Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-3-artigo-04.pdf http://hdl.handle.net/11449/141062 |
Resumo: | Objectives: Analyse the expression of galectin-3 and distribution of matrix proteins, laminin, fibronectin and collagen IV, in 30 paraffinated samples of nasopharynx carcinoma (NFC); and correlate the to clinicopathological characteristics, as tumor aggressiveness and survival of individuals. Study design: retrospective clinical study. Methods: The analyses were performed by immunohistochemistry study the expression of the matrix protein and galectin-3 in 30 tissue samples of 26 patients diagnosed with nasopharyngeal carcinoma. Results: The analysis showed that the patients mean age was 48 years-old, with the age peak prevalence was from 60 to 69 years-old, with male predominance of 2:1. The undifferentiated non-keratinized squamous cell carcinoma was predominant in 23 samples (79%), differentiated non-keratinized squamous cell carcinoma was found in 4 samples (13.3%) and keratinized squamous cell carcinoma was found in 3 samples (10%). The laminin expression, which is normally restricted to the vessel walls and lamina propria, was increased in the neoplasic cell matrix in 23 samples (76.7%). Fibronectin was positive in 23 samples (43%). Galectin-3 was observed in 21 samples (70%). Seven cases showed positive correlation between all three proteins. Eleven cases presented positive correlation of laminin and galectin-3 immunoexpression. Conclusions: Fibronectin presence seems to reduce the chance of tumor recurrence and also, increase the survival rate, differently from laminin and galectin-3. |
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Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matrizNasopharynx Carcinoma: Analyse of the prognostic importance of the immunoexpression of galactin-3 and matrix proteinsNasopharyngeal neoplasmsGalectin 3FibronectinsLamininNeoplasias nasofaríngeasGalectina 3FibronectinasLamininaObjectives: Analyse the expression of galectin-3 and distribution of matrix proteins, laminin, fibronectin and collagen IV, in 30 paraffinated samples of nasopharynx carcinoma (NFC); and correlate the to clinicopathological characteristics, as tumor aggressiveness and survival of individuals. Study design: retrospective clinical study. Methods: The analyses were performed by immunohistochemistry study the expression of the matrix protein and galectin-3 in 30 tissue samples of 26 patients diagnosed with nasopharyngeal carcinoma. Results: The analysis showed that the patients mean age was 48 years-old, with the age peak prevalence was from 60 to 69 years-old, with male predominance of 2:1. The undifferentiated non-keratinized squamous cell carcinoma was predominant in 23 samples (79%), differentiated non-keratinized squamous cell carcinoma was found in 4 samples (13.3%) and keratinized squamous cell carcinoma was found in 3 samples (10%). The laminin expression, which is normally restricted to the vessel walls and lamina propria, was increased in the neoplasic cell matrix in 23 samples (76.7%). Fibronectin was positive in 23 samples (43%). Galectin-3 was observed in 21 samples (70%). Seven cases showed positive correlation between all three proteins. Eleven cases presented positive correlation of laminin and galectin-3 immunoexpression. Conclusions: Fibronectin presence seems to reduce the chance of tumor recurrence and also, increase the survival rate, differently from laminin and galectin-3.Objetivo: Estudar a expressão da Galectina-3 e a distribuição das proteínas de matriz, laminina, fibronectina e colágeno IV, em 30 amostras teciduais de carcinoma de nasofaringe (CNF) e correlacionar com as características clinicopatológicas, agressividade tumoral e sobrevida dos indivíduos. Forma de estudo: clínico retrospectivo. Material: Foram estudadas por método imunohistoquímico a expressão das proteínas de matriz e a galectina-3 de 30 amostras teciduais de 26 pacientes com diagnóstico de Carcinoma de Nasofaringe. Resultados: A análise mostrou que a media etária foi de 48 anos, com o pico de prevalência entre 60 a 69 anos, e predominância do sexo masculino de 2:1. O Carcinoma Escamoso Não Ceratinizante Indiferenciado foi mais comum em 23 amostras (76,7%), o Carcinoma Escamoso Não Ceratinizante Diferenciado em 4 amostras (13.3%) e Carcinoma Escamoso Ceratinizante em 3 amostras (10,0%). A expressão da laminina que normalmente é restrita à parede dos vasos e na lâmina própria, estava muito aumentada na matriz das células neoplásicas em 23 amostras (76,7%); a fibronectina foi positiva em 13 amostras (43%) e a galectina-3 foi positiva em 21 amostras (70%). Tivemos correlação positiva da laminina, fibronectina e galectina-3 em 7 amostras (23,3%) e entre laminina e galectina-3 em 11amostras (36,6%). Conclusão: A expressão positiva da Galectina-3 e da laminina não mostrou correlação significativa quanto à agressividade tumoral e a sobrevida dos pacientes, enquanto a expressão da fibronectina está associada a menor taxas de recidiva tumoral.Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, BrasilUniversidade Estadual Paulista (Unesp)Montovani, Jair Cortez [UNESP]Montovani, Jair Cortez [UNESP]Nakajima, Victor [UNESP]Castilho, Emanuel CeliceDomingues, Maria Aparecida Custódio [UNESP]2016-07-07T12:36:40Z2016-07-07T12:36:40Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article125-132application/pdfhttp://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-3-artigo-04.pdfRevista Brasileira de Cirurgia da Cabeça e Pescoço, v. 40, n. 3, p. 125-132, 2011.0100-2171http://hdl.handle.net/11449/141062ISSN0100-2171-2011-40-03-125-132.pdf61210683869406286121068386940628612106838694062861210683869406280585723113037140Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Cirurgia da Cabeça e Pescoçoinfo:eu-repo/semantics/openAccess2024-08-16T18:44:18Zoai:repositorio.unesp.br:11449/141062Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T18:44:18Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz Nasopharynx Carcinoma: Analyse of the prognostic importance of the immunoexpression of galactin-3 and matrix proteins |
title |
Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz |
spellingShingle |
Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz Montovani, Jair Cortez [UNESP] Nasopharyngeal neoplasms Galectin 3 Fibronectins Laminin Neoplasias nasofaríngeas Galectina 3 Fibronectinas Laminina |
title_short |
Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz |
title_full |
Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz |
title_fullStr |
Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz |
title_full_unstemmed |
Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz |
title_sort |
Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz |
author |
Montovani, Jair Cortez [UNESP] |
author_facet |
Montovani, Jair Cortez [UNESP] Nakajima, Victor [UNESP] Castilho, Emanuel Celice Domingues, Maria Aparecida Custódio [UNESP] |
author_role |
author |
author2 |
Nakajima, Victor [UNESP] Castilho, Emanuel Celice Domingues, Maria Aparecida Custódio [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Montovani, Jair Cortez [UNESP] Montovani, Jair Cortez [UNESP] Nakajima, Victor [UNESP] Castilho, Emanuel Celice Domingues, Maria Aparecida Custódio [UNESP] |
dc.subject.por.fl_str_mv |
Nasopharyngeal neoplasms Galectin 3 Fibronectins Laminin Neoplasias nasofaríngeas Galectina 3 Fibronectinas Laminina |
topic |
Nasopharyngeal neoplasms Galectin 3 Fibronectins Laminin Neoplasias nasofaríngeas Galectina 3 Fibronectinas Laminina |
description |
Objectives: Analyse the expression of galectin-3 and distribution of matrix proteins, laminin, fibronectin and collagen IV, in 30 paraffinated samples of nasopharynx carcinoma (NFC); and correlate the to clinicopathological characteristics, as tumor aggressiveness and survival of individuals. Study design: retrospective clinical study. Methods: The analyses were performed by immunohistochemistry study the expression of the matrix protein and galectin-3 in 30 tissue samples of 26 patients diagnosed with nasopharyngeal carcinoma. Results: The analysis showed that the patients mean age was 48 years-old, with the age peak prevalence was from 60 to 69 years-old, with male predominance of 2:1. The undifferentiated non-keratinized squamous cell carcinoma was predominant in 23 samples (79%), differentiated non-keratinized squamous cell carcinoma was found in 4 samples (13.3%) and keratinized squamous cell carcinoma was found in 3 samples (10%). The laminin expression, which is normally restricted to the vessel walls and lamina propria, was increased in the neoplasic cell matrix in 23 samples (76.7%). Fibronectin was positive in 23 samples (43%). Galectin-3 was observed in 21 samples (70%). Seven cases showed positive correlation between all three proteins. Eleven cases presented positive correlation of laminin and galectin-3 immunoexpression. Conclusions: Fibronectin presence seems to reduce the chance of tumor recurrence and also, increase the survival rate, differently from laminin and galectin-3. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2016-07-07T12:36:40Z 2016-07-07T12:36:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-3-artigo-04.pdf Revista Brasileira de Cirurgia da Cabeça e Pescoço, v. 40, n. 3, p. 125-132, 2011. 0100-2171 http://hdl.handle.net/11449/141062 ISSN0100-2171-2011-40-03-125-132.pdf 6121068386940628 6121068386940628 6121068386940628 6121068386940628 0585723113037140 |
url |
http://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-3-artigo-04.pdf http://hdl.handle.net/11449/141062 |
identifier_str_mv |
Revista Brasileira de Cirurgia da Cabeça e Pescoço, v. 40, n. 3, p. 125-132, 2011. 0100-2171 ISSN0100-2171-2011-40-03-125-132.pdf 6121068386940628 0585723113037140 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Cirurgia da Cabeça e Pescoço |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
125-132 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128183697932288 |