Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-7757-2021-0583 http://hdl.handle.net/11449/234305 |
Resumo: | OBJECTIVE: This study assessed the efficacy of two adjunct therapies (antibiotic and probiotic) for periodontal treatment based on clinical and immunological parameters in patients with Stage II and III Grade B periodontitis. METHODOLOGY: 45 patients were randomly allocated into three groups: control group (CG); antibiotic group (GAtb), in which 500 mg amoxicillin + 400 mg metronidazole were used; and probiotic group (GProb), for which Lactobacillus reuteri was used. Patients received medications after undergoing periodontal debridement. Clinical and immunological parameters were assessed at baseline, 30 days, and 90 days. RESULTS: All therapies reduced bleeding on probing (BoP) in the evaluated periods, and the GAtb had a greater reduction at 90 days (p=0.03). The GProb group showed better results for plaque index (PI) and gingival recession (GR) compared to the GAtb at 90 days (p=0.0014; p=0.006). The area of inflammation (PISA Index) significantly decreased in all therapies in the evaluated periods. Therapies had no significant differences regarding moderate pockets. The GAtb had a greater reduction in probing depth (PD) for deep pockets (p=0.03) at 90 days and in the number of deep pocket sites at 30 days (p=0.04). The occurrence of adverse effects was commonly reported in the GAtb as a percentage per patient. The GAtb had a significant reduction in the concentration of interleukins IL-1β and IL-8 and an increase in IL-10 and TNF-α. The CG had a reduction in IL-6 and IL-1 β, whereas in the GProb there was no difference. CONCLUSION: After three months, none of the adjuvant therapies provided any additional benefit for subgingival instrumentation. |
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Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical studyOBJECTIVE: This study assessed the efficacy of two adjunct therapies (antibiotic and probiotic) for periodontal treatment based on clinical and immunological parameters in patients with Stage II and III Grade B periodontitis. METHODOLOGY: 45 patients were randomly allocated into three groups: control group (CG); antibiotic group (GAtb), in which 500 mg amoxicillin + 400 mg metronidazole were used; and probiotic group (GProb), for which Lactobacillus reuteri was used. Patients received medications after undergoing periodontal debridement. Clinical and immunological parameters were assessed at baseline, 30 days, and 90 days. RESULTS: All therapies reduced bleeding on probing (BoP) in the evaluated periods, and the GAtb had a greater reduction at 90 days (p=0.03). The GProb group showed better results for plaque index (PI) and gingival recession (GR) compared to the GAtb at 90 days (p=0.0014; p=0.006). The area of inflammation (PISA Index) significantly decreased in all therapies in the evaluated periods. Therapies had no significant differences regarding moderate pockets. The GAtb had a greater reduction in probing depth (PD) for deep pockets (p=0.03) at 90 days and in the number of deep pocket sites at 30 days (p=0.04). The occurrence of adverse effects was commonly reported in the GAtb as a percentage per patient. The GAtb had a significant reduction in the concentration of interleukins IL-1β and IL-8 and an increase in IL-10 and TNF-α. The CG had a reduction in IL-6 and IL-1 β, whereas in the GProb there was no difference. CONCLUSION: After three months, none of the adjuvant therapies provided any additional benefit for subgingival instrumentation.Universidade Estadual Paulista (UNESP) Faculdade de Odontologia Programa de Biopatologia Bucal Área de PeriodontiaUniversidade de São Paulo (USP) Faculdade de Odontologia Divisão de Periodontia Departamento de EstomatologiaUniversidade Estadual Paulista (UNESP) Instituto de Ciências e Tecnologia Departamento de Diagnóstico e Cirurgia Área de PeriodontiaUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia Programa de Biopatologia Bucal Área de PeriodontiaUniversidade Estadual Paulista (UNESP) Instituto de Ciências e Tecnologia Departamento de Diagnóstico e Cirurgia Área de PeriodontiaUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Ramos, Tatiane Caroline de Souza [UNESP]Boas, Mariéllen Longo Vilas [UNESP]Nunes, Camilla Magnoni Moretto [UNESP]Ferreira, Camila Lopes [UNESP]Pannuti, Cláudio MendesSantamaria, Mauro Pedrine [UNESP]Jardini, Maria Aparecida Neves [UNESP]2022-05-01T15:46:18Z2022-05-01T15:46:18Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlee20210583http://dx.doi.org/10.1590/1678-7757-2021-0583Journal of applied oral science : revista FOB, v. 30, p. e20210583-.1678-7765http://hdl.handle.net/11449/23430510.1590/1678-7757-2021-05832-s2.0-85126907410Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of applied oral science : revista FOBinfo:eu-repo/semantics/openAccess2022-05-01T15:46:18Zoai:repositorio.unesp.br:11449/234305Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-01T15:46:18Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study |
title |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study |
spellingShingle |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study Ramos, Tatiane Caroline de Souza [UNESP] |
title_short |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study |
title_full |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study |
title_fullStr |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study |
title_full_unstemmed |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study |
title_sort |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study |
author |
Ramos, Tatiane Caroline de Souza [UNESP] |
author_facet |
Ramos, Tatiane Caroline de Souza [UNESP] Boas, Mariéllen Longo Vilas [UNESP] Nunes, Camilla Magnoni Moretto [UNESP] Ferreira, Camila Lopes [UNESP] Pannuti, Cláudio Mendes Santamaria, Mauro Pedrine [UNESP] Jardini, Maria Aparecida Neves [UNESP] |
author_role |
author |
author2 |
Boas, Mariéllen Longo Vilas [UNESP] Nunes, Camilla Magnoni Moretto [UNESP] Ferreira, Camila Lopes [UNESP] Pannuti, Cláudio Mendes Santamaria, Mauro Pedrine [UNESP] Jardini, Maria Aparecida Neves [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Ramos, Tatiane Caroline de Souza [UNESP] Boas, Mariéllen Longo Vilas [UNESP] Nunes, Camilla Magnoni Moretto [UNESP] Ferreira, Camila Lopes [UNESP] Pannuti, Cláudio Mendes Santamaria, Mauro Pedrine [UNESP] Jardini, Maria Aparecida Neves [UNESP] |
description |
OBJECTIVE: This study assessed the efficacy of two adjunct therapies (antibiotic and probiotic) for periodontal treatment based on clinical and immunological parameters in patients with Stage II and III Grade B periodontitis. METHODOLOGY: 45 patients were randomly allocated into three groups: control group (CG); antibiotic group (GAtb), in which 500 mg amoxicillin + 400 mg metronidazole were used; and probiotic group (GProb), for which Lactobacillus reuteri was used. Patients received medications after undergoing periodontal debridement. Clinical and immunological parameters were assessed at baseline, 30 days, and 90 days. RESULTS: All therapies reduced bleeding on probing (BoP) in the evaluated periods, and the GAtb had a greater reduction at 90 days (p=0.03). The GProb group showed better results for plaque index (PI) and gingival recession (GR) compared to the GAtb at 90 days (p=0.0014; p=0.006). The area of inflammation (PISA Index) significantly decreased in all therapies in the evaluated periods. Therapies had no significant differences regarding moderate pockets. The GAtb had a greater reduction in probing depth (PD) for deep pockets (p=0.03) at 90 days and in the number of deep pocket sites at 30 days (p=0.04). The occurrence of adverse effects was commonly reported in the GAtb as a percentage per patient. The GAtb had a significant reduction in the concentration of interleukins IL-1β and IL-8 and an increase in IL-10 and TNF-α. The CG had a reduction in IL-6 and IL-1 β, whereas in the GProb there was no difference. CONCLUSION: After three months, none of the adjuvant therapies provided any additional benefit for subgingival instrumentation. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T15:46:18Z 2022-05-01T15:46:18Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-7757-2021-0583 Journal of applied oral science : revista FOB, v. 30, p. e20210583-. 1678-7765 http://hdl.handle.net/11449/234305 10.1590/1678-7757-2021-0583 2-s2.0-85126907410 |
url |
http://dx.doi.org/10.1590/1678-7757-2021-0583 http://hdl.handle.net/11449/234305 |
identifier_str_mv |
Journal of applied oral science : revista FOB, v. 30, p. e20210583-. 1678-7765 10.1590/1678-7757-2021-0583 2-s2.0-85126907410 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of applied oral science : revista FOB |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
e20210583 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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