Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz

Detalhes bibliográficos
Autor(a) principal: Montovani, Jair Cortez [UNESP]
Data de Publicação: 2011
Outros Autores: Nakajima, Victor [UNESP], Castilho, Emanuel Celice, Domingues, Maria Aparecida Custódio [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-3-artigo-04.pdf
http://hdl.handle.net/11449/141062
Resumo: Objectives: Analyse the expression of galectin-3 and distribution of matrix proteins, laminin, fibronectin and collagen IV, in 30 paraffinated samples of nasopharynx carcinoma (NFC); and correlate the to clinicopathological characteristics, as tumor aggressiveness and survival of individuals. Study design: retrospective clinical study. Methods: The analyses were performed by immunohistochemistry study the expression of the matrix protein and galectin-3 in 30 tissue samples of 26 patients diagnosed with nasopharyngeal carcinoma. Results: The analysis showed that the patients mean age was 48 years-old, with the age peak prevalence was from 60 to 69 years-old, with male predominance of 2:1. The undifferentiated non-keratinized squamous cell carcinoma was predominant in 23 samples (79%), differentiated non-keratinized squamous cell carcinoma was found in 4 samples (13.3%) and keratinized squamous cell carcinoma was found in 3 samples (10%). The laminin expression, which is normally restricted to the vessel walls and lamina propria, was increased in the neoplasic cell matrix in 23 samples (76.7%). Fibronectin was positive in 23 samples (43%). Galectin-3 was observed in 21 samples (70%). Seven cases showed positive correlation between all three proteins. Eleven cases presented positive correlation of laminin and galectin-3 immunoexpression. Conclusions: Fibronectin presence seems to reduce the chance of tumor recurrence and also, increase the survival rate, differently from laminin and galectin-3.
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spelling Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matrizNasopharynx Carcinoma: Analyse of the prognostic importance of the immunoexpression of galactin-3 and matrix proteinsNasopharyngeal neoplasmsGalectin 3FibronectinsLamininNeoplasias nasofaríngeasGalectina 3FibronectinasLamininaObjectives: Analyse the expression of galectin-3 and distribution of matrix proteins, laminin, fibronectin and collagen IV, in 30 paraffinated samples of nasopharynx carcinoma (NFC); and correlate the to clinicopathological characteristics, as tumor aggressiveness and survival of individuals. Study design: retrospective clinical study. Methods: The analyses were performed by immunohistochemistry study the expression of the matrix protein and galectin-3 in 30 tissue samples of 26 patients diagnosed with nasopharyngeal carcinoma. Results: The analysis showed that the patients mean age was 48 years-old, with the age peak prevalence was from 60 to 69 years-old, with male predominance of 2:1. The undifferentiated non-keratinized squamous cell carcinoma was predominant in 23 samples (79%), differentiated non-keratinized squamous cell carcinoma was found in 4 samples (13.3%) and keratinized squamous cell carcinoma was found in 3 samples (10%). The laminin expression, which is normally restricted to the vessel walls and lamina propria, was increased in the neoplasic cell matrix in 23 samples (76.7%). Fibronectin was positive in 23 samples (43%). Galectin-3 was observed in 21 samples (70%). Seven cases showed positive correlation between all three proteins. Eleven cases presented positive correlation of laminin and galectin-3 immunoexpression. Conclusions: Fibronectin presence seems to reduce the chance of tumor recurrence and also, increase the survival rate, differently from laminin and galectin-3.Objetivo: Estudar a expressão da Galectina-3 e a distribuição das proteínas de matriz, laminina, fibronectina e colágeno IV, em 30 amostras teciduais de carcinoma de nasofaringe (CNF) e correlacionar com as características clinicopatológicas, agressividade tumoral e sobrevida dos indivíduos. Forma de estudo: clínico retrospectivo. Material: Foram estudadas por método imunohistoquímico a expressão das proteínas de matriz e a galectina-3 de 30 amostras teciduais de 26 pacientes com diagnóstico de Carcinoma de Nasofaringe. Resultados: A análise mostrou que a media etária foi de 48 anos, com o pico de prevalência entre 60 a 69 anos, e predominância do sexo masculino de 2:1. O Carcinoma Escamoso Não Ceratinizante Indiferenciado foi mais comum em 23 amostras (76,7%), o Carcinoma Escamoso Não Ceratinizante Diferenciado em 4 amostras (13.3%) e Carcinoma Escamoso Ceratinizante em 3 amostras (10,0%). A expressão da laminina que normalmente é restrita à parede dos vasos e na lâmina própria, estava muito aumentada na matriz das células neoplásicas em 23 amostras (76,7%); a fibronectina foi positiva em 13 amostras (43%) e a galectina-3 foi positiva em 21 amostras (70%). Tivemos correlação positiva da laminina, fibronectina e galectina-3 em 7 amostras (23,3%) e entre laminina e galectina-3 em 11amostras (36,6%). Conclusão: A expressão positiva da Galectina-3 e da laminina não mostrou correlação significativa quanto à agressividade tumoral e a sobrevida dos pacientes, enquanto a expressão da fibronectina está associada a menor taxas de recidiva tumoral.Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, BrasilUniversidade Estadual Paulista (Unesp)Montovani, Jair Cortez [UNESP]Montovani, Jair Cortez [UNESP]Nakajima, Victor [UNESP]Castilho, Emanuel CeliceDomingues, Maria Aparecida Custódio [UNESP]2016-07-07T12:36:40Z2016-07-07T12:36:40Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article125-132application/pdfhttp://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-3-artigo-04.pdfRevista Brasileira de Cirurgia da Cabeça e Pescoço, v. 40, n. 3, p. 125-132, 2011.0100-2171http://hdl.handle.net/11449/141062ISSN0100-2171-2011-40-03-125-132.pdf61210683869406286121068386940628612106838694062861210683869406280585723113037140Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Cirurgia da Cabeça e Pescoçoinfo:eu-repo/semantics/openAccess2024-08-16T18:44:18Zoai:repositorio.unesp.br:11449/141062Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T18:44:18Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
Nasopharynx Carcinoma: Analyse of the prognostic importance of the immunoexpression of galactin-3 and matrix proteins
title Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
spellingShingle Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
Montovani, Jair Cortez [UNESP]
Nasopharyngeal neoplasms
Galectin 3
Fibronectins
Laminin
Neoplasias nasofaríngeas
Galectina 3
Fibronectinas
Laminina
title_short Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
title_full Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
title_fullStr Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
title_full_unstemmed Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
title_sort Carcinoma de nasofaringe: análise da importância prognóstica da imunoexpressão da galectina-3 e proteínas de matriz
author Montovani, Jair Cortez [UNESP]
author_facet Montovani, Jair Cortez [UNESP]
Nakajima, Victor [UNESP]
Castilho, Emanuel Celice
Domingues, Maria Aparecida Custódio [UNESP]
author_role author
author2 Nakajima, Victor [UNESP]
Castilho, Emanuel Celice
Domingues, Maria Aparecida Custódio [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Montovani, Jair Cortez [UNESP]
Montovani, Jair Cortez [UNESP]
Nakajima, Victor [UNESP]
Castilho, Emanuel Celice
Domingues, Maria Aparecida Custódio [UNESP]
dc.subject.por.fl_str_mv Nasopharyngeal neoplasms
Galectin 3
Fibronectins
Laminin
Neoplasias nasofaríngeas
Galectina 3
Fibronectinas
Laminina
topic Nasopharyngeal neoplasms
Galectin 3
Fibronectins
Laminin
Neoplasias nasofaríngeas
Galectina 3
Fibronectinas
Laminina
description Objectives: Analyse the expression of galectin-3 and distribution of matrix proteins, laminin, fibronectin and collagen IV, in 30 paraffinated samples of nasopharynx carcinoma (NFC); and correlate the to clinicopathological characteristics, as tumor aggressiveness and survival of individuals. Study design: retrospective clinical study. Methods: The analyses were performed by immunohistochemistry study the expression of the matrix protein and galectin-3 in 30 tissue samples of 26 patients diagnosed with nasopharyngeal carcinoma. Results: The analysis showed that the patients mean age was 48 years-old, with the age peak prevalence was from 60 to 69 years-old, with male predominance of 2:1. The undifferentiated non-keratinized squamous cell carcinoma was predominant in 23 samples (79%), differentiated non-keratinized squamous cell carcinoma was found in 4 samples (13.3%) and keratinized squamous cell carcinoma was found in 3 samples (10%). The laminin expression, which is normally restricted to the vessel walls and lamina propria, was increased in the neoplasic cell matrix in 23 samples (76.7%). Fibronectin was positive in 23 samples (43%). Galectin-3 was observed in 21 samples (70%). Seven cases showed positive correlation between all three proteins. Eleven cases presented positive correlation of laminin and galectin-3 immunoexpression. Conclusions: Fibronectin presence seems to reduce the chance of tumor recurrence and also, increase the survival rate, differently from laminin and galectin-3.
publishDate 2011
dc.date.none.fl_str_mv 2011
2016-07-07T12:36:40Z
2016-07-07T12:36:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-3-artigo-04.pdf
Revista Brasileira de Cirurgia da Cabeça e Pescoço, v. 40, n. 3, p. 125-132, 2011.
0100-2171
http://hdl.handle.net/11449/141062
ISSN0100-2171-2011-40-03-125-132.pdf
6121068386940628
6121068386940628
6121068386940628
6121068386940628
0585723113037140
url http://www.sbccp.org.br/wp-content/uploads/2014/11/REVISTA-SBCCP-40-3-artigo-04.pdf
http://hdl.handle.net/11449/141062
identifier_str_mv Revista Brasileira de Cirurgia da Cabeça e Pescoço, v. 40, n. 3, p. 125-132, 2011.
0100-2171
ISSN0100-2171-2011-40-03-125-132.pdf
6121068386940628
0585723113037140
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista Brasileira de Cirurgia da Cabeça e Pescoço
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 125-132
application/pdf
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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