Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis

Detalhes bibliográficos
Autor(a) principal: de Castro Ferreira Lima, Mayra [UNESP]
Data de Publicação: 2019
Outros Autores: Bornhousen Cardoso de Araújo, Juliana [UNESP], Paes, Antonio Carlos [UNESP], Gianfrancesco Filippi, Mauricio [UNESP], Cruz-Aleixo, Amanda Sarita [UNESP], Kiomi Takahira, Regina [UNESP], Gomes Lourenço, Maria Lucia [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1053/j.tcam.2019.03.005
http://hdl.handle.net/11449/188997
Resumo: Canine Monocytic Ehrlichiosis (CME) is a disease of worldwide distribution caused by the bacteria Ehrlichia canis, appearing primarily in hot climates due to the massive prevalence of its vector, the tick Rhipicephalus sanguineus. Previous studies have shown that dogs afflicted by CME in the chronic phase can develop infectious myocarditis, arrhythmias, and alterations in heart rate variability (HRV), but there are few studies correlating cardiac diseases with the acute phase of CME. This study aims at assessing electric cardiac alterations and HRV in the time and frequency domains during the acute phase of CME. This study assessed 22 animals divided into 2 distinct groups: the control group, comprised by 10 healthy dogs, and the sick group, comprised of 12 dogs infected naturally with ehrlichiosis which presented clinical and hematological signs compatible with the acute phase of the disease. The animals underwent conventional and Holter electrocardiographic evaluations, systolic blood pressure measurement, complete blood count and biochemical assays (urea, creatinine, alanine aminotransferase (ALT), alkaline phosphatase (AP), and gamma glutamyl transferase (GGT)). The sick group presented higher activity in the sympathetic nervous system than in the parasympathetic nervous system, manifest as a significant increase in mean heart rate and a reduction in the HRV indexes for the time and frequency domains. The frequency-domain HRV indexes presented sympathetic prevalence during the sleep and vigilance states. Sinus tachycardia was the predominant heart rhythm in 58.33% of the animals. The mean systolic blood pressure diverged between the groups and no significant arrhythmias were observed during monitoring. The serum concentrations of urea, creatinine, AP, ALT, and GGT were within the established reference values for the species. We observed no indication that there was enough time during the acute phase for the disease to evolve in a way that resulted in arrhythmias, as is common in the chronic phase, but we observed that animals in the acute phase already present reduced HRV indexes.
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spelling Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosisautonomic tonusdogsheart rate variabilitymyocarditisCanine Monocytic Ehrlichiosis (CME) is a disease of worldwide distribution caused by the bacteria Ehrlichia canis, appearing primarily in hot climates due to the massive prevalence of its vector, the tick Rhipicephalus sanguineus. Previous studies have shown that dogs afflicted by CME in the chronic phase can develop infectious myocarditis, arrhythmias, and alterations in heart rate variability (HRV), but there are few studies correlating cardiac diseases with the acute phase of CME. This study aims at assessing electric cardiac alterations and HRV in the time and frequency domains during the acute phase of CME. This study assessed 22 animals divided into 2 distinct groups: the control group, comprised by 10 healthy dogs, and the sick group, comprised of 12 dogs infected naturally with ehrlichiosis which presented clinical and hematological signs compatible with the acute phase of the disease. The animals underwent conventional and Holter electrocardiographic evaluations, systolic blood pressure measurement, complete blood count and biochemical assays (urea, creatinine, alanine aminotransferase (ALT), alkaline phosphatase (AP), and gamma glutamyl transferase (GGT)). The sick group presented higher activity in the sympathetic nervous system than in the parasympathetic nervous system, manifest as a significant increase in mean heart rate and a reduction in the HRV indexes for the time and frequency domains. The frequency-domain HRV indexes presented sympathetic prevalence during the sleep and vigilance states. Sinus tachycardia was the predominant heart rhythm in 58.33% of the animals. The mean systolic blood pressure diverged between the groups and no significant arrhythmias were observed during monitoring. The serum concentrations of urea, creatinine, AP, ALT, and GGT were within the established reference values for the species. We observed no indication that there was enough time during the acute phase for the disease to evolve in a way that resulted in arrhythmias, as is common in the chronic phase, but we observed that animals in the acute phase already present reduced HRV indexes.Department of Veterinary Hygiene and Public Health São Paulo State University (Unesp) School of Veterinary Medicine and Animal ScienceVeterinary Clinic Department São Paulo State University (Unesp) School of Veterinary Medicine and Animal ScienceDepartment of Veterinary Hygiene and Public Health São Paulo State University (Unesp) School of Veterinary Medicine and Animal ScienceVeterinary Clinic Department São Paulo State University (Unesp) School of Veterinary Medicine and Animal ScienceUniversidade Estadual Paulista (Unesp)de Castro Ferreira Lima, Mayra [UNESP]Bornhousen Cardoso de Araújo, Juliana [UNESP]Paes, Antonio Carlos [UNESP]Gianfrancesco Filippi, Mauricio [UNESP]Cruz-Aleixo, Amanda Sarita [UNESP]Kiomi Takahira, Regina [UNESP]Gomes Lourenço, Maria Lucia [UNESP]2019-10-06T16:26:24Z2019-10-06T16:26:24Z2019-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article31-37http://dx.doi.org/10.1053/j.tcam.2019.03.005Topics in Companion Animal Medicine, v. 35, p. 31-37.1938-9736http://hdl.handle.net/11449/18899710.1053/j.tcam.2019.03.0052-s2.0-85064492491Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTopics in Companion Animal Medicineinfo:eu-repo/semantics/openAccess2021-10-22T21:54:38Zoai:repositorio.unesp.br:11449/188997Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T21:54:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis
title Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis
spellingShingle Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis
de Castro Ferreira Lima, Mayra [UNESP]
autonomic tonus
dogs
heart rate variability
myocarditis
title_short Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis
title_full Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis
title_fullStr Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis
title_full_unstemmed Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis
title_sort Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis
author de Castro Ferreira Lima, Mayra [UNESP]
author_facet de Castro Ferreira Lima, Mayra [UNESP]
Bornhousen Cardoso de Araújo, Juliana [UNESP]
Paes, Antonio Carlos [UNESP]
Gianfrancesco Filippi, Mauricio [UNESP]
Cruz-Aleixo, Amanda Sarita [UNESP]
Kiomi Takahira, Regina [UNESP]
Gomes Lourenço, Maria Lucia [UNESP]
author_role author
author2 Bornhousen Cardoso de Araújo, Juliana [UNESP]
Paes, Antonio Carlos [UNESP]
Gianfrancesco Filippi, Mauricio [UNESP]
Cruz-Aleixo, Amanda Sarita [UNESP]
Kiomi Takahira, Regina [UNESP]
Gomes Lourenço, Maria Lucia [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Castro Ferreira Lima, Mayra [UNESP]
Bornhousen Cardoso de Araújo, Juliana [UNESP]
Paes, Antonio Carlos [UNESP]
Gianfrancesco Filippi, Mauricio [UNESP]
Cruz-Aleixo, Amanda Sarita [UNESP]
Kiomi Takahira, Regina [UNESP]
Gomes Lourenço, Maria Lucia [UNESP]
dc.subject.por.fl_str_mv autonomic tonus
dogs
heart rate variability
myocarditis
topic autonomic tonus
dogs
heart rate variability
myocarditis
description Canine Monocytic Ehrlichiosis (CME) is a disease of worldwide distribution caused by the bacteria Ehrlichia canis, appearing primarily in hot climates due to the massive prevalence of its vector, the tick Rhipicephalus sanguineus. Previous studies have shown that dogs afflicted by CME in the chronic phase can develop infectious myocarditis, arrhythmias, and alterations in heart rate variability (HRV), but there are few studies correlating cardiac diseases with the acute phase of CME. This study aims at assessing electric cardiac alterations and HRV in the time and frequency domains during the acute phase of CME. This study assessed 22 animals divided into 2 distinct groups: the control group, comprised by 10 healthy dogs, and the sick group, comprised of 12 dogs infected naturally with ehrlichiosis which presented clinical and hematological signs compatible with the acute phase of the disease. The animals underwent conventional and Holter electrocardiographic evaluations, systolic blood pressure measurement, complete blood count and biochemical assays (urea, creatinine, alanine aminotransferase (ALT), alkaline phosphatase (AP), and gamma glutamyl transferase (GGT)). The sick group presented higher activity in the sympathetic nervous system than in the parasympathetic nervous system, manifest as a significant increase in mean heart rate and a reduction in the HRV indexes for the time and frequency domains. The frequency-domain HRV indexes presented sympathetic prevalence during the sleep and vigilance states. Sinus tachycardia was the predominant heart rhythm in 58.33% of the animals. The mean systolic blood pressure diverged between the groups and no significant arrhythmias were observed during monitoring. The serum concentrations of urea, creatinine, AP, ALT, and GGT were within the established reference values for the species. We observed no indication that there was enough time during the acute phase for the disease to evolve in a way that resulted in arrhythmias, as is common in the chronic phase, but we observed that animals in the acute phase already present reduced HRV indexes.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:26:24Z
2019-10-06T16:26:24Z
2019-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1053/j.tcam.2019.03.005
Topics in Companion Animal Medicine, v. 35, p. 31-37.
1938-9736
http://hdl.handle.net/11449/188997
10.1053/j.tcam.2019.03.005
2-s2.0-85064492491
url http://dx.doi.org/10.1053/j.tcam.2019.03.005
http://hdl.handle.net/11449/188997
identifier_str_mv Topics in Companion Animal Medicine, v. 35, p. 31-37.
1938-9736
10.1053/j.tcam.2019.03.005
2-s2.0-85064492491
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Topics in Companion Animal Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 31-37
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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