Florid cemento-osseous dysplasia-related osteonecrosis: A series of cases

• Autor(a) principal: Bastos, Yann Victor Paiva
• Data de Publicação: 2022
• Outros Autores: Carlos, Roman, Oliveira, Paulo Tambasco De, Pires, Bruno Cunha, Cangussu, Maria Cristina Teixeira, Xavier, Flávia Caló Aquino, Koga-Ito, Cristiane Yumi [UNESP], Manieri, Patricia Rubia, Souza, André Sampaio, Júnior, Braúlio Carneiro, Ramalho, Luciana Maria Pedreira, Cury, Patrícia Ramos, Santos, Jean Nunes Dos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.anndiagpath.2022.152009; http://hdl.handle.net/11449/242071
• topic: Cemento-osseous dysplasia; Mandible; Osteonecrosis

Objective: The aim of this study was to assess the clinicopathological features of florid cemento-osseous dysplasia (FCOD)-related osteonecrosis highlighting their histopathological aspects and bone structure. Methods: Twenty-two FCOD-related osteonecrosis cases were evaluated retrospectively. Osteonecrosis, osteomyelitis, bacterial colonization, bone resorption, reactive bone, osteon-like structure, lamellar bone, and basophilic lines were analyzed. Specific staining and fluorescence and polarized light microscopy analyses were also performed. Results: The mandible was more affected by FCOD-related osteonecrosis. There was a predominance of African-Brazilian women in the fifth and seventh decades of life. Osteomyelitis was present in 82 % of cases whereas bone resorption and bacterial colonization were present in 100 % of FCOD-related osteonecrosis cases. Thick basophilic lines were seen in all cases (100 %). Actinomycosis and osteoclasts were not often. Conclusions: This study showed female adult preference, mandibular location, and some findings such as osteomyelitis, bone resorption, and bacterial colonization were histopathological features more frequent in FCOD-related osteonecrosis. In the absence of a close clinical and radiographic correlation, the morphology of the necrotized bone similar to cementum could help to recognize FCOD.