IMMUNOPATHOLOGICAL FINDINGS IN A CAT WITH AURICULAR CHONDRITIS

• Autor(a) principal: Wilson, Tais Meziara
• Data de Publicação: 2019
• Outros Autores: Machado, Mizael, Ribeiro De Sousa, Davi Emanuel, Brauna, Taina, Neto, Rafael Torres, Laufer-Amorim, Renee [UNESP], Juan Szabo, Matias Pablo, De Castro, Marcio Botelho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1556/004.2019.009
• Texto Completo: http://dx.doi.org/10.1556/004.2019.009; http://hdl.handle.net/11449/186354
• topic: Feline; macrophage; immunohistochemistry; immunopathogenesis; chondritis

At clinical examination, a 5-year-old male domestic short-haired cat exhibited painful swelling and erythema of the pinnae of both ears. Microscopically, the lesions on both pinnae were composed of diffuse granulomatous chondritis with degeneration and necrosis of the pinnal cartilage. Numerous mast cells were also observed within and surrounding the inflammatory lesion. Immunohistochemistry showed a mixed inflammatory infiltrate characterised by the predominance of macrophages (CD68+, MAC 387+ and Lysozyme+), T lymphocytes (CD3+), some B lymphocytes (CD79 alpha+) and neutrophils. Immunopathological characterisation of the lesion showed a granulomatous inflammation profile and suggests that the morphological changes and immunopathogenesis of auricular chondritis in cats presents a similarity with relapsing polychondritis in humans.