Fluoride affects bone repair differently in mice models with distinct bone densities
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jtemb.2016.09.004 http://hdl.handle.net/11449/162272 |
Resumo: | We grouped mice [strains: C57BL/6J (n = 32) and C3H/HeJ (n = 32)] to address the influence of bone density on fluoride's (F's) biological effects. These animals received low-fluoride food and water containing 0 (control group) or 50 ppm of F for up to 28 days. The upper left central incisor was extracted, and the left maxilla was collected at 7, 14, 21, and 28 days for histological and histomorphometric analysis to estimate bone neoformation. Our results showed bone neoformation in all of the evaluated groups, with the presence of bone islets invading the center of the alveoli when replacing the existing connective tissue. Curiously, this biological phenomenon was more evident in the C57BL/6J strain. The histomorphometric analysis confirmed the histological findings in relation to the amount of new bone tissue and showed a decrease in C3H/HeJ mice (control group). Altogether, our results showed differential effects of fluoride bone metabolism, confirming a genetic component in susceptibility to the effects of fluoride. (C) 2016 Elsevier GmbH. All rights reserved. |
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Fluoride affects bone repair differently in mice models with distinct bone densitiesBone repairFluorideMouseBone tissueWe grouped mice [strains: C57BL/6J (n = 32) and C3H/HeJ (n = 32)] to address the influence of bone density on fluoride's (F's) biological effects. These animals received low-fluoride food and water containing 0 (control group) or 50 ppm of F for up to 28 days. The upper left central incisor was extracted, and the left maxilla was collected at 7, 14, 21, and 28 days for histological and histomorphometric analysis to estimate bone neoformation. Our results showed bone neoformation in all of the evaluated groups, with the presence of bone islets invading the center of the alveoli when replacing the existing connective tissue. Curiously, this biological phenomenon was more evident in the C57BL/6J strain. The histomorphometric analysis confirmed the histological findings in relation to the amount of new bone tissue and showed a decrease in C3H/HeJ mice (control group). Altogether, our results showed differential effects of fluoride bone metabolism, confirming a genetic component in susceptibility to the effects of fluoride. (C) 2016 Elsevier GmbH. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Al Octavio Pinheiro Brisolla 9-75, BR-17012901 Sao Paulo, BrazilUniv Fed Sao Carlos, Dept Genet & Evolut, Ctr Biol Sci & Hlth, Km 235, BR-13560970 Sao Paulo, BrazilSao Paulo State Univ, Biosci Inst, Dept Chem & Biochem, Lab Bioassays & Cellular Dynam, Rubiao Jr S-N, BR-18618970 Sao Paulo, BrazilSao Paulo State Univ, Biosci Inst, Dept Chem & Biochem, Lab Bioassays & Cellular Dynam, Rubiao Jr S-N, BR-18618970 Sao Paulo, BrazilFAPESP: 2011/01425-0FAPESP: 2012/02229-2Elsevier B.V.Universidade de São Paulo (USP)Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)Herrera, Paula KennerlyZambolin, Andressa PelissariFernandes, Mileni da SilvaCestari, Tania MaryIano, Flavia GodoyZambuzzi, Willian Fernando [UNESP]Rabelo Buzalaf, Marilia AfonsoOliveira, Rodrigo Cardoso de2018-11-26T17:15:25Z2018-11-26T17:15:25Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article129-134application/pdfhttp://dx.doi.org/10.1016/j.jtemb.2016.09.004Journal Of Trace Elements In Medicine And Biology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 39, p. 129-134, 2017.0946-672Xhttp://hdl.handle.net/11449/16227210.1016/j.jtemb.2016.09.004WOS:000390505900019WOS:000390505900019.pdf2740250822457796Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Trace Elements In Medicine And Biologyinfo:eu-repo/semantics/openAccess2023-10-25T06:06:58Zoai:repositorio.unesp.br:11449/162272Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:53:20.621467Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Fluoride affects bone repair differently in mice models with distinct bone densities |
title |
Fluoride affects bone repair differently in mice models with distinct bone densities |
spellingShingle |
Fluoride affects bone repair differently in mice models with distinct bone densities Herrera, Paula Kennerly Bone repair Fluoride Mouse Bone tissue |
title_short |
Fluoride affects bone repair differently in mice models with distinct bone densities |
title_full |
Fluoride affects bone repair differently in mice models with distinct bone densities |
title_fullStr |
Fluoride affects bone repair differently in mice models with distinct bone densities |
title_full_unstemmed |
Fluoride affects bone repair differently in mice models with distinct bone densities |
title_sort |
Fluoride affects bone repair differently in mice models with distinct bone densities |
author |
Herrera, Paula Kennerly |
author_facet |
Herrera, Paula Kennerly Zambolin, Andressa Pelissari Fernandes, Mileni da Silva Cestari, Tania Mary Iano, Flavia Godoy Zambuzzi, Willian Fernando [UNESP] Rabelo Buzalaf, Marilia Afonso Oliveira, Rodrigo Cardoso de |
author_role |
author |
author2 |
Zambolin, Andressa Pelissari Fernandes, Mileni da Silva Cestari, Tania Mary Iano, Flavia Godoy Zambuzzi, Willian Fernando [UNESP] Rabelo Buzalaf, Marilia Afonso Oliveira, Rodrigo Cardoso de |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Herrera, Paula Kennerly Zambolin, Andressa Pelissari Fernandes, Mileni da Silva Cestari, Tania Mary Iano, Flavia Godoy Zambuzzi, Willian Fernando [UNESP] Rabelo Buzalaf, Marilia Afonso Oliveira, Rodrigo Cardoso de |
dc.subject.por.fl_str_mv |
Bone repair Fluoride Mouse Bone tissue |
topic |
Bone repair Fluoride Mouse Bone tissue |
description |
We grouped mice [strains: C57BL/6J (n = 32) and C3H/HeJ (n = 32)] to address the influence of bone density on fluoride's (F's) biological effects. These animals received low-fluoride food and water containing 0 (control group) or 50 ppm of F for up to 28 days. The upper left central incisor was extracted, and the left maxilla was collected at 7, 14, 21, and 28 days for histological and histomorphometric analysis to estimate bone neoformation. Our results showed bone neoformation in all of the evaluated groups, with the presence of bone islets invading the center of the alveoli when replacing the existing connective tissue. Curiously, this biological phenomenon was more evident in the C57BL/6J strain. The histomorphometric analysis confirmed the histological findings in relation to the amount of new bone tissue and showed a decrease in C3H/HeJ mice (control group). Altogether, our results showed differential effects of fluoride bone metabolism, confirming a genetic component in susceptibility to the effects of fluoride. (C) 2016 Elsevier GmbH. All rights reserved. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-11-26T17:15:25Z 2018-11-26T17:15:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jtemb.2016.09.004 Journal Of Trace Elements In Medicine And Biology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 39, p. 129-134, 2017. 0946-672X http://hdl.handle.net/11449/162272 10.1016/j.jtemb.2016.09.004 WOS:000390505900019 WOS:000390505900019.pdf 2740250822457796 |
url |
http://dx.doi.org/10.1016/j.jtemb.2016.09.004 http://hdl.handle.net/11449/162272 |
identifier_str_mv |
Journal Of Trace Elements In Medicine And Biology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 39, p. 129-134, 2017. 0946-672X 10.1016/j.jtemb.2016.09.004 WOS:000390505900019 WOS:000390505900019.pdf 2740250822457796 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Trace Elements In Medicine And Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
129-134 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128578374598656 |