Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters
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Publication Date: | 2022 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1038/s41598-022-23418-z http://hdl.handle.net/11449/249384 |
Summary: | The expansion of the sheep model in research represents an attractive and economically beneficial academic reason for investigations in sheep echocardiography. The present study aimed to evaluate the clinical and echocardiographic parameters in Dorper lambs during the developmental period. Emphasis was placed on the use of the species in translational research for the echocardiographic diagnosis of congenital heart diseases, which can contribute to improvements in interventionist techniques. Ten Dorper lambs were evaluated at the following time points: 24 h after birth and 7, 14, 21, 30, 60, 90 and 120 days of age. Clinical parameters were compiled, and echocardiogram records were obtained without sedation. Rectal temperature was lower on the first day compared to the others. From 21 days of life, there was a reduction in HR, with differences between time points. Mean and systolic blood pressure differed, with the highest values at 90 and 120 days of age. The thickness of the interventricular septum in diastole (IVSd) increased as age progressed, with the highest value at 120 days of age, and the same occurred for LVIDd (left ventricle internal diameter in diastole), LVFWd (left ventricular free wall thickness in diastole), IVSs (interventricular septum thickness in systole), LVIDs (left ventricle internal diameter in systole) and LVFWs (left ventricular free wall thickness in systole). There were differences in the size of the LA, Ao and LA/Ao ratio, which were greater at 90 days and 120 days of age. Echocardiographic changes accompany the development of lambs, where changes in echocardiographic parameters are evident with advancing age. The echocardiographic measurements in lambs obtained in the present study are similar to those in newborns. |
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Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parametersThe expansion of the sheep model in research represents an attractive and economically beneficial academic reason for investigations in sheep echocardiography. The present study aimed to evaluate the clinical and echocardiographic parameters in Dorper lambs during the developmental period. Emphasis was placed on the use of the species in translational research for the echocardiographic diagnosis of congenital heart diseases, which can contribute to improvements in interventionist techniques. Ten Dorper lambs were evaluated at the following time points: 24 h after birth and 7, 14, 21, 30, 60, 90 and 120 days of age. Clinical parameters were compiled, and echocardiogram records were obtained without sedation. Rectal temperature was lower on the first day compared to the others. From 21 days of life, there was a reduction in HR, with differences between time points. Mean and systolic blood pressure differed, with the highest values at 90 and 120 days of age. The thickness of the interventricular septum in diastole (IVSd) increased as age progressed, with the highest value at 120 days of age, and the same occurred for LVIDd (left ventricle internal diameter in diastole), LVFWd (left ventricular free wall thickness in diastole), IVSs (interventricular septum thickness in systole), LVIDs (left ventricle internal diameter in systole) and LVFWs (left ventricular free wall thickness in systole). There were differences in the size of the LA, Ao and LA/Ao ratio, which were greater at 90 days and 120 days of age. Echocardiographic changes accompany the development of lambs, where changes in echocardiographic parameters are evident with advancing age. The echocardiographic measurements in lambs obtained in the present study are similar to those in newborns.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)School of Veterinary Medicine and Animal Science São Paulo State University (Unesp), São PauloSecretary of Agriculture and Supply of the State of São Paulo - SAA/SP Coordination of Agricultural Defense - CDA Office of Agricultural Defense of Bauru - EDAInstitute of Biosciences São Paulo State University (Unesp), São PauloSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp) Rua Prof. Doutor Walter Mauricio Correa, São Paulo, S/N Bairro: Unesp Campus de BotucatuSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp), São PauloInstitute of Biosciences São Paulo State University (Unesp), São PauloSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp) Rua Prof. Doutor Walter Mauricio Correa, São Paulo, S/N Bairro: Unesp Campus de BotucatuFAPESP: 2017/15121-9Universidade Estadual Paulista (UNESP)Office of Agricultural Defense of Bauru - EDAAleixo, Amanda Sarita Cruz [UNESP]Ferreira, Danilo Otávio LaurentiTsunemi, Miriam Harumi [UNESP]Chiacchio, Simone Biagio [UNESP]Lourenço, Maria Lucia Gomes [UNESP]2023-07-29T15:14:40Z2023-07-29T15:14:40Z2022-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-022-23418-zScientific Reports, v. 12, n. 1, 2022.2045-2322http://hdl.handle.net/11449/24938410.1038/s41598-022-23418-z2-s2.0-85142165335Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reportsinfo:eu-repo/semantics/openAccess2023-07-29T15:14:40Zoai:repositorio.unesp.br:11449/249384Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T15:14:40Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters |
title |
Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters |
spellingShingle |
Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters Aleixo, Amanda Sarita Cruz [UNESP] |
title_short |
Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters |
title_full |
Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters |
title_fullStr |
Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters |
title_full_unstemmed |
Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters |
title_sort |
Influence of Dorper lamb development from birth to 120 days of age on clinical and echocardiographic parameters |
author |
Aleixo, Amanda Sarita Cruz [UNESP] |
author_facet |
Aleixo, Amanda Sarita Cruz [UNESP] Ferreira, Danilo Otávio Laurenti Tsunemi, Miriam Harumi [UNESP] Chiacchio, Simone Biagio [UNESP] Lourenço, Maria Lucia Gomes [UNESP] |
author_role |
author |
author2 |
Ferreira, Danilo Otávio Laurenti Tsunemi, Miriam Harumi [UNESP] Chiacchio, Simone Biagio [UNESP] Lourenço, Maria Lucia Gomes [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Office of Agricultural Defense of Bauru - EDA |
dc.contributor.author.fl_str_mv |
Aleixo, Amanda Sarita Cruz [UNESP] Ferreira, Danilo Otávio Laurenti Tsunemi, Miriam Harumi [UNESP] Chiacchio, Simone Biagio [UNESP] Lourenço, Maria Lucia Gomes [UNESP] |
description |
The expansion of the sheep model in research represents an attractive and economically beneficial academic reason for investigations in sheep echocardiography. The present study aimed to evaluate the clinical and echocardiographic parameters in Dorper lambs during the developmental period. Emphasis was placed on the use of the species in translational research for the echocardiographic diagnosis of congenital heart diseases, which can contribute to improvements in interventionist techniques. Ten Dorper lambs were evaluated at the following time points: 24 h after birth and 7, 14, 21, 30, 60, 90 and 120 days of age. Clinical parameters were compiled, and echocardiogram records were obtained without sedation. Rectal temperature was lower on the first day compared to the others. From 21 days of life, there was a reduction in HR, with differences between time points. Mean and systolic blood pressure differed, with the highest values at 90 and 120 days of age. The thickness of the interventricular septum in diastole (IVSd) increased as age progressed, with the highest value at 120 days of age, and the same occurred for LVIDd (left ventricle internal diameter in diastole), LVFWd (left ventricular free wall thickness in diastole), IVSs (interventricular septum thickness in systole), LVIDs (left ventricle internal diameter in systole) and LVFWs (left ventricular free wall thickness in systole). There were differences in the size of the LA, Ao and LA/Ao ratio, which were greater at 90 days and 120 days of age. Echocardiographic changes accompany the development of lambs, where changes in echocardiographic parameters are evident with advancing age. The echocardiographic measurements in lambs obtained in the present study are similar to those in newborns. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-01 2023-07-29T15:14:40Z 2023-07-29T15:14:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-022-23418-z Scientific Reports, v. 12, n. 1, 2022. 2045-2322 http://hdl.handle.net/11449/249384 10.1038/s41598-022-23418-z 2-s2.0-85142165335 |
url |
http://dx.doi.org/10.1038/s41598-022-23418-z http://hdl.handle.net/11449/249384 |
identifier_str_mv |
Scientific Reports, v. 12, n. 1, 2022. 2045-2322 10.1038/s41598-022-23418-z 2-s2.0-85142165335 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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