A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

Detalhes bibliográficos
Autor(a) principal: Vita-Marques, Aline Maria de
Data de Publicação: 2008
Outros Autores: Lira, Simone P., Berlinck, Roberto G. S., Seleghim, Mirna H. R., Sponchiado, Sandra R. P. [UNESP], Tauk-Tornisielo, Sâmia M. [UNESP], Barata, Margarida, Pessoa, Claudia, Moraes, Manoel O. de, Cavalcanti, Bruno Coêlho, Nascimento, Gislene G. F., Souza, Ana O. de, Galetti, Fabio C. S., Silva, Célio L., Silva, Marcio, Pimenta, Eli F., Thiemann, Otavio, Passarini, Michel R. Z., Sette, Lara D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-40422008000500030
http://hdl.handle.net/11449/25237
Resumo: Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.
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spelling A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felinamarine-derived fungiscreeningBeauveria felinaExtracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.NIH (National Institutes of Health)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade de São Paulo Instituto de Química de São CarlosUniversidade Federal de São Carlos (UFSCar) Departamento de Ecologia e Biologia EvolutivaUniversidade Estadual Paulista Departamento de Bioquímica e Tecnologia QuímicaUniversidade Estadual Paulista Centro de Estudos AmbientaisFaculdade de Ciências de Lisboa Centro de Biologia Ambiental Departamento de Biologia Vegetal (Microbiologia)Universidade Federal do Ceará (UFC) Departamento de Fisiologia e FarmacologiaUniversidade Metodista de Piracicaba Faculdade de Ciências da SaúdeInstituto ButantanUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Bioquímica e ImunologiaUniversidade de São Paulo Instituto de Física de São CarlosUniversidade Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas Divisão de Recursos MicrobianosUniversidade Estadual Paulista Departamento de Bioquímica e Tecnologia QuímicaUniversidade Estadual Paulista Centro de Estudos AmbientaisSociedade Brasileira de QuímicaUniversidade de São Paulo (USP)Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)Faculdade de Ciências de LisboaUniversidade Federal do Ceará (UFC)Universidade Metodista de PiracicabaInstituto ButantanUniversidade Estadual de Campinas (UNICAMP)Vita-Marques, Aline Maria deLira, Simone P.Berlinck, Roberto G. S.Seleghim, Mirna H. R.Sponchiado, Sandra R. P. [UNESP]Tauk-Tornisielo, Sâmia M. [UNESP]Barata, MargaridaPessoa, ClaudiaMoraes, Manoel O. deCavalcanti, Bruno CoêlhoNascimento, Gislene G. F.Souza, Ana O. deGaletti, Fabio C. S.Silva, Célio L.Silva, MarcioPimenta, Eli F.Thiemann, OtavioPassarini, Michel R. Z.Sette, Lara D.2014-05-20T14:17:29Z2014-05-20T14:17:29Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1099-1103application/pdfhttp://dx.doi.org/10.1590/S0100-40422008000500030Química Nova. Sociedade Brasileira de Química, v. 31, n. 5, p. 1099-1103, 2008.0100-4042http://hdl.handle.net/11449/2523710.1590/S0100-40422008000500030S0100-40422008000500030WOS:000259122200030S0100-40422008000500030.pdf83448237606338090000-0002-3250-8891SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengQuímica Nova0.6460,255info:eu-repo/semantics/openAccess2024-04-10T19:22:34Zoai:repositorio.unesp.br:11449/25237Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:01:22.753954Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
spellingShingle A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
Vita-Marques, Aline Maria de
marine-derived fungi
screening
Beauveria felina
title_short A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_full A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_fullStr A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_full_unstemmed A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
title_sort A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina
author Vita-Marques, Aline Maria de
author_facet Vita-Marques, Aline Maria de
Lira, Simone P.
Berlinck, Roberto G. S.
Seleghim, Mirna H. R.
Sponchiado, Sandra R. P. [UNESP]
Tauk-Tornisielo, Sâmia M. [UNESP]
Barata, Margarida
Pessoa, Claudia
Moraes, Manoel O. de
Cavalcanti, Bruno Coêlho
Nascimento, Gislene G. F.
Souza, Ana O. de
Galetti, Fabio C. S.
Silva, Célio L.
Silva, Marcio
Pimenta, Eli F.
Thiemann, Otavio
Passarini, Michel R. Z.
Sette, Lara D.
author_role author
author2 Lira, Simone P.
Berlinck, Roberto G. S.
Seleghim, Mirna H. R.
Sponchiado, Sandra R. P. [UNESP]
Tauk-Tornisielo, Sâmia M. [UNESP]
Barata, Margarida
Pessoa, Claudia
Moraes, Manoel O. de
Cavalcanti, Bruno Coêlho
Nascimento, Gislene G. F.
Souza, Ana O. de
Galetti, Fabio C. S.
Silva, Célio L.
Silva, Marcio
Pimenta, Eli F.
Thiemann, Otavio
Passarini, Michel R. Z.
Sette, Lara D.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Federal de São Carlos (UFSCar)
Universidade Estadual Paulista (Unesp)
Faculdade de Ciências de Lisboa
Universidade Federal do Ceará (UFC)
Universidade Metodista de Piracicaba
Instituto Butantan
Universidade Estadual de Campinas (UNICAMP)
dc.contributor.author.fl_str_mv Vita-Marques, Aline Maria de
Lira, Simone P.
Berlinck, Roberto G. S.
Seleghim, Mirna H. R.
Sponchiado, Sandra R. P. [UNESP]
Tauk-Tornisielo, Sâmia M. [UNESP]
Barata, Margarida
Pessoa, Claudia
Moraes, Manoel O. de
Cavalcanti, Bruno Coêlho
Nascimento, Gislene G. F.
Souza, Ana O. de
Galetti, Fabio C. S.
Silva, Célio L.
Silva, Marcio
Pimenta, Eli F.
Thiemann, Otavio
Passarini, Michel R. Z.
Sette, Lara D.
dc.subject.por.fl_str_mv marine-derived fungi
screening
Beauveria felina
topic marine-derived fungi
screening
Beauveria felina
description Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
2014-05-20T14:17:29Z
2014-05-20T14:17:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40422008000500030
Química Nova. Sociedade Brasileira de Química, v. 31, n. 5, p. 1099-1103, 2008.
0100-4042
http://hdl.handle.net/11449/25237
10.1590/S0100-40422008000500030
S0100-40422008000500030
WOS:000259122200030
S0100-40422008000500030.pdf
8344823760633809
0000-0002-3250-8891
url http://dx.doi.org/10.1590/S0100-40422008000500030
http://hdl.handle.net/11449/25237
identifier_str_mv Química Nova. Sociedade Brasileira de Química, v. 31, n. 5, p. 1099-1103, 2008.
0100-4042
10.1590/S0100-40422008000500030
S0100-40422008000500030
WOS:000259122200030
S0100-40422008000500030.pdf
8344823760633809
0000-0002-3250-8891
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Química Nova
0.646
0,255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1099-1103
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129573507825664

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