Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial

Detalhes bibliográficos
Autor(a) principal: Carvalho, Haroldo Teofilo de [UNESP]
Data de Publicação: 2020
Outros Autores: Fioretto, Jose Roberto [UNESP], Bonatto, Rossano Cesar [UNESP], Ribeiro, Cristiane Franco [UNESP], Martin, Joelma Goncalves [UNESP], Carpi, Mario Ferreira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1055/s-0040-1719044
http://hdl.handle.net/11449/209610
Resumo: Extubation failure is a common event in intensive care units. Corticosteroids are effective in preventing failure in adults, but no consensus has been reached on this matter in pediatrics. We assessed the efficacy of intravenous dexamethasone in mechanically ventilated children and adolescents for more than 48hours, with at least one risk factor for failure. Extubations were scheduled 24hours in advance when possible, and patients were randomly assigned into two groups: one group received a loading dose followed by up to four doses of dexamethasone, and the other group received no corticosteroids. Need for reintubation and length of stay in the pediatric intensive care unit were similar in both groups, and frequency of reintubation was 12.9%.
id UNSP_bd92e59d560d9fbc0e3a6e949926d040
oai_identifier_str oai:repositorio.unesp.br:11449/209610
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trialchildrenextubation failuredexamethasoneExtubation failure is a common event in intensive care units. Corticosteroids are effective in preventing failure in adults, but no consensus has been reached on this matter in pediatrics. We assessed the efficacy of intravenous dexamethasone in mechanically ventilated children and adolescents for more than 48hours, with at least one risk factor for failure. Extubations were scheduled 24hours in advance when possible, and patients were randomly assigned into two groups: one group received a loading dose followed by up to four doses of dexamethasone, and the other group received no corticosteroids. Need for reintubation and length of stay in the pediatric intensive care unit were similar in both groups, and frequency of reintubation was 12.9%.Sao Paulo State Univ, UNESP, Dept Pediat, Botucatu Sch Med, Botucatu, SP, BrazilSao Paulo State Univ, UNESP, Dept Pediat, Botucatu Sch Med, Botucatu, SP, BrazilGeorg Thieme Verlag KgUniversidade Estadual Paulista (Unesp)Carvalho, Haroldo Teofilo de [UNESP]Fioretto, Jose Roberto [UNESP]Bonatto, Rossano Cesar [UNESP]Ribeiro, Cristiane Franco [UNESP]Martin, Joelma Goncalves [UNESP]Carpi, Mario Ferreira [UNESP]2021-06-25T12:23:52Z2021-06-25T12:23:52Z2020-11-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7http://dx.doi.org/10.1055/s-0040-1719044Journal Of Pediatric Intensive Care. Stuttgart: Georg Thieme Verlag Kg, 7 p., 2020.2146-4618http://hdl.handle.net/11449/20961010.1055/s-0040-1719044WOS:000584469900001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Pediatric Intensive Careinfo:eu-repo/semantics/openAccess2021-10-23T19:28:17Zoai:repositorio.unesp.br:11449/209610Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:28:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial
title Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial
spellingShingle Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial
Carvalho, Haroldo Teofilo de [UNESP]
children
extubation failure
dexamethasone
title_short Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial
title_full Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial
title_fullStr Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial
title_full_unstemmed Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial
title_sort Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial
author Carvalho, Haroldo Teofilo de [UNESP]
author_facet Carvalho, Haroldo Teofilo de [UNESP]
Fioretto, Jose Roberto [UNESP]
Bonatto, Rossano Cesar [UNESP]
Ribeiro, Cristiane Franco [UNESP]
Martin, Joelma Goncalves [UNESP]
Carpi, Mario Ferreira [UNESP]
author_role author
author2 Fioretto, Jose Roberto [UNESP]
Bonatto, Rossano Cesar [UNESP]
Ribeiro, Cristiane Franco [UNESP]
Martin, Joelma Goncalves [UNESP]
Carpi, Mario Ferreira [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Carvalho, Haroldo Teofilo de [UNESP]
Fioretto, Jose Roberto [UNESP]
Bonatto, Rossano Cesar [UNESP]
Ribeiro, Cristiane Franco [UNESP]
Martin, Joelma Goncalves [UNESP]
Carpi, Mario Ferreira [UNESP]
dc.subject.por.fl_str_mv children
extubation failure
dexamethasone
topic children
extubation failure
dexamethasone
description Extubation failure is a common event in intensive care units. Corticosteroids are effective in preventing failure in adults, but no consensus has been reached on this matter in pediatrics. We assessed the efficacy of intravenous dexamethasone in mechanically ventilated children and adolescents for more than 48hours, with at least one risk factor for failure. Extubations were scheduled 24hours in advance when possible, and patients were randomly assigned into two groups: one group received a loading dose followed by up to four doses of dexamethasone, and the other group received no corticosteroids. Need for reintubation and length of stay in the pediatric intensive care unit were similar in both groups, and frequency of reintubation was 12.9%.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-03
2021-06-25T12:23:52Z
2021-06-25T12:23:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1055/s-0040-1719044
Journal Of Pediatric Intensive Care. Stuttgart: Georg Thieme Verlag Kg, 7 p., 2020.
2146-4618
http://hdl.handle.net/11449/209610
10.1055/s-0040-1719044
WOS:000584469900001
url http://dx.doi.org/10.1055/s-0040-1719044
http://hdl.handle.net/11449/209610
identifier_str_mv Journal Of Pediatric Intensive Care. Stuttgart: Georg Thieme Verlag Kg, 7 p., 2020.
2146-4618
10.1055/s-0040-1719044
WOS:000584469900001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Pediatric Intensive Care
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7
dc.publisher.none.fl_str_mv Georg Thieme Verlag Kg
publisher.none.fl_str_mv Georg Thieme Verlag Kg
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964521600647168

Registros relacionados