Osseointegração de implantes de titânio recobertos com nanotubos e instalados sem estabilidade primária: influência da associação adesivo fibrínico/ácido tranexâmico

• Autor(a) principal: Capalbo, Bruna Cabrera [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149544; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-27/000866317.pdf
• topic: Implantes dentários; Osseointegração; Propriedades de superfície; Ácido tranexâmico

It is well known that the rate and strength of osseointegration is related to the direct connection between living bone and implant surface. Surface properties, such as topography, wettability, charge, surface energy, crystal structure, roughness, chemical potential, strain hardening, impurities, passive film thickness and coatings play important role for long-term clinical success. The association of fibrin-adhesive with tranexamic acid (TEA) is used to reduce fibrin degradation and prevent early blood clot breakdown. The aim of this study was to evaluate the bone healing around implants with anodized surface associated with fibrin adhesive/ tranexamic acid and installed with compromised primary stability. 80 implants of titanium ASTM F67 (Grade 4) with dimensions of 2.1 x 2.8mm Ø were manufactured. They were divided (n=10) into Group I (machined Ti), Group II (machined Ti / fibrin adhesive), Group III (machined Ti / tranexamic acid) Group IV (machined Ti / fibrin adhesive/tranexamic acid), Group V (anodized Ti), Group VI (anodized Ti / fibrin adhesive), Group VII (anodized Ti / tranexamic acid) Group VIII (anodized Ti / fibrin adhesive/tranexamic acid). The anodized surface was formed using glycerol electrolyte (glycerol DI-H2O) with DC fields 50-50 v / v and NH4F solution (0.5 to 1.5%) by applying a pulsed DC field to the specimen (10-20V) for a period of 3 hours at 37°C. The implants are surgically placed in tibia (defects with 2.5x3.2 mm Ø) of 80 male rats (250 grams). The surgical sites were rinse with 5%tranexamic acid solution in Groups III, IV, VII and VIII. In addition, were filled with fibrin adhesive into Groups II, IV, VI and VIII. The animals were euthanized at 45 days postoperative. The pieces were processed in methyl methacrylate (Stevenel's blue/Alizarin red). The samples were retrieved for bone-to-implant contact...