Central Odontogenic Fibroma with the Presence of Large Fibroblasts of Varying Morphology

• Autor(a) principal: Costa, Victor [UNESP]
• Data de Publicação: 2020
• Outros Autores: Anbinder, Ana Lia [UNESP], Herrera, Fernanda [UNESP], Rodrigues, Nayara [UNESP], Cavalcante, Ana Sueli Rodrigues [UNESP], Kaminagakura, Estela [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1007/s12105-020-01207-2
• Texto Completo: http://dx.doi.org/10.1007/s12105-020-01207-2; http://hdl.handle.net/11449/202060
• topic: Desmoplasia; Large fibroblast; Odontogenic tumor

A patient with an odontogenic fibroma (OF) with the presence of fibroblasts of varying morphology is presented, and the main microscopic differential diagnosis is discussed. Case report: a 51-year-old man complained of a swelling in the anterior region of the mandible. The panoramic radiograph showed a radiolucent, well-defined multilocular image, with displacement of the roots of the left mandibular incisors and canine. A cone beam computed tomography examination revealed a hypodense image, with delicate bone spicules inside, divergence of the tooth roots and destruction of the buccal cortical bone. Under the differential diagnosis of a desmoplastic ameloblastoma or a squamous odontogenic tumor, an incisional biopsy was made. Microscopically, deeply collagenized tissue with scarce odontogenic epithelium islands, large fibroblasts of varying morphology and calcified material was observed. A diagnosis of OF was made. Surgical removal was carried out, and the specimen was examined. Identical aspects were found, and the immunohistochemical reaction for pan-cytokeratin was carried out to identify the odontogenic epithelial cells. The definitive diagnosis of OF was confirmed, and we emphasize the importance of the correlation of all characteristics for a definitive diagnosis.