Construction of ethics in clinical research - Clinical trials registration
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992007000400004 http://hdl.handle.net/11449/70078 |
Resumo: | Scientific development that has been achieved through decades finds in clinical research a great possibility of translating findings to human health application. Evidence given by clinical trials allows everyone to have access to the best health services. However, the millionaire world of pharmaceutical industries has stained clinical research with doubt and improbability. Study results (fruits of controlled clinical trials) and scientific publications (selective, manipulated and with wrong conclusions) led to an inappropriate clinical practice, favoring the involved economic aspect. In 2005, the International Committee of Medical Journal Editors (ICMJE), supported by the World Association of Medical Editors, started demanding as a requisite for publication that all clinical trials be registered at the database ClinicalTrials.gov. In 2006, the World Health Organization (WHO) created the International Clinical Trial Registry Platform (ICTRP), which gathers several registry centers from all over the world, and required that all researchers and pharmaceutical industries register clinical trials. Such obligatory registration has progressed and will extend to all scientific journals indexed in all worldwide databases. Registration of clinical trials means another step of clinical research towards transparency, ethics and impartiality, resulting in real evidence to the forthcoming changes in clinical practice as well as in the health situation. |
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Construction of ethics in clinical research - Clinical trials registrationBiomedical researchClinical trialsDrug information servicesEthicsWorld health organizationScientific development that has been achieved through decades finds in clinical research a great possibility of translating findings to human health application. Evidence given by clinical trials allows everyone to have access to the best health services. However, the millionaire world of pharmaceutical industries has stained clinical research with doubt and improbability. Study results (fruits of controlled clinical trials) and scientific publications (selective, manipulated and with wrong conclusions) led to an inappropriate clinical practice, favoring the involved economic aspect. In 2005, the International Committee of Medical Journal Editors (ICMJE), supported by the World Association of Medical Editors, started demanding as a requisite for publication that all clinical trials be registered at the database ClinicalTrials.gov. In 2006, the World Health Organization (WHO) created the International Clinical Trial Registry Platform (ICTRP), which gathers several registry centers from all over the world, and required that all researchers and pharmaceutical industries register clinical trials. Such obligatory registration has progressed and will extend to all scientific journals indexed in all worldwide databases. Registration of clinical trials means another step of clinical research towards transparency, ethics and impartiality, resulting in real evidence to the forthcoming changes in clinical practice as well as in the health situation.Department of Clinical Medicine Botucatu Medical School São Paulo State University, Botucatu, São Paulo StateClinical Research Unity (UPECLIN) Clinical Hospital Botucatu Medical School, Botucatu, São Paulo StateUPECLIN - Unidade de Pesquisa Clínica Hospital Das Clínicas Campus de Botucatu, 18618-970, Botucatu, SPDepartment of Clinical Medicine Botucatu Medical School São Paulo State University, Botucatu, São Paulo StateClinical Research Unity (UPECLIN) Clinical Hospital Botucatu Medical School, Botucatu, São Paulo StateUniversidade Estadual Paulista (Unesp)Caramori, Carlos Antonio [UNESP]2014-05-27T11:22:41Z2014-05-27T11:22:41Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article729-736application/pdfhttp://dx.doi.org/10.1590/S1678-91992007000400004Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 729-736, 2007.1678-9199http://hdl.handle.net/11449/7007810.1590/S1678-91992007000400004S1678-91992007000400004WOS:0002513252000042-s2.0-383491210012-s2.0-38349121001.pdf5518720125698768Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2024-08-14T17:22:36Zoai:repositorio.unesp.br:11449/70078Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Construction of ethics in clinical research - Clinical trials registration |
title |
Construction of ethics in clinical research - Clinical trials registration |
spellingShingle |
Construction of ethics in clinical research - Clinical trials registration Caramori, Carlos Antonio [UNESP] Biomedical research Clinical trials Drug information services Ethics World health organization |
title_short |
Construction of ethics in clinical research - Clinical trials registration |
title_full |
Construction of ethics in clinical research - Clinical trials registration |
title_fullStr |
Construction of ethics in clinical research - Clinical trials registration |
title_full_unstemmed |
Construction of ethics in clinical research - Clinical trials registration |
title_sort |
Construction of ethics in clinical research - Clinical trials registration |
author |
Caramori, Carlos Antonio [UNESP] |
author_facet |
Caramori, Carlos Antonio [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Caramori, Carlos Antonio [UNESP] |
dc.subject.por.fl_str_mv |
Biomedical research Clinical trials Drug information services Ethics World health organization |
topic |
Biomedical research Clinical trials Drug information services Ethics World health organization |
description |
Scientific development that has been achieved through decades finds in clinical research a great possibility of translating findings to human health application. Evidence given by clinical trials allows everyone to have access to the best health services. However, the millionaire world of pharmaceutical industries has stained clinical research with doubt and improbability. Study results (fruits of controlled clinical trials) and scientific publications (selective, manipulated and with wrong conclusions) led to an inappropriate clinical practice, favoring the involved economic aspect. In 2005, the International Committee of Medical Journal Editors (ICMJE), supported by the World Association of Medical Editors, started demanding as a requisite for publication that all clinical trials be registered at the database ClinicalTrials.gov. In 2006, the World Health Organization (WHO) created the International Clinical Trial Registry Platform (ICTRP), which gathers several registry centers from all over the world, and required that all researchers and pharmaceutical industries register clinical trials. Such obligatory registration has progressed and will extend to all scientific journals indexed in all worldwide databases. Registration of clinical trials means another step of clinical research towards transparency, ethics and impartiality, resulting in real evidence to the forthcoming changes in clinical practice as well as in the health situation. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 2014-05-27T11:22:41Z 2014-05-27T11:22:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992007000400004 Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 729-736, 2007. 1678-9199 http://hdl.handle.net/11449/70078 10.1590/S1678-91992007000400004 S1678-91992007000400004 WOS:000251325200004 2-s2.0-38349121001 2-s2.0-38349121001.pdf 5518720125698768 |
url |
http://dx.doi.org/10.1590/S1678-91992007000400004 http://hdl.handle.net/11449/70078 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 729-736, 2007. 1678-9199 10.1590/S1678-91992007000400004 S1678-91992007000400004 WOS:000251325200004 2-s2.0-38349121001 2-s2.0-38349121001.pdf 5518720125698768 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases 1.782 0,573 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
729-736 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128128117112832 |