Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor

Detalhes bibliográficos
Autor(a) principal: Santos, Daniela Pereira dos [UNESP]
Data de Publicação: 2010
Outros Autores: Bergamini, Marcio Fernando, Zanoni, Maria Valnice Boldrin [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.electrochemsci.org/papers/vol5/5101399.pdf
http://hdl.handle.net/11449/25980
Resumo: The poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and the side chain carboxyl groups of branched PGA film and it is the base to develop a simple voltammetric sensor for the determination of doxorubicin in human urine. The preconcentration of DXR on the modified electrode occurs under open circuit and studied by the methods of square wave voltammetry to monitor the drug. Standard curves were linear over the concentration range of 2.20 - 44.5 mu mol L(-1) giving a detection limit of 0.45 mu mol L(-1) show that the proposed sensor is suitable for doxorubicin determination in real samples.
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spelling Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric SensorDoxorubicinpoly-L-glutamic acidadsorptionsemiquinone free radicalurineThe poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and the side chain carboxyl groups of branched PGA film and it is the base to develop a simple voltammetric sensor for the determination of doxorubicin in human urine. The preconcentration of DXR on the modified electrode occurs under open circuit and studied by the methods of square wave voltammetry to monitor the drug. Standard curves were linear over the concentration range of 2.20 - 44.5 mu mol L(-1) giving a detection limit of 0.45 mu mol L(-1) show that the proposed sensor is suitable for doxorubicin determination in real samples.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ São Paulo State, Inst Chem, UNESP, BR-14801970 Araraquara, SP, BrazilUFPR, Ctr Politecn, Setor Ciencias Exatas, Dept Quim, BR-81531990 Curitiba, Parana, BrazilUniv São Paulo State, Inst Chem, UNESP, BR-14801970 Araraquara, SP, BrazilFAPESP: 3/06598-3FAPESP: 04/00111-8Electrochemical Science GroupUniversidade Estadual Paulista (Unesp)Universidade Federal do Paraná (UFPR)Santos, Daniela Pereira dos [UNESP]Bergamini, Marcio FernandoZanoni, Maria Valnice Boldrin [UNESP]2014-05-20T14:19:53Z2014-05-20T14:19:53Z2010-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1399-1410application/pdfhttp://www.electrochemsci.org/papers/vol5/5101399.pdfInternational Journal of Electrochemical Science. Belgrade: Electrochemical Science Group, v. 5, n. 10, p. 1399-1410, 2010.1452-3981http://hdl.handle.net/11449/25980WOS:000282329800001WOS000282329800001.pdf0000-0002-2296-1393Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Electrochemical Science1.3690,366info:eu-repo/semantics/openAccess2023-10-28T06:06:10Zoai:repositorio.unesp.br:11449/25980Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:13:39.704616Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
title Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
spellingShingle Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
Santos, Daniela Pereira dos [UNESP]
Doxorubicin
poly-L-glutamic acid
adsorption
semiquinone free radical
urine
title_short Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
title_full Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
title_fullStr Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
title_full_unstemmed Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
title_sort Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
author Santos, Daniela Pereira dos [UNESP]
author_facet Santos, Daniela Pereira dos [UNESP]
Bergamini, Marcio Fernando
Zanoni, Maria Valnice Boldrin [UNESP]
author_role author
author2 Bergamini, Marcio Fernando
Zanoni, Maria Valnice Boldrin [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal do Paraná (UFPR)
dc.contributor.author.fl_str_mv Santos, Daniela Pereira dos [UNESP]
Bergamini, Marcio Fernando
Zanoni, Maria Valnice Boldrin [UNESP]
dc.subject.por.fl_str_mv Doxorubicin
poly-L-glutamic acid
adsorption
semiquinone free radical
urine
topic Doxorubicin
poly-L-glutamic acid
adsorption
semiquinone free radical
urine
description The poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and the side chain carboxyl groups of branched PGA film and it is the base to develop a simple voltammetric sensor for the determination of doxorubicin in human urine. The preconcentration of DXR on the modified electrode occurs under open circuit and studied by the methods of square wave voltammetry to monitor the drug. Standard curves were linear over the concentration range of 2.20 - 44.5 mu mol L(-1) giving a detection limit of 0.45 mu mol L(-1) show that the proposed sensor is suitable for doxorubicin determination in real samples.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
2014-05-20T14:19:53Z
2014-05-20T14:19:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.electrochemsci.org/papers/vol5/5101399.pdf
International Journal of Electrochemical Science. Belgrade: Electrochemical Science Group, v. 5, n. 10, p. 1399-1410, 2010.
1452-3981
http://hdl.handle.net/11449/25980
WOS:000282329800001
WOS000282329800001.pdf
0000-0002-2296-1393
url http://www.electrochemsci.org/papers/vol5/5101399.pdf
http://hdl.handle.net/11449/25980
identifier_str_mv International Journal of Electrochemical Science. Belgrade: Electrochemical Science Group, v. 5, n. 10, p. 1399-1410, 2010.
1452-3981
WOS:000282329800001
WOS000282329800001.pdf
0000-0002-2296-1393
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Electrochemical Science
1.369
0,366
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1399-1410
application/pdf
dc.publisher.none.fl_str_mv Electrochemical Science Group
publisher.none.fl_str_mv Electrochemical Science Group
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128621748944896

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