.0-85029381286.pdf |
url |
http://dx.doi.org/10.1016/j.fct.2017.09.003 http://hdl.handle.net/11449/179170 |
identifier_str_mv |
Food and Chemical Toxicology, v. 109, p. 272-283. 1873-6351 0278-6915 10.1016/j.fct.2017.09.003 2-s2.0-85029381286 2-s2.0-85029381286.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Food and Chemical Toxicology 1,144 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
272-283 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128378492944384 |