Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets

Detalhes bibliográficos
Autor(a) principal: Oliveira Junior, Silvio A. [UNESP]
Data de Publicação: 2010
Outros Autores: Pai-Silva, Maeli Dal, Martinez, Paula F. [UNESP], Campos, Dijon H. S. [UNESP], Lima-Leopoldo, Ana P. [UNESP], Leopoldo, André S. [UNESP], Nascimento, André F. [UNESP], Okoshi, Marina P. [UNESP], Okoshi, Katashi [UNESP], Padovani, Carlos R. [UNESP], Cicogna, Antonio C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/225974
Resumo: Background: This study tested whether rats with obesity induced by a hypercaloric diet (HD) present higher nutritional, endocrine, and cardiovascular disturbances compared with counterparts with obesity induced by overfeeding of a standard diet. An additional objective was to compare the isolated influence of HD on these parameters in lean and obese rats. Material/Methods: Twenty Wistar-Kyoto rats were distributed into four groups: CD-lean, CD-obese, HD-lean, and HDobese. CD (control diet) and HD groups received commercial standard chow and HD, respectively, for 20 weeks. The lean and obese groups included obesity-resistant and obesity-prone animals, respectively. Nutritional and metabolic evaluation involved measurement of calorie intake, dietary efficiency, body weight, adiposity, glycemia, triacylglycerol, insulin, and leptin. Cardiovascular evaluation included systolic blood pressure measurement, echocardiography, and analyses of myocardial morphology and myosin heavy-chain composition. Results: In both diets, obesity was characterized by increased adiposity, hyperleptinemia, hypertriacylglycerolemia, hyperinsulinemia, and cardiomyocyte nuclear hypertrophy. HD promoted hyperleptinemia and cardiac remodeling, characterized by nuclear and ventricular hypertrophy, as well as improved systolic performance in both the obesity-prone and obesity-resistant biotypes. In contrast to HD-lean, HD-obese rats presented more accentuated endocrine responses, including hyperglycemia, lower glycemic tolerance, and hyperleptinemia as well as interstitial fibrosis compared with the CD-obese animals. Conclusions: This study confirmed the primary hypothesis that rats with HD-induced obesity present more accentuated nutritional and endocrine disturbances compared with their counterparts with obesity resulting from overfeeding. In addition, dietary effects were more important between the obese groups, supporting evidence of an interaction between diet and biotype. © Med Sci Monit, 2010.
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spelling Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric dietsCardiac remodelingEndocrineHypercaloric dietObesityRatsBackground: This study tested whether rats with obesity induced by a hypercaloric diet (HD) present higher nutritional, endocrine, and cardiovascular disturbances compared with counterparts with obesity induced by overfeeding of a standard diet. An additional objective was to compare the isolated influence of HD on these parameters in lean and obese rats. Material/Methods: Twenty Wistar-Kyoto rats were distributed into four groups: CD-lean, CD-obese, HD-lean, and HDobese. CD (control diet) and HD groups received commercial standard chow and HD, respectively, for 20 weeks. The lean and obese groups included obesity-resistant and obesity-prone animals, respectively. Nutritional and metabolic evaluation involved measurement of calorie intake, dietary efficiency, body weight, adiposity, glycemia, triacylglycerol, insulin, and leptin. Cardiovascular evaluation included systolic blood pressure measurement, echocardiography, and analyses of myocardial morphology and myosin heavy-chain composition. Results: In both diets, obesity was characterized by increased adiposity, hyperleptinemia, hypertriacylglycerolemia, hyperinsulinemia, and cardiomyocyte nuclear hypertrophy. HD promoted hyperleptinemia and cardiac remodeling, characterized by nuclear and ventricular hypertrophy, as well as improved systolic performance in both the obesity-prone and obesity-resistant biotypes. In contrast to HD-lean, HD-obese rats presented more accentuated endocrine responses, including hyperglycemia, lower glycemic tolerance, and hyperleptinemia as well as interstitial fibrosis compared with the CD-obese animals. Conclusions: This study confirmed the primary hypothesis that rats with HD-induced obesity present more accentuated nutritional and endocrine disturbances compared with their counterparts with obesity resulting from overfeeding. In addition, dietary effects were more important between the obese groups, supporting evidence of an interaction between diet and biotype. © Med Sci Monit, 2010.Internal Medicine Department Botucatu Medical School São Paulo State University, BotucatuDepartment of Morphology Botucatu Biosciences Institute, BotucatuDepartment of Biostatistics Botucatu Biosciences Institute São Paulo State University, BotucatuInternal Medicine Department Botucatu Medical School São Paulo State University, BotucatuDepartment of Biostatistics Botucatu Biosciences Institute São Paulo State University, BotucatuUniversidade Estadual Paulista (UNESP)Botucatu Biosciences InstituteOliveira Junior, Silvio A. [UNESP]Pai-Silva, Maeli DalMartinez, Paula F. [UNESP]Campos, Dijon H. S. [UNESP]Lima-Leopoldo, Ana P. [UNESP]Leopoldo, André S. [UNESP]Nascimento, André F. [UNESP]Okoshi, Marina P. [UNESP]Okoshi, Katashi [UNESP]Padovani, Carlos R. [UNESP]Cicogna, Antonio C. [UNESP]2022-04-28T21:11:45Z2022-04-28T21:11:45Z2010-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article208-217Medical Science Monitor, v. 16, n. 7, p. 208-217, 2010.1234-10101643-3750http://hdl.handle.net/11449/2259742-s2.0-77954778633Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Science Monitorinfo:eu-repo/semantics/openAccess2024-08-14T17:22:48Zoai:repositorio.unesp.br:11449/225974Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:48Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
title Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
spellingShingle Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
Oliveira Junior, Silvio A. [UNESP]
Cardiac remodeling
Endocrine
Hypercaloric diet
Obesity
Rats
title_short Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
title_full Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
title_fullStr Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
title_full_unstemmed Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
title_sort Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets
author Oliveira Junior, Silvio A. [UNESP]
author_facet Oliveira Junior, Silvio A. [UNESP]
Pai-Silva, Maeli Dal
Martinez, Paula F. [UNESP]
Campos, Dijon H. S. [UNESP]
Lima-Leopoldo, Ana P. [UNESP]
Leopoldo, André S. [UNESP]
Nascimento, André F. [UNESP]
Okoshi, Marina P. [UNESP]
Okoshi, Katashi [UNESP]
Padovani, Carlos R. [UNESP]
Cicogna, Antonio C. [UNESP]
author_role author
author2 Pai-Silva, Maeli Dal
Martinez, Paula F. [UNESP]
Campos, Dijon H. S. [UNESP]
Lima-Leopoldo, Ana P. [UNESP]
Leopoldo, André S. [UNESP]
Nascimento, André F. [UNESP]
Okoshi, Marina P. [UNESP]
Okoshi, Katashi [UNESP]
Padovani, Carlos R. [UNESP]
Cicogna, Antonio C. [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Botucatu Biosciences Institute
dc.contributor.author.fl_str_mv Oliveira Junior, Silvio A. [UNESP]
Pai-Silva, Maeli Dal
Martinez, Paula F. [UNESP]
Campos, Dijon H. S. [UNESP]
Lima-Leopoldo, Ana P. [UNESP]
Leopoldo, André S. [UNESP]
Nascimento, André F. [UNESP]
Okoshi, Marina P. [UNESP]
Okoshi, Katashi [UNESP]
Padovani, Carlos R. [UNESP]
Cicogna, Antonio C. [UNESP]
dc.subject.por.fl_str_mv Cardiac remodeling
Endocrine
Hypercaloric diet
Obesity
Rats
topic Cardiac remodeling
Endocrine
Hypercaloric diet
Obesity
Rats
description Background: This study tested whether rats with obesity induced by a hypercaloric diet (HD) present higher nutritional, endocrine, and cardiovascular disturbances compared with counterparts with obesity induced by overfeeding of a standard diet. An additional objective was to compare the isolated influence of HD on these parameters in lean and obese rats. Material/Methods: Twenty Wistar-Kyoto rats were distributed into four groups: CD-lean, CD-obese, HD-lean, and HDobese. CD (control diet) and HD groups received commercial standard chow and HD, respectively, for 20 weeks. The lean and obese groups included obesity-resistant and obesity-prone animals, respectively. Nutritional and metabolic evaluation involved measurement of calorie intake, dietary efficiency, body weight, adiposity, glycemia, triacylglycerol, insulin, and leptin. Cardiovascular evaluation included systolic blood pressure measurement, echocardiography, and analyses of myocardial morphology and myosin heavy-chain composition. Results: In both diets, obesity was characterized by increased adiposity, hyperleptinemia, hypertriacylglycerolemia, hyperinsulinemia, and cardiomyocyte nuclear hypertrophy. HD promoted hyperleptinemia and cardiac remodeling, characterized by nuclear and ventricular hypertrophy, as well as improved systolic performance in both the obesity-prone and obesity-resistant biotypes. In contrast to HD-lean, HD-obese rats presented more accentuated endocrine responses, including hyperglycemia, lower glycemic tolerance, and hyperleptinemia as well as interstitial fibrosis compared with the CD-obese animals. Conclusions: This study confirmed the primary hypothesis that rats with HD-induced obesity present more accentuated nutritional and endocrine disturbances compared with their counterparts with obesity resulting from overfeeding. In addition, dietary effects were more important between the obese groups, supporting evidence of an interaction between diet and biotype. © Med Sci Monit, 2010.
publishDate 2010
dc.date.none.fl_str_mv 2010-07-01
2022-04-28T21:11:45Z
2022-04-28T21:11:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Medical Science Monitor, v. 16, n. 7, p. 208-217, 2010.
1234-1010
1643-3750
http://hdl.handle.net/11449/225974
2-s2.0-77954778633
identifier_str_mv Medical Science Monitor, v. 16, n. 7, p. 208-217, 2010.
1234-1010
1643-3750
2-s2.0-77954778633
url http://hdl.handle.net/11449/225974
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical Science Monitor
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 208-217
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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