Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)

Detalhes bibliográficos
Autor(a) principal: Almeida, Pedro Marcos de
Data de Publicação: 2015
Outros Autores: Araujo, Silvany de Sousa, Marin-Morales, Maria Aparecida [UNESP], Benko-Iseppon, Ana Maria, Brasileiro-Vidal, Ana Christina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100093&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/128672
Resumo: Jatropha gossypiifolia L. (Euphorbiaceae), popularly known as cotton-leaf physicnut, is a milky shrub notable for its medicinal properties. The present study aimed to evaluate the toxic, cytotoxic and genotoxic effects of the latex of J. gossypiifolia, using Allium cepa L. as test system. Seeds of A. cepa were exposed to five concentrations of the latex (1.25; 2.5; 5; 10 and 20 mL/L) in order to evaluate parameters of toxicity (evaluation of root growth), cytotoxicity (mitotic index frequency) and genotoxicity (frequency of chromosome alterations). The latex showed a significant decrease in root mean growth value as well as mitotic index for the tested concentrations, except for 1.25 mL/L, when compared to results from the negative control. The 1.25, 2.5 and 5 mL/L concentrations induced significant chromosome adherences, C-metaphases and/or chromosome bridges, as genotoxic effects. The significant frequency of chromosome bridges also indicated mutagenic potential for chromosomes of J. gossypiifolia as discussed in the paper. Considering that the latex is used in popular therapies, and that the test system A. cepa presents good correlation with tests carried out in mammals, it can be pointed out that its use for medicinal purposes may be harmful to human health especially if ingested.
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spelling Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)Allium cepa testMedicinal plantPlant latexGenotoxicity evaluationJatropha gossypiifolia L. (Euphorbiaceae), popularly known as cotton-leaf physicnut, is a milky shrub notable for its medicinal properties. The present study aimed to evaluate the toxic, cytotoxic and genotoxic effects of the latex of J. gossypiifolia, using Allium cepa L. as test system. Seeds of A. cepa were exposed to five concentrations of the latex (1.25; 2.5; 5; 10 and 20 mL/L) in order to evaluate parameters of toxicity (evaluation of root growth), cytotoxicity (mitotic index frequency) and genotoxicity (frequency of chromosome alterations). The latex showed a significant decrease in root mean growth value as well as mitotic index for the tested concentrations, except for 1.25 mL/L, when compared to results from the negative control. The 1.25, 2.5 and 5 mL/L concentrations induced significant chromosome adherences, C-metaphases and/or chromosome bridges, as genotoxic effects. The significant frequency of chromosome bridges also indicated mutagenic potential for chromosomes of J. gossypiifolia as discussed in the paper. Considering that the latex is used in popular therapies, and that the test system A. cepa presents good correlation with tests carried out in mammals, it can be pointed out that its use for medicinal purposes may be harmful to human health especially if ingested.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco (FACEPE)Laboratório de Genética e Biotecnologia Vegetal, Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, BrazilLaboratório de Genética, Departamento de Saúde, Universidade Estadual do Piauí, Teresina, PI, Brazil.Laboratório de Mutagênese, Departamento de Biologia, Universidade Estadual Paulista “Júlio de Mesquita Filho”, Campus de Rio Claro, Rio Claro, SP, Brazil.Soc Brasil GeneticaUniversidade Federal de Pernambuco (UFPE)Universidade Estadual do Piauí (UESPI)Universidade Estadual Paulista (Unesp)Almeida, Pedro Marcos deAraujo, Silvany de SousaMarin-Morales, Maria Aparecida [UNESP]Benko-Iseppon, Ana MariaBrasileiro-Vidal, Ana Christina2015-10-21T13:12:08Z2015-10-21T13:12:08Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article93-100application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100093&lng=en&nrm=iso&tlng=enGenetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 38, n. 1, p. 93-100, 2015.1415-4757http://hdl.handle.net/11449/12867210.1590/S1415-475738120140162S1415-47572015000100093S1415-47572015000100093.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics And Molecular Biology1.4930,638info:eu-repo/semantics/openAccess2023-11-27T06:17:42Zoai:repositorio.unesp.br:11449/128672Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:53:22.364749Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
title Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
spellingShingle Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
Almeida, Pedro Marcos de
Allium cepa test
Medicinal plant
Plant latex
Genotoxicity evaluation
title_short Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
title_full Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
title_fullStr Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
title_full_unstemmed Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
title_sort Genotoxic potential of the latex from cotton-leaf physicnut (Jatropha gossypiifolia L.)
author Almeida, Pedro Marcos de
author_facet Almeida, Pedro Marcos de
Araujo, Silvany de Sousa
Marin-Morales, Maria Aparecida [UNESP]
Benko-Iseppon, Ana Maria
Brasileiro-Vidal, Ana Christina
author_role author
author2 Araujo, Silvany de Sousa
Marin-Morales, Maria Aparecida [UNESP]
Benko-Iseppon, Ana Maria
Brasileiro-Vidal, Ana Christina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Pernambuco (UFPE)
Universidade Estadual do Piauí (UESPI)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Almeida, Pedro Marcos de
Araujo, Silvany de Sousa
Marin-Morales, Maria Aparecida [UNESP]
Benko-Iseppon, Ana Maria
Brasileiro-Vidal, Ana Christina
dc.subject.por.fl_str_mv Allium cepa test
Medicinal plant
Plant latex
Genotoxicity evaluation
topic Allium cepa test
Medicinal plant
Plant latex
Genotoxicity evaluation
description Jatropha gossypiifolia L. (Euphorbiaceae), popularly known as cotton-leaf physicnut, is a milky shrub notable for its medicinal properties. The present study aimed to evaluate the toxic, cytotoxic and genotoxic effects of the latex of J. gossypiifolia, using Allium cepa L. as test system. Seeds of A. cepa were exposed to five concentrations of the latex (1.25; 2.5; 5; 10 and 20 mL/L) in order to evaluate parameters of toxicity (evaluation of root growth), cytotoxicity (mitotic index frequency) and genotoxicity (frequency of chromosome alterations). The latex showed a significant decrease in root mean growth value as well as mitotic index for the tested concentrations, except for 1.25 mL/L, when compared to results from the negative control. The 1.25, 2.5 and 5 mL/L concentrations induced significant chromosome adherences, C-metaphases and/or chromosome bridges, as genotoxic effects. The significant frequency of chromosome bridges also indicated mutagenic potential for chromosomes of J. gossypiifolia as discussed in the paper. Considering that the latex is used in popular therapies, and that the test system A. cepa presents good correlation with tests carried out in mammals, it can be pointed out that its use for medicinal purposes may be harmful to human health especially if ingested.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-21T13:12:08Z
2015-10-21T13:12:08Z
2015-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100093&lng=en&nrm=iso&tlng=en
Genetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 38, n. 1, p. 93-100, 2015.
1415-4757
http://hdl.handle.net/11449/128672
10.1590/S1415-475738120140162
S1415-47572015000100093
S1415-47572015000100093.pdf
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100093&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/128672
identifier_str_mv Genetics And Molecular Biology. Ribeirao Pret: Soc Brasil Genetica, v. 38, n. 1, p. 93-100, 2015.
1415-4757
10.1590/S1415-475738120140162
S1415-47572015000100093
S1415-47572015000100093.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics And Molecular Biology
1.493
0,638
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 93-100
application/pdf
dc.publisher.none.fl_str_mv Soc Brasil Genetica
publisher.none.fl_str_mv Soc Brasil Genetica
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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