Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.ijo.cn/en_publish/2009/3/200903002.pdf http://hdl.handle.net/11449/69616 |
Resumo: | • Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization. |
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Repositório Institucional da UNESP |
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Effect of topical application of 5-FU on the corneoscleral limbus of rabbits5-fluorouracilAntimitotic agentHistopathologyRabbitsTopical applicationfluorouracilanimal experimentanimal modelanimal tissuecontrolled studycornea edemacornea epitheliumcornea limbusdrug effecthistologynonhumanpostoperative periodrabbit• Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization.Department of Ophthalmology Faculdade de Medicina de Botucatu, 18618-000-Botucatu-Sao, Paulo StateDepartment of Pathology Faculdade de Medicina de Botucatu, 18618-000-Botucatu-Sao, Paulo StateDepartment of Ophthalmology Faculdade de Medicina de Botucatu, 18618-000-Botucatu-Sao, Paulo StateDepartment of Pathology Faculdade de Medicina de Botucatu, 18618-000-Botucatu-Sao, Paulo StateUniversidade Estadual Paulista (Unesp)Ferraz, Lucieni C.B. [UNESP]Schellini, Silvana Artioli [UNESP]Marques, Mariângela Esther Alencar [UNESP]2014-05-27T11:22:27Z2014-05-27T11:22:27Z2007-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article291-293application/pdfhttp://www.ijo.cn/en_publish/2009/3/200903002.pdfInternational Journal of Ophthalmology, v. 7, n. 2, p. 291-293, 2007.1672-5123http://hdl.handle.net/11449/696162-s2.0-342485795992-s2.0-34248579599.pdf94202491008354927528116925519142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Ophthalmology0,109info:eu-repo/semantics/openAccess2024-09-03T13:14:41Zoai:repositorio.unesp.br:11449/69616Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of topical application of 5-FU on the corneoscleral limbus of rabbits |
title |
Effect of topical application of 5-FU on the corneoscleral limbus of rabbits |
spellingShingle |
Effect of topical application of 5-FU on the corneoscleral limbus of rabbits Ferraz, Lucieni C.B. [UNESP] 5-fluorouracil Antimitotic agent Histopathology Rabbits Topical application fluorouracil animal experiment animal model animal tissue controlled study cornea edema cornea epithelium cornea limbus drug effect histology nonhuman postoperative period rabbit |
title_short |
Effect of topical application of 5-FU on the corneoscleral limbus of rabbits |
title_full |
Effect of topical application of 5-FU on the corneoscleral limbus of rabbits |
title_fullStr |
Effect of topical application of 5-FU on the corneoscleral limbus of rabbits |
title_full_unstemmed |
Effect of topical application of 5-FU on the corneoscleral limbus of rabbits |
title_sort |
Effect of topical application of 5-FU on the corneoscleral limbus of rabbits |
author |
Ferraz, Lucieni C.B. [UNESP] |
author_facet |
Ferraz, Lucieni C.B. [UNESP] Schellini, Silvana Artioli [UNESP] Marques, Mariângela Esther Alencar [UNESP] |
author_role |
author |
author2 |
Schellini, Silvana Artioli [UNESP] Marques, Mariângela Esther Alencar [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ferraz, Lucieni C.B. [UNESP] Schellini, Silvana Artioli [UNESP] Marques, Mariângela Esther Alencar [UNESP] |
dc.subject.por.fl_str_mv |
5-fluorouracil Antimitotic agent Histopathology Rabbits Topical application fluorouracil animal experiment animal model animal tissue controlled study cornea edema cornea epithelium cornea limbus drug effect histology nonhuman postoperative period rabbit |
topic |
5-fluorouracil Antimitotic agent Histopathology Rabbits Topical application fluorouracil animal experiment animal model animal tissue controlled study cornea edema cornea epithelium cornea limbus drug effect histology nonhuman postoperative period rabbit |
description |
• Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-04-01 2014-05-27T11:22:27Z 2014-05-27T11:22:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.ijo.cn/en_publish/2009/3/200903002.pdf International Journal of Ophthalmology, v. 7, n. 2, p. 291-293, 2007. 1672-5123 http://hdl.handle.net/11449/69616 2-s2.0-34248579599 2-s2.0-34248579599.pdf 9420249100835492 7528116925519142 |
url |
http://www.ijo.cn/en_publish/2009/3/200903002.pdf http://hdl.handle.net/11449/69616 |
identifier_str_mv |
International Journal of Ophthalmology, v. 7, n. 2, p. 291-293, 2007. 1672-5123 2-s2.0-34248579599 2-s2.0-34248579599.pdf 9420249100835492 7528116925519142 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Ophthalmology 0,109 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
291-293 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021369217286144 |