Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10266-021-00678-1 http://hdl.handle.net/11449/234030 |
Resumo: | The aim of this study was to evaluate the effect of strontium ranelate (Sr) on post-extraction socket healing in rats submitted to the administration of bisphosphonates. Sixty rats were submitted to the tooth extraction of the first lower molar after 60 days of the daily administration of saline solution (SS) or alendronate (ALN). Then, the animals were allocated into six groups namely CTR: administration of SS during the whole experiment, ALN: administration of ALN during the whole experiment, ALN/SS: application of SS for 30 days after extraction in animals previously treated with ALN, ALN/Sr: application of Sr for 30 days after extraction in animals previously treated with ALN, ALN/S60: ALN therapy interruption 30 days before the extraction followed by the application of SS for 60 days, and ALN/Sr60: ALN therapy interruption 30 days before the tooth extraction followed by the application of Sr for 60 days. The healing of the post-extraction sockets was evaluated by microCT and histomorphometry. The use of ALN induced partial bone necrosis, inflammatory infiltration, and a delay in soft tissue healing; the use of Sr improved the connective tissue organization. Sr has subtle positive effects on the post-extraction healing in animals submitted to the administration of bisphosphonate. |
id |
UNSP_be1d0d936e96e19d6c2de9d1721f14cf |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/234030 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonatesBisphosphonatesBone healingPre-clinical studyStrontium ranelateTooth extractionThe aim of this study was to evaluate the effect of strontium ranelate (Sr) on post-extraction socket healing in rats submitted to the administration of bisphosphonates. Sixty rats were submitted to the tooth extraction of the first lower molar after 60 days of the daily administration of saline solution (SS) or alendronate (ALN). Then, the animals were allocated into six groups namely CTR: administration of SS during the whole experiment, ALN: administration of ALN during the whole experiment, ALN/SS: application of SS for 30 days after extraction in animals previously treated with ALN, ALN/Sr: application of Sr for 30 days after extraction in animals previously treated with ALN, ALN/S60: ALN therapy interruption 30 days before the extraction followed by the application of SS for 60 days, and ALN/Sr60: ALN therapy interruption 30 days before the tooth extraction followed by the application of Sr for 60 days. The healing of the post-extraction sockets was evaluated by microCT and histomorphometry. The use of ALN induced partial bone necrosis, inflammatory infiltration, and a delay in soft tissue healing; the use of Sr improved the connective tissue organization. Sr has subtle positive effects on the post-extraction healing in animals submitted to the administration of bisphosphonate.Department of Diagnosis and Surgery School of Dentistry São Paulo State University (Unesp), Humaitá St., 1680, SPDepartment of Periodontology/Implantology Dental School UFU - Universidade Federal de Uberlândia, MGDepartment of Physiology and Pathology School of Dentistry São Paulo State University (Unesp), Humaitá St., 1680Department of Diagnosis and Surgery School of Dentistry São Paulo State University (Unesp), Humaitá St., 1680, SPDepartment of Physiology and Pathology School of Dentistry São Paulo State University (Unesp), Humaitá St., 1680Universidade Estadual Paulista (UNESP)Universidade Federal de Uberlândia (UFU)Gonçalves, Fernanda Castanheira [UNESP]Mascaro, Bruno Arruda [UNESP]Scardueli, Cássio Rocha [UNESP]de Oliveira, Guilherme José Pimentel LopesSpolidorio, Luis Carlos [UNESP]Marcantonio, Rosemary Adriana Chierici [UNESP]2022-05-01T12:40:47Z2022-05-01T12:40:47Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s10266-021-00678-1Odontology.1618-12551618-1247http://hdl.handle.net/11449/23403010.1007/s10266-021-00678-12-s2.0-85123112020Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOdontologyinfo:eu-repo/semantics/openAccess2022-05-01T12:40:47Zoai:repositorio.unesp.br:11449/234030Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:19:37.719424Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates |
title |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates |
spellingShingle |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates Gonçalves, Fernanda Castanheira [UNESP] Bisphosphonates Bone healing Pre-clinical study Strontium ranelate Tooth extraction |
title_short |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates |
title_full |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates |
title_fullStr |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates |
title_full_unstemmed |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates |
title_sort |
Strontium ranelate improves post-extraction socket healing in rats submitted to the administration of bisphosphonates |
author |
Gonçalves, Fernanda Castanheira [UNESP] |
author_facet |
Gonçalves, Fernanda Castanheira [UNESP] Mascaro, Bruno Arruda [UNESP] Scardueli, Cássio Rocha [UNESP] de Oliveira, Guilherme José Pimentel Lopes Spolidorio, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana Chierici [UNESP] |
author_role |
author |
author2 |
Mascaro, Bruno Arruda [UNESP] Scardueli, Cássio Rocha [UNESP] de Oliveira, Guilherme José Pimentel Lopes Spolidorio, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana Chierici [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Federal de Uberlândia (UFU) |
dc.contributor.author.fl_str_mv |
Gonçalves, Fernanda Castanheira [UNESP] Mascaro, Bruno Arruda [UNESP] Scardueli, Cássio Rocha [UNESP] de Oliveira, Guilherme José Pimentel Lopes Spolidorio, Luis Carlos [UNESP] Marcantonio, Rosemary Adriana Chierici [UNESP] |
dc.subject.por.fl_str_mv |
Bisphosphonates Bone healing Pre-clinical study Strontium ranelate Tooth extraction |
topic |
Bisphosphonates Bone healing Pre-clinical study Strontium ranelate Tooth extraction |
description |
The aim of this study was to evaluate the effect of strontium ranelate (Sr) on post-extraction socket healing in rats submitted to the administration of bisphosphonates. Sixty rats were submitted to the tooth extraction of the first lower molar after 60 days of the daily administration of saline solution (SS) or alendronate (ALN). Then, the animals were allocated into six groups namely CTR: administration of SS during the whole experiment, ALN: administration of ALN during the whole experiment, ALN/SS: application of SS for 30 days after extraction in animals previously treated with ALN, ALN/Sr: application of Sr for 30 days after extraction in animals previously treated with ALN, ALN/S60: ALN therapy interruption 30 days before the extraction followed by the application of SS for 60 days, and ALN/Sr60: ALN therapy interruption 30 days before the tooth extraction followed by the application of Sr for 60 days. The healing of the post-extraction sockets was evaluated by microCT and histomorphometry. The use of ALN induced partial bone necrosis, inflammatory infiltration, and a delay in soft tissue healing; the use of Sr improved the connective tissue organization. Sr has subtle positive effects on the post-extraction healing in animals submitted to the administration of bisphosphonate. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T12:40:47Z 2022-05-01T12:40:47Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10266-021-00678-1 Odontology. 1618-1255 1618-1247 http://hdl.handle.net/11449/234030 10.1007/s10266-021-00678-1 2-s2.0-85123112020 |
url |
http://dx.doi.org/10.1007/s10266-021-00678-1 http://hdl.handle.net/11449/234030 |
identifier_str_mv |
Odontology. 1618-1255 1618-1247 10.1007/s10266-021-00678-1 2-s2.0-85123112020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Odontology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128347829436416 |