Efeitos da administração subaracnoidea em punção única, de cetamina S(+) a 5%, sem conservantes, sobre a medula espinal e as meninges de coelhos

• Autor(a) principal: Lima Filho, José Admirço [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/123812; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/12-05-2015/000823248.pdf
• topic: Anestesicos - Efeito fisiologico; Meninges; Injeções; Medicamentos - Administração

Background: Pain relief is one of the tasks of the anesthesiologist . Among the drugs used for this purpose include the ketamine (blocker of N-methyl D aspartate receptor). It can be administered by various routes among which spinal and epidural. Results of clinical and experimental studies have shown that ketamine S (+) was effective in relieving postoperative pain when introduced into the epidural space. Almost nothing is known about his administration in the subarachnoid space. Neurological lesions were described in the medullary tissue of humans and animals when using ketamine S(+) 5% preservative free, the subarachnoid space, the same lesions have been reported in animals with the drug devoid of preservatives. Objective: To evaluate the effects of ketamine S (+) 5% preservative free, administered by the intrathecal route in single puncture , determines on the spinal cord and meninges of rabbits. Method: Twenty young adult female rabbits, weighing 3500-5000 g with entre34 spine length and 38 cm were divided by lot into two groups (G ): 0.9% saline G1 , G2 ketamine S (+) 5% by volume of 5μg per cm column (1,8 μl). After intravenous anesthesia with ketamine and xylazine spinal puncture was performed in S1 - S2 ultrasound guided and injected a random solution. The animals remained in captivity for 21 days under medical observation and were sacrificed by decapitation and removal of the lumbosacral portion of the spinal cord for histologic examination [hematoxylin and eosin (HE)] and immunohistochemistry for glial fibrillary acidic protein (GFAP). Results: No animal showed histological lesions of nerve tissue (roots and cord) and meninges. Conclusions: In this experimental model in rabbits ketamine S (+) 5% preservative free triggered no neurological or histological lesions in the spinal cord and meninges