Effect of topical application of 5-FU on the corneoscleral limbus of rabbits

Detalhes bibliográficos
Autor(a) principal: Ferraz, Lucieni C.B. [UNESP]
Data de Publicação: 2007
Outros Autores: Schellini, Silvana Artioli [UNESP], Marques, Mariângela Esther Alencar [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.ijo.cn/en_publish/2009/3/200903002.pdf
http://hdl.handle.net/11449/69616
Resumo: • Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization.
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spelling Effect of topical application of 5-FU on the corneoscleral limbus of rabbits5-fluorouracilAntimitotic agentHistopathologyRabbitsTopical applicationfluorouracilanimal experimentanimal modelanimal tissuecontrolled studycornea edemacornea epitheliumcornea limbusdrug effecthistologynonhumanpostoperative periodrabbit• Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization.Department of Ophthalmology Faculdade de Medicina de Botucatu, 18618-000-Botucatu-Sao, Paulo StateDepartment of Pathology Faculdade de Medicina de Botucatu, 18618-000-Botucatu-Sao, Paulo StateDepartment of Ophthalmology Faculdade de Medicina de Botucatu, 18618-000-Botucatu-Sao, Paulo StateDepartment of Pathology Faculdade de Medicina de Botucatu, 18618-000-Botucatu-Sao, Paulo StateUniversidade Estadual Paulista (Unesp)Ferraz, Lucieni C.B. [UNESP]Schellini, Silvana Artioli [UNESP]Marques, Mariângela Esther Alencar [UNESP]2014-05-27T11:22:27Z2014-05-27T11:22:27Z2007-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article291-293application/pdfhttp://www.ijo.cn/en_publish/2009/3/200903002.pdfInternational Journal of Ophthalmology, v. 7, n. 2, p. 291-293, 2007.1672-5123http://hdl.handle.net/11449/696162-s2.0-342485795992-s2.0-34248579599.pdf94202491008354927528116925519142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Ophthalmology0,109info:eu-repo/semantics/openAccess2024-09-03T13:14:41Zoai:repositorio.unesp.br:11449/69616Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
title Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
spellingShingle Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
Ferraz, Lucieni C.B. [UNESP]
5-fluorouracil
Antimitotic agent
Histopathology
Rabbits
Topical application
fluorouracil
animal experiment
animal model
animal tissue
controlled study
cornea edema
cornea epithelium
cornea limbus
drug effect
histology
nonhuman
postoperative period
rabbit
title_short Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
title_full Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
title_fullStr Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
title_full_unstemmed Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
title_sort Effect of topical application of 5-FU on the corneoscleral limbus of rabbits
author Ferraz, Lucieni C.B. [UNESP]
author_facet Ferraz, Lucieni C.B. [UNESP]
Schellini, Silvana Artioli [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
author_role author
author2 Schellini, Silvana Artioli [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ferraz, Lucieni C.B. [UNESP]
Schellini, Silvana Artioli [UNESP]
Marques, Mariângela Esther Alencar [UNESP]
dc.subject.por.fl_str_mv 5-fluorouracil
Antimitotic agent
Histopathology
Rabbits
Topical application
fluorouracil
animal experiment
animal model
animal tissue
controlled study
cornea edema
cornea epithelium
cornea limbus
drug effect
histology
nonhuman
postoperative period
rabbit
topic 5-fluorouracil
Antimitotic agent
Histopathology
Rabbits
Topical application
fluorouracil
animal experiment
animal model
animal tissue
controlled study
cornea edema
cornea epithelium
cornea limbus
drug effect
histology
nonhuman
postoperative period
rabbit
description • Aim: To observe the effects of topical application of 5-fluorouracil (5-FU) on the rabbits corneal limbus. • Methods: 5-FU was applied topically to the corneoscleral region of rabbits eyes. The animals were sacrificed immediately or 7, 15, 30 and 60 days later, and tissues were submitted to histological examination. • Results: All animals presented corneoscleral deepithelization close to the site of application during the immediate post-operative period, whereas on the 4th postoperative day ulceration was no longer present. Histological examination showed absence of epithelium and slight edema. After one week (G2), 2 animals presented epithelial defects, thickened epithelium with larger basal cells and loose chromatin, and slight subepithelial edema. The remaining groups showed no alterations. • Conclusion: The 5-FU topically on the corneoscleral limbus postpone the epitelization.
publishDate 2007
dc.date.none.fl_str_mv 2007-04-01
2014-05-27T11:22:27Z
2014-05-27T11:22:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.ijo.cn/en_publish/2009/3/200903002.pdf
International Journal of Ophthalmology, v. 7, n. 2, p. 291-293, 2007.
1672-5123
http://hdl.handle.net/11449/69616
2-s2.0-34248579599
2-s2.0-34248579599.pdf
9420249100835492
7528116925519142
url http://www.ijo.cn/en_publish/2009/3/200903002.pdf
http://hdl.handle.net/11449/69616
identifier_str_mv International Journal of Ophthalmology, v. 7, n. 2, p. 291-293, 2007.
1672-5123
2-s2.0-34248579599
2-s2.0-34248579599.pdf
9420249100835492
7528116925519142
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Ophthalmology
0,109
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 291-293
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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