Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100093&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/128672 |
Resumo: | Jatropha gossypiifolia L. (Euphorbiaceae), popularly known as cotton-leaf physicnut, is a milky shrub notable for its medicinal properties. The present study aimed to evaluate the toxic, cytotoxic and genotoxic effects of the latex of J. gossypiifolia, using Allium cepa L. as test system. Seeds of A. cepa were exposed to five concentrations of the latex (1.25; 2.5; 5; 10 and 20 mL/L) in order to evaluate parameters of toxicity (evaluation of root growth), cytotoxicity (mitotic index frequency) and genotoxicity (frequency of chromosome alterations). The latex showed a significant decrease in root mean growth value as well as mitotic index for the tested concentrations, except for 1.25 mL/L, when compared to results from the negative control. The 1.25, 2.5 and 5 mL/L concentrations induced significant chromosome adherences, C-metaphases and/or chromosome bridges, as genotoxic effects. The significant frequency of chromosome bridges also indicated mutagenic potential for chromosomes of J. gossypiifolia as discussed in the paper. Considering that the latex is used in popular therapies, and that the test system A. cepa presents good correlation with tests carried out in mammals, it can be pointed out that its use for medicinal purposes may be harmful to human health especially if ingested. |
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Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)Allium cepa testMedicinal plantPlant latexGenotoxicity evaluationJatropha gossypiifolia L. (Euphorbiaceae), popularly known as cotton-leaf physicnut, is a milky shrub notable for its medicinal properties. The present study aimed to evaluate the toxic, cytotoxic and genotoxic effects of the latex of J. gossypiifolia, using Allium cepa L. as test system. Seeds of A. cepa were exposed to five concentrations of the latex (1.25; 2.5; 5; 10 and 20 mL/L) in order to evaluate parameters of toxicity (evaluation of root growth), cytotoxicity (mitotic index frequency) and genotoxicity (frequency of chromosome alterations). The latex showed a significant decrease in root mean growth value as well as mitotic index for the tested concentrations, except for 1.25 mL/L, when compared to results from the negative control. The 1.25, 2.5 and 5 mL/L concentrations induced significant chromosome adherences, C-metaphases and/or chromosome bridges, as genotoxic effects. The significant frequency of chromosome bridges also indicated mutagenic potential for chromosomes of J. gossypiifolia as discussed in the paper. Considering that the latex is used in popular therapies, and that the test system A. cepa presents good correlation with tests carried out in mammals, it can be pointed out that its use for medicinal purposes may be harmful to human health especially if ingested.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco (FACEPE)Laboratório de Genética e Biotecnologia Vegetal, Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, BrazilLaboratório de Genética, Departamento de Saúde, Universidade Estadual do Piauí, Teresina, PI, Brazil.Laboratório de Mutagênese, Departamento de Biologia, Universidade Estadual Paulista “Júlio de Mesquita Filho”, Campus de Rio Claro, Rio Claro, SP, Brazil.Soc Brasil GeneticaUniversidade Federal de Pernambuco (UFPE)Universidade Estadual do Piauí (UESPI)Universidade Estadual Paulista (Unesp)Almeida, Pedro Marcos deAraujo, Silvany de SousaMarin-Morales, Maria Aparecida [UNESP]Benko-Iseppon, Ana MariaBrasileiro-Vidal, Ana Christina2015-10-21T13:12:08Z2015-10-21T13:12:08Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article93-100application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100093&lng=en&nrm=iso&tlng=enGenetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 38, n. 1, p. 93-100, 2015.1415-4757http://hdl.handle.net/11449/12867210.1590/S1415-475738120140162S1415-47572015000100093S1415-47572015000100093.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics And Molecular Biology1.4930,638info:eu-repo/semantics/openAccess2023-11-27T06:17:42Zoai:repositorio.unesp.br:11449/128672Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:53:22.364749Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.) |
title |
Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.) |
spellingShingle |
Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.) Almeida, Pedro Marcos de Allium cepa test Medicinal plant Plant latex Genotoxicity evaluation |
title_short |
Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.) |
title_full |
Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.) |
title_fullStr |
Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.) |
title_full_unstemmed |
Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.) |
title_sort |
Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.) |
author |
Almeida, Pedro Marcos de |
author_facet |
Almeida, Pedro Marcos de Araujo, Silvany de Sousa Marin-Morales, Maria Aparecida [UNESP] Benko-Iseppon, Ana Maria Brasileiro-Vidal, Ana Christina |
author_role |
author |
author2 |
Araujo, Silvany de Sousa Marin-Morales, Maria Aparecida [UNESP] Benko-Iseppon, Ana Maria Brasileiro-Vidal, Ana Christina |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Pernambuco (UFPE) Universidade Estadual do Piauí (UESPI) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Almeida, Pedro Marcos de Araujo, Silvany de Sousa Marin-Morales, Maria Aparecida [UNESP] Benko-Iseppon, Ana Maria Brasileiro-Vidal, Ana Christina |
dc.subject.por.fl_str_mv |
Allium cepa test Medicinal plant Plant latex Genotoxicity evaluation |
topic |
Allium cepa test Medicinal plant Plant latex Genotoxicity evaluation |
description |
Jatropha gossypiifolia L. (Euphorbiaceae), popularly known as cotton-leaf physicnut, is a milky shrub notable for its medicinal properties. The present study aimed to evaluate the toxic, cytotoxic and genotoxic effects of the latex of J. gossypiifolia, using Allium cepa L. as test system. Seeds of A. cepa were exposed to five concentrations of the latex (1.25; 2.5; 5; 10 and 20 mL/L) in order to evaluate parameters of toxicity (evaluation of root growth), cytotoxicity (mitotic index frequency) and genotoxicity (frequency of chromosome alterations). The latex showed a significant decrease in root mean growth value as well as mitotic index for the tested concentrations, except for 1.25 mL/L, when compared to results from the negative control. The 1.25, 2.5 and 5 mL/L concentrations induced significant chromosome adherences, C-metaphases and/or chromosome bridges, as genotoxic effects. The significant frequency of chromosome bridges also indicated mutagenic potential for chromosomes of J. gossypiifolia as discussed in the paper. Considering that the latex is used in popular therapies, and that the test system A. cepa presents good correlation with tests carried out in mammals, it can be pointed out that its use for medicinal purposes may be harmful to human health especially if ingested. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:12:08Z 2015-10-21T13:12:08Z 2015-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100093&lng=en&nrm=iso&tlng=en Genetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 38, n. 1, p. 93-100, 2015. 1415-4757 http://hdl.handle.net/11449/128672 10.1590/S1415-475738120140162 S1415-47572015000100093 S1415-47572015000100093.pdf |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100093&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/128672 |
identifier_str_mv |
Genetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 38, n. 1, p. 93-100, 2015. 1415-4757 10.1590/S1415-475738120140162 S1415-47572015000100093 S1415-47572015000100093.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics And Molecular Biology 1.493 0,638 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
93-100 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasil Genetica |
publisher.none.fl_str_mv |
Soc Brasil Genetica |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128996735451136 |