Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.marpolbul.2020.111493 http://hdl.handle.net/11449/199173 |
Resumo: | The consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity of three anticancer agents—Tamoxifen (TAM), Cisplatin (CisPt), and Cyclophosphamide (CP)—on the development of embryos of the sand-dollar Mellita quinquiesperforata. Adult individuals were collected in sandy beaches, and gametes were obtained. Freshly-fertilized eggs were exposed to increasing sets of concentrations of each compound, and the effective concentrations needed to cause a 50% effect in the organisms (EC50) were calculated. The three compounds were toxic, and their EC50 values were 16.78 ± 2.42 ng·L−1 (TAM), 27.20 ± 38.26 ng·L−1 (CisPt), and 101.82 ± 70.96 ng·L−1 (CP). There is no information on the environmental levels of these compounds in Brazil, but as they were already detected in ng·L−1 levels worldwide, it can be expected that these substances pose environmental risks to the marine biota. |
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Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforataChemotherapeuticsEchinodermsEcotoxicityMarine pollutionPharmaceuticalsThe consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity of three anticancer agents—Tamoxifen (TAM), Cisplatin (CisPt), and Cyclophosphamide (CP)—on the development of embryos of the sand-dollar Mellita quinquiesperforata. Adult individuals were collected in sandy beaches, and gametes were obtained. Freshly-fertilized eggs were exposed to increasing sets of concentrations of each compound, and the effective concentrations needed to cause a 50% effect in the organisms (EC50) were calculated. The three compounds were toxic, and their EC50 values were 16.78 ± 2.42 ng·L−1 (TAM), 27.20 ± 38.26 ng·L−1 (CisPt), and 101.82 ± 70.96 ng·L−1 (CP). There is no information on the environmental levels of these compounds in Brazil, but as they were already detected in ng·L−1 levels worldwide, it can be expected that these substances pose environmental risks to the marine biota.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Center of Studies on Aquatic Pollution and Ecoxicology (NEPEA) São Paulo State University - UNESPCentre for Marine and Environmental Research (CIMA) Universidade do Algarve, Campus de GambelasCenter of Studies on Aquatic Pollution and Ecoxicology (NEPEA) São Paulo State University - UNESPFAPESP: 18/19123-9CNPq: 202360/2014-8CNPq: 308533/2018-6CNPq: 311609/2014-7Universidade Estadual Paulista (Unesp)Universidade do AlgarveMello, Luiza Costa [UNESP]da Fonseca, Taina Garcia [UNESP]Denis Moledode de Souza, Abessa [UNESP]2020-12-12T01:32:40Z2020-12-12T01:32:40Z2020-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.marpolbul.2020.111493Marine Pollution Bulletin, v. 159.1879-33630025-326Xhttp://hdl.handle.net/11449/19917310.1016/j.marpolbul.2020.1114932-s2.0-85088651000Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMarine Pollution Bulletininfo:eu-repo/semantics/openAccess2021-10-23T04:23:59Zoai:repositorio.unesp.br:11449/199173Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:58:44.730920Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata |
title |
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata |
spellingShingle |
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata Mello, Luiza Costa [UNESP] Chemotherapeutics Echinoderms Ecotoxicity Marine pollution Pharmaceuticals |
title_short |
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata |
title_full |
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata |
title_fullStr |
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata |
title_full_unstemmed |
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata |
title_sort |
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata |
author |
Mello, Luiza Costa [UNESP] |
author_facet |
Mello, Luiza Costa [UNESP] da Fonseca, Taina Garcia [UNESP] Denis Moledode de Souza, Abessa [UNESP] |
author_role |
author |
author2 |
da Fonseca, Taina Garcia [UNESP] Denis Moledode de Souza, Abessa [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade do Algarve |
dc.contributor.author.fl_str_mv |
Mello, Luiza Costa [UNESP] da Fonseca, Taina Garcia [UNESP] Denis Moledode de Souza, Abessa [UNESP] |
dc.subject.por.fl_str_mv |
Chemotherapeutics Echinoderms Ecotoxicity Marine pollution Pharmaceuticals |
topic |
Chemotherapeutics Echinoderms Ecotoxicity Marine pollution Pharmaceuticals |
description |
The consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity of three anticancer agents—Tamoxifen (TAM), Cisplatin (CisPt), and Cyclophosphamide (CP)—on the development of embryos of the sand-dollar Mellita quinquiesperforata. Adult individuals were collected in sandy beaches, and gametes were obtained. Freshly-fertilized eggs were exposed to increasing sets of concentrations of each compound, and the effective concentrations needed to cause a 50% effect in the organisms (EC50) were calculated. The three compounds were toxic, and their EC50 values were 16.78 ± 2.42 ng·L−1 (TAM), 27.20 ± 38.26 ng·L−1 (CisPt), and 101.82 ± 70.96 ng·L−1 (CP). There is no information on the environmental levels of these compounds in Brazil, but as they were already detected in ng·L−1 levels worldwide, it can be expected that these substances pose environmental risks to the marine biota. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:32:40Z 2020-12-12T01:32:40Z 2020-10-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.marpolbul.2020.111493 Marine Pollution Bulletin, v. 159. 1879-3363 0025-326X http://hdl.handle.net/11449/199173 10.1016/j.marpolbul.2020.111493 2-s2.0-85088651000 |
url |
http://dx.doi.org/10.1016/j.marpolbul.2020.111493 http://hdl.handle.net/11449/199173 |
identifier_str_mv |
Marine Pollution Bulletin, v. 159. 1879-3363 0025-326X 10.1016/j.marpolbul.2020.111493 2-s2.0-85088651000 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marine Pollution Bulletin |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129380386340864 |