Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.physa.2016.07.076 http://hdl.handle.net/11449/159105 |
Resumo: | Despite the current and increasingly successful fight against cancer, there are some important questions concerning the efficiency of its treatment in particular, the design of oncology chemotherapy protocols. Seeking efficiency, schedules based on more frequent, low-doses of drugs, known as metronomic chemotherapy, have been proposed as an alternative to the classical standard protocol of chemotherapy administration. The in silico approach may be very useful for providing a comparative analysis of these two kinds of protocols. In so doing, we found that metronomic schedules are more effective in eliminating tumour cells mainly due to their chemotherapeutic action on endothelial cells and that more frequent, low drug doses also entail outcomes in which the survival time of patient is increased. (C) 2016 Elsevier B.V. All rights reserved. |
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Repositório Institucional da UNESP |
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Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical modelCancerMetronomic chemotherapyAngiogenesisTumour growthDifferential equationsDespite the current and increasingly successful fight against cancer, there are some important questions concerning the efficiency of its treatment in particular, the design of oncology chemotherapy protocols. Seeking efficiency, schedules based on more frequent, low-doses of drugs, known as metronomic chemotherapy, have been proposed as an alternative to the classical standard protocol of chemotherapy administration. The in silico approach may be very useful for providing a comparative analysis of these two kinds of protocols. In so doing, we found that metronomic schedules are more effective in eliminating tumour cells mainly due to their chemotherapeutic action on endothelial cells and that more frequent, low drug doses also entail outcomes in which the survival time of patient is increased. (C) 2016 Elsevier B.V. All rights reserved.FAPESBINCT-CITECSConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, Inst Biociencias, BR-18618689 Botucatu, SP, BrazilUniv Fed Bahia, Inst Fis, BR-40210340 Salvador, BA, BrazilUniv Estadual Paulista, Inst Biociencias, BR-18618689 Botucatu, SP, BrazilFAPESB: PNX 0006/2009INCT-CITECS: 57386/2008-9CNPq: 305176/2009-9Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade Federal da Bahia (UFBA)Rodrigues, Diego S. [UNESP]Mancera, Paulo F. A. [UNESP]Pinho, Suani T. R.2018-11-26T15:31:24Z2018-11-26T15:31:24Z2016-12-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article251-266application/pdfhttp://dx.doi.org/10.1016/j.physa.2016.07.076Physica A-statistical Mechanics And Its Applications. Amsterdam: Elsevier Science Bv, v. 464, p. 251-266, 2016.0378-4371http://hdl.handle.net/11449/15910510.1016/j.physa.2016.07.076WOS:000384382600021WOS000384382600021.pdf82322894121087230000-0002-2080-8053Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysica A-statistical Mechanics And Its Applications0,773info:eu-repo/semantics/openAccess2023-10-05T06:07:09Zoai:repositorio.unesp.br:11449/159105Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:05:40.277807Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model |
title |
Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model |
spellingShingle |
Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model Rodrigues, Diego S. [UNESP] Cancer Metronomic chemotherapy Angiogenesis Tumour growth Differential equations |
title_short |
Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model |
title_full |
Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model |
title_fullStr |
Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model |
title_full_unstemmed |
Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model |
title_sort |
Understanding the antiangiogenic effect of metronomic chemotherapy through a simple mathematical model |
author |
Rodrigues, Diego S. [UNESP] |
author_facet |
Rodrigues, Diego S. [UNESP] Mancera, Paulo F. A. [UNESP] Pinho, Suani T. R. |
author_role |
author |
author2 |
Mancera, Paulo F. A. [UNESP] Pinho, Suani T. R. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal da Bahia (UFBA) |
dc.contributor.author.fl_str_mv |
Rodrigues, Diego S. [UNESP] Mancera, Paulo F. A. [UNESP] Pinho, Suani T. R. |
dc.subject.por.fl_str_mv |
Cancer Metronomic chemotherapy Angiogenesis Tumour growth Differential equations |
topic |
Cancer Metronomic chemotherapy Angiogenesis Tumour growth Differential equations |
description |
Despite the current and increasingly successful fight against cancer, there are some important questions concerning the efficiency of its treatment in particular, the design of oncology chemotherapy protocols. Seeking efficiency, schedules based on more frequent, low-doses of drugs, known as metronomic chemotherapy, have been proposed as an alternative to the classical standard protocol of chemotherapy administration. The in silico approach may be very useful for providing a comparative analysis of these two kinds of protocols. In so doing, we found that metronomic schedules are more effective in eliminating tumour cells mainly due to their chemotherapeutic action on endothelial cells and that more frequent, low drug doses also entail outcomes in which the survival time of patient is increased. (C) 2016 Elsevier B.V. All rights reserved. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-15 2018-11-26T15:31:24Z 2018-11-26T15:31:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.physa.2016.07.076 Physica A-statistical Mechanics And Its Applications. Amsterdam: Elsevier Science Bv, v. 464, p. 251-266, 2016. 0378-4371 http://hdl.handle.net/11449/159105 10.1016/j.physa.2016.07.076 WOS:000384382600021 WOS000384382600021.pdf 8232289412108723 0000-0002-2080-8053 |
url |
http://dx.doi.org/10.1016/j.physa.2016.07.076 http://hdl.handle.net/11449/159105 |
identifier_str_mv |
Physica A-statistical Mechanics And Its Applications. Amsterdam: Elsevier Science Bv, v. 464, p. 251-266, 2016. 0378-4371 10.1016/j.physa.2016.07.076 WOS:000384382600021 WOS000384382600021.pdf 8232289412108723 0000-0002-2080-8053 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physica A-statistical Mechanics And Its Applications 0,773 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
251-266 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128315141128192 |