Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ijms17020149 http://hdl.handle.net/11449/172466 |
Resumo: | The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smoothmuscle and/or intestinal transit. |
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Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activitiesAnti-inflammatoryAntidiarrhealCissus sicyoidesPGE2VitaceaeThe objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smoothmuscle and/or intestinal transit.Departamento de Fisiologia Instituto de Biociências Universidade Estadual Paulista—UNESPUnidade Integrada de Farmacologia e Gastroenterologia Universidade São FranciscoDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista—UNESPDepartamento de Ciências Biológicas Universidade Estadual Paulista—UNESPDepartamento de Botânica Instituto de Biociências Universidade Estadual Paulista—UNESPCampus Experimental do Litoral Paulista Universidade Estadual Paulista-UNESPDepartamento de Fisiologia Instituto de Biociências Universidade Estadual Paulista—UNESPDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista—UNESPDepartamento de Ciências Biológicas Universidade Estadual Paulista—UNESPDepartamento de Botânica Instituto de Biociências Universidade Estadual Paulista—UNESPCampus Experimental do Litoral Paulista Universidade Estadual Paulista-UNESPUniversidade Estadual Paulista (Unesp)Universidade São FranciscoBeserra, Fernando Pereira [UNESP]de Cássia Santos, RaquelPérico, Larissa Lucena [UNESP]Rodrigues, Vinicius Peixoto [UNESP]de Almeida Kiguti, Luiz Ricardo [UNESP]Saldanha, Luiz Leonardo [UNESP]Pupo, André Sampaio [UNESP]da Rocha, Lúcia Regina Machado [UNESP]Dokkedal, Anne Lígia [UNESP]Vilegas, Wagner [UNESP]Hiruma-Lima, Clélia Akiko [UNESP]2018-12-11T17:00:28Z2018-12-11T17:00:28Z2016-01-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.3390/ijms17020149International Journal of Molecular Sciences, v. 17, n. 2, 2016.1422-00671661-6596http://hdl.handle.net/11449/17246610.3390/ijms170201492-s2.0-849555753552-s2.0-84955575355.pdf38145049013868440000-0002-8645-3777Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Molecular Sciences1,260info:eu-repo/semantics/openAccess2023-12-24T06:15:23Zoai:repositorio.unesp.br:11449/172466Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-24T06:15:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities |
title |
Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities |
spellingShingle |
Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities Beserra, Fernando Pereira [UNESP] Anti-inflammatory Antidiarrheal Cissus sicyoides PGE2 Vitaceae |
title_short |
Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities |
title_full |
Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities |
title_fullStr |
Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities |
title_full_unstemmed |
Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities |
title_sort |
Cissus sicyoides: Pharmacological mechanisms involved in the anti-inflammatory and antidiarrheal activities |
author |
Beserra, Fernando Pereira [UNESP] |
author_facet |
Beserra, Fernando Pereira [UNESP] de Cássia Santos, Raquel Périco, Larissa Lucena [UNESP] Rodrigues, Vinicius Peixoto [UNESP] de Almeida Kiguti, Luiz Ricardo [UNESP] Saldanha, Luiz Leonardo [UNESP] Pupo, André Sampaio [UNESP] da Rocha, Lúcia Regina Machado [UNESP] Dokkedal, Anne Lígia [UNESP] Vilegas, Wagner [UNESP] Hiruma-Lima, Clélia Akiko [UNESP] |
author_role |
author |
author2 |
de Cássia Santos, Raquel Périco, Larissa Lucena [UNESP] Rodrigues, Vinicius Peixoto [UNESP] de Almeida Kiguti, Luiz Ricardo [UNESP] Saldanha, Luiz Leonardo [UNESP] Pupo, André Sampaio [UNESP] da Rocha, Lúcia Regina Machado [UNESP] Dokkedal, Anne Lígia [UNESP] Vilegas, Wagner [UNESP] Hiruma-Lima, Clélia Akiko [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade São Francisco |
dc.contributor.author.fl_str_mv |
Beserra, Fernando Pereira [UNESP] de Cássia Santos, Raquel Périco, Larissa Lucena [UNESP] Rodrigues, Vinicius Peixoto [UNESP] de Almeida Kiguti, Luiz Ricardo [UNESP] Saldanha, Luiz Leonardo [UNESP] Pupo, André Sampaio [UNESP] da Rocha, Lúcia Regina Machado [UNESP] Dokkedal, Anne Lígia [UNESP] Vilegas, Wagner [UNESP] Hiruma-Lima, Clélia Akiko [UNESP] |
dc.subject.por.fl_str_mv |
Anti-inflammatory Antidiarrheal Cissus sicyoides PGE2 Vitaceae |
topic |
Anti-inflammatory Antidiarrheal Cissus sicyoides PGE2 Vitaceae |
description |
The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smoothmuscle and/or intestinal transit. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-23 2018-12-11T17:00:28Z 2018-12-11T17:00:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ijms17020149 International Journal of Molecular Sciences, v. 17, n. 2, 2016. 1422-0067 1661-6596 http://hdl.handle.net/11449/172466 10.3390/ijms17020149 2-s2.0-84955575355 2-s2.0-84955575355.pdf 3814504901386844 0000-0002-8645-3777 |
url |
http://dx.doi.org/10.3390/ijms17020149 http://hdl.handle.net/11449/172466 |
identifier_str_mv |
International Journal of Molecular Sciences, v. 17, n. 2, 2016. 1422-0067 1661-6596 10.3390/ijms17020149 2-s2.0-84955575355 2-s2.0-84955575355.pdf 3814504901386844 0000-0002-8645-3777 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Molecular Sciences 1,260 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965389887635456 |