Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0103-6440202204808 http://hdl.handle.net/11449/241537 |
Resumo: | This study synthesized and tested experimental gels containing fluoride (F-) and stannous (Sn2+) ions for the control of dental erosion. Enamel and dentin polished specimens were eroded (1% citric acid solution, 10 min) and randomly allocated into 5 groups (n=10): Placebo-Hydroxypropyl Methylcellulose (HMC) gel; F+Sn+HMC-7,500 ppm F- / 15,000 ppm Sn2+; F+HMC-7,500 ppm F-; Commercial acidulated phosphate fluoride gel (12,300 ppm F-); and Control-no treatment. After treatment (applied for 60 s), specimens underwent an erosion-remineralization cycling (5 min in 0.3% citric acid solution, 60 min in artificial saliva, 4×/day, 20 days). Surface loss (SL, in µm) was determined after the 5th, 10th and 20th days of cycling (α=0.05). For enamel, after 5 and 10 days, F+Sn+HMC presented the lowest SL, which did not differ from the commercial gel. After 20 days, no differences were found between commercial, F+HMC, and F+Sn+HMC groups. Placebo did not differ from the control at any time points, and both groups presented the highest SL when compared to the other groups. For dentin, on the 5th day, F+Sn+HMC, F+HMC and commercial did not differ significantly, showing lower SL than the control and the placebo. On the 10th day, F+Sn+HMC and commercial presented the lowest SL compared to control and placebo. After 20 days, only the commercial gel showed lower SL than the control and placebo. Thus, the experimental F+Sn+HMC gel was able to control the progression of tooth erosion. |
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spelling |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosiondental erosionerosive tooth wearfluoridegelstannousThis study synthesized and tested experimental gels containing fluoride (F-) and stannous (Sn2+) ions for the control of dental erosion. Enamel and dentin polished specimens were eroded (1% citric acid solution, 10 min) and randomly allocated into 5 groups (n=10): Placebo-Hydroxypropyl Methylcellulose (HMC) gel; F+Sn+HMC-7,500 ppm F- / 15,000 ppm Sn2+; F+HMC-7,500 ppm F-; Commercial acidulated phosphate fluoride gel (12,300 ppm F-); and Control-no treatment. After treatment (applied for 60 s), specimens underwent an erosion-remineralization cycling (5 min in 0.3% citric acid solution, 60 min in artificial saliva, 4×/day, 20 days). Surface loss (SL, in µm) was determined after the 5th, 10th and 20th days of cycling (α=0.05). For enamel, after 5 and 10 days, F+Sn+HMC presented the lowest SL, which did not differ from the commercial gel. After 20 days, no differences were found between commercial, F+HMC, and F+Sn+HMC groups. Placebo did not differ from the control at any time points, and both groups presented the highest SL when compared to the other groups. For dentin, on the 5th day, F+Sn+HMC, F+HMC and commercial did not differ significantly, showing lower SL than the control and the placebo. On the 10th day, F+Sn+HMC and commercial presented the lowest SL compared to control and placebo. After 20 days, only the commercial gel showed lower SL than the control and placebo. Thus, the experimental F+Sn+HMC gel was able to control the progression of tooth erosion.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Restorative Dentistry University of São Paulo School of Dentistry, Av. Prof. Lineu Prestes 2227, SPDepartment of Restorative Dentistry at Institute of Science and Technology of São José dos Campos UNESP São Paulo State University, Av. Engenheiro Francisco José Longo 777, SPDepartment of Restorative Dentistry at Institute of Science and Technology of São José dos Campos UNESP São Paulo State University, Av. Engenheiro Francisco José Longo 777, SPFAPESP: 2020/07986-2Universidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Pereira, Laís Gatti de SouzaBezerra, Sávio José CardosoViana, Ítallo Emídio Lirade Lima, Leonardo CustódioBorges, Alessandra Bühler [UNESP]Scaramucci, Taís2023-03-01T21:08:44Z2023-03-01T21:08:44Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article54-61http://dx.doi.org/10.1590/0103-6440202204808Brazilian Dental Journal, v. 33, n. 4, p. 54-61, 2022.1806-47600103-6440http://hdl.handle.net/11449/24153710.1590/0103-64402022048082-s2.0-85136409033Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Dental Journalinfo:eu-repo/semantics/openAccess2023-03-01T21:08:44Zoai:repositorio.unesp.br:11449/241537Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:03:41.234489Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion |
title |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion |
spellingShingle |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion Pereira, Laís Gatti de Souza dental erosion erosive tooth wear fluoride gel stannous |
title_short |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion |
title_full |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion |
title_fullStr |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion |
title_full_unstemmed |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion |
title_sort |
Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion |
author |
Pereira, Laís Gatti de Souza |
author_facet |
Pereira, Laís Gatti de Souza Bezerra, Sávio José Cardoso Viana, Ítallo Emídio Lira de Lima, Leonardo Custódio Borges, Alessandra Bühler [UNESP] Scaramucci, Taís |
author_role |
author |
author2 |
Bezerra, Sávio José Cardoso Viana, Ítallo Emídio Lira de Lima, Leonardo Custódio Borges, Alessandra Bühler [UNESP] Scaramucci, Taís |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Pereira, Laís Gatti de Souza Bezerra, Sávio José Cardoso Viana, Ítallo Emídio Lira de Lima, Leonardo Custódio Borges, Alessandra Bühler [UNESP] Scaramucci, Taís |
dc.subject.por.fl_str_mv |
dental erosion erosive tooth wear fluoride gel stannous |
topic |
dental erosion erosive tooth wear fluoride gel stannous |
description |
This study synthesized and tested experimental gels containing fluoride (F-) and stannous (Sn2+) ions for the control of dental erosion. Enamel and dentin polished specimens were eroded (1% citric acid solution, 10 min) and randomly allocated into 5 groups (n=10): Placebo-Hydroxypropyl Methylcellulose (HMC) gel; F+Sn+HMC-7,500 ppm F- / 15,000 ppm Sn2+; F+HMC-7,500 ppm F-; Commercial acidulated phosphate fluoride gel (12,300 ppm F-); and Control-no treatment. After treatment (applied for 60 s), specimens underwent an erosion-remineralization cycling (5 min in 0.3% citric acid solution, 60 min in artificial saliva, 4×/day, 20 days). Surface loss (SL, in µm) was determined after the 5th, 10th and 20th days of cycling (α=0.05). For enamel, after 5 and 10 days, F+Sn+HMC presented the lowest SL, which did not differ from the commercial gel. After 20 days, no differences were found between commercial, F+HMC, and F+Sn+HMC groups. Placebo did not differ from the control at any time points, and both groups presented the highest SL when compared to the other groups. For dentin, on the 5th day, F+Sn+HMC, F+HMC and commercial did not differ significantly, showing lower SL than the control and the placebo. On the 10th day, F+Sn+HMC and commercial presented the lowest SL compared to control and placebo. After 20 days, only the commercial gel showed lower SL than the control and placebo. Thus, the experimental F+Sn+HMC gel was able to control the progression of tooth erosion. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T21:08:44Z 2023-03-01T21:08:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0103-6440202204808 Brazilian Dental Journal, v. 33, n. 4, p. 54-61, 2022. 1806-4760 0103-6440 http://hdl.handle.net/11449/241537 10.1590/0103-6440202204808 2-s2.0-85136409033 |
url |
http://dx.doi.org/10.1590/0103-6440202204808 http://hdl.handle.net/11449/241537 |
identifier_str_mv |
Brazilian Dental Journal, v. 33, n. 4, p. 54-61, 2022. 1806-4760 0103-6440 10.1590/0103-6440202204808 2-s2.0-85136409033 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Dental Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
54-61 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128602653327360 |