Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion

Detalhes bibliográficos
Autor(a) principal: Pereira, Laís Gatti de Souza
Data de Publicação: 2022
Outros Autores: Bezerra, Sávio José Cardoso, Viana, Ítallo Emídio Lira, de Lima, Leonardo Custódio, Borges, Alessandra Bühler [UNESP], Scaramucci, Taís
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/0103-6440202204808
http://hdl.handle.net/11449/241537
Resumo: This study synthesized and tested experimental gels containing fluoride (F-) and stannous (Sn2+) ions for the control of dental erosion. Enamel and dentin polished specimens were eroded (1% citric acid solution, 10 min) and randomly allocated into 5 groups (n=10): Placebo-Hydroxypropyl Methylcellulose (HMC) gel; F+Sn+HMC-7,500 ppm F- / 15,000 ppm Sn2+; F+HMC-7,500 ppm F-; Commercial acidulated phosphate fluoride gel (12,300 ppm F-); and Control-no treatment. After treatment (applied for 60 s), specimens underwent an erosion-remineralization cycling (5 min in 0.3% citric acid solution, 60 min in artificial saliva, 4×/day, 20 days). Surface loss (SL, in µm) was determined after the 5th, 10th and 20th days of cycling (α=0.05). For enamel, after 5 and 10 days, F+Sn+HMC presented the lowest SL, which did not differ from the commercial gel. After 20 days, no differences were found between commercial, F+HMC, and F+Sn+HMC groups. Placebo did not differ from the control at any time points, and both groups presented the highest SL when compared to the other groups. For dentin, on the 5th day, F+Sn+HMC, F+HMC and commercial did not differ significantly, showing lower SL than the control and the placebo. On the 10th day, F+Sn+HMC and commercial presented the lowest SL compared to control and placebo. After 20 days, only the commercial gel showed lower SL than the control and placebo. Thus, the experimental F+Sn+HMC gel was able to control the progression of tooth erosion.
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spelling Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosiondental erosionerosive tooth wearfluoridegelstannousThis study synthesized and tested experimental gels containing fluoride (F-) and stannous (Sn2+) ions for the control of dental erosion. Enamel and dentin polished specimens were eroded (1% citric acid solution, 10 min) and randomly allocated into 5 groups (n=10): Placebo-Hydroxypropyl Methylcellulose (HMC) gel; F+Sn+HMC-7,500 ppm F- / 15,000 ppm Sn2+; F+HMC-7,500 ppm F-; Commercial acidulated phosphate fluoride gel (12,300 ppm F-); and Control-no treatment. After treatment (applied for 60 s), specimens underwent an erosion-remineralization cycling (5 min in 0.3% citric acid solution, 60 min in artificial saliva, 4×/day, 20 days). Surface loss (SL, in µm) was determined after the 5th, 10th and 20th days of cycling (α=0.05). For enamel, after 5 and 10 days, F+Sn+HMC presented the lowest SL, which did not differ from the commercial gel. After 20 days, no differences were found between commercial, F+HMC, and F+Sn+HMC groups. Placebo did not differ from the control at any time points, and both groups presented the highest SL when compared to the other groups. For dentin, on the 5th day, F+Sn+HMC, F+HMC and commercial did not differ significantly, showing lower SL than the control and the placebo. On the 10th day, F+Sn+HMC and commercial presented the lowest SL compared to control and placebo. After 20 days, only the commercial gel showed lower SL than the control and placebo. Thus, the experimental F+Sn+HMC gel was able to control the progression of tooth erosion.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Restorative Dentistry University of São Paulo School of Dentistry, Av. Prof. Lineu Prestes 2227, SPDepartment of Restorative Dentistry at Institute of Science and Technology of São José dos Campos UNESP São Paulo State University, Av. Engenheiro Francisco José Longo 777, SPDepartment of Restorative Dentistry at Institute of Science and Technology of São José dos Campos UNESP São Paulo State University, Av. Engenheiro Francisco José Longo 777, SPFAPESP: 2020/07986-2Universidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Pereira, Laís Gatti de SouzaBezerra, Sávio José CardosoViana, Ítallo Emídio Lirade Lima, Leonardo CustódioBorges, Alessandra Bühler [UNESP]Scaramucci, Taís2023-03-01T21:08:44Z2023-03-01T21:08:44Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article54-61http://dx.doi.org/10.1590/0103-6440202204808Brazilian Dental Journal, v. 33, n. 4, p. 54-61, 2022.1806-47600103-6440http://hdl.handle.net/11449/24153710.1590/0103-64402022048082-s2.0-85136409033Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Dental Journalinfo:eu-repo/semantics/openAccess2023-03-01T21:08:44Zoai:repositorio.unesp.br:11449/241537Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:03:41.234489Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
title Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
spellingShingle Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
Pereira, Laís Gatti de Souza
dental erosion
erosive tooth wear
fluoride
gel
stannous
title_short Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
title_full Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
title_fullStr Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
title_full_unstemmed Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
title_sort Development of a sodium fluoride and stannous chloride-containing gel for treatment of dental erosion
author Pereira, Laís Gatti de Souza
author_facet Pereira, Laís Gatti de Souza
Bezerra, Sávio José Cardoso
Viana, Ítallo Emídio Lira
de Lima, Leonardo Custódio
Borges, Alessandra Bühler [UNESP]
Scaramucci, Taís
author_role author
author2 Bezerra, Sávio José Cardoso
Viana, Ítallo Emídio Lira
de Lima, Leonardo Custódio
Borges, Alessandra Bühler [UNESP]
Scaramucci, Taís
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Pereira, Laís Gatti de Souza
Bezerra, Sávio José Cardoso
Viana, Ítallo Emídio Lira
de Lima, Leonardo Custódio
Borges, Alessandra Bühler [UNESP]
Scaramucci, Taís
dc.subject.por.fl_str_mv dental erosion
erosive tooth wear
fluoride
gel
stannous
topic dental erosion
erosive tooth wear
fluoride
gel
stannous
description This study synthesized and tested experimental gels containing fluoride (F-) and stannous (Sn2+) ions for the control of dental erosion. Enamel and dentin polished specimens were eroded (1% citric acid solution, 10 min) and randomly allocated into 5 groups (n=10): Placebo-Hydroxypropyl Methylcellulose (HMC) gel; F+Sn+HMC-7,500 ppm F- / 15,000 ppm Sn2+; F+HMC-7,500 ppm F-; Commercial acidulated phosphate fluoride gel (12,300 ppm F-); and Control-no treatment. After treatment (applied for 60 s), specimens underwent an erosion-remineralization cycling (5 min in 0.3% citric acid solution, 60 min in artificial saliva, 4×/day, 20 days). Surface loss (SL, in µm) was determined after the 5th, 10th and 20th days of cycling (α=0.05). For enamel, after 5 and 10 days, F+Sn+HMC presented the lowest SL, which did not differ from the commercial gel. After 20 days, no differences were found between commercial, F+HMC, and F+Sn+HMC groups. Placebo did not differ from the control at any time points, and both groups presented the highest SL when compared to the other groups. For dentin, on the 5th day, F+Sn+HMC, F+HMC and commercial did not differ significantly, showing lower SL than the control and the placebo. On the 10th day, F+Sn+HMC and commercial presented the lowest SL compared to control and placebo. After 20 days, only the commercial gel showed lower SL than the control and placebo. Thus, the experimental F+Sn+HMC gel was able to control the progression of tooth erosion.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T21:08:44Z
2023-03-01T21:08:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0103-6440202204808
Brazilian Dental Journal, v. 33, n. 4, p. 54-61, 2022.
1806-4760
0103-6440
http://hdl.handle.net/11449/241537
10.1590/0103-6440202204808
2-s2.0-85136409033
url http://dx.doi.org/10.1590/0103-6440202204808
http://hdl.handle.net/11449/241537
identifier_str_mv Brazilian Dental Journal, v. 33, n. 4, p. 54-61, 2022.
1806-4760
0103-6440
10.1590/0103-6440202204808
2-s2.0-85136409033
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Dental Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 54-61
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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