Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.acgpubs.org/RNP/2013/Volume7/Abstracts%207.1/5-RNP-1206-102.htm http://hdl.handle.net/11449/74321 |
Resumo: | Syngonanthus bisulcatus Rul., popularly known in Brazil as sempre-vivas chapadeira, is a plant of the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. In this work, the ethanolic extract (EtOHE), flavonoid-rich (FRF), and flavonoid-deficient (FDF) fractions obtained from scapes of S. bisulcatus were investigated for gastroprotection in both rats and mice. The activity was evaluated in models for induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation). The participation of mucus and prostaglandin E2 were also investigated. Sb-EtOHE (50, 100, and 250 mg/kg, p.o.), Sb-FRF (100 mg/kg, p.o.), and Sb-FDF (100 mg/kg, p.o.) significantly reduced gastric injuries in all models. Sb-FRF altered gastric juice parameters after pylorus ligation. Sb-FRF and Sb-FDF (100 mg/kg each, p.o.) significantly increased the amount of adherent mucus in the gastric mucosa. Sb-FRF maintained the mucosal levels of prostaglandin after the administration of indomethacin. The results indicate that Sb-EtOHE, Sb-FRF and Sb-FDF have significant gastroprotective activity. The observed gastroprotective effects of S. bisulcatus probably involve the participation of both mucus and prostaglandins, integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors. © 2013 Reproduction is free for scientific studies. |
id |
UNSP_bfc6d7b719856dc1017e618ce2180b6a |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/74321 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus RulEriocaulaceaeGastric ulcerGastroprotective activityMedicinal plantsSyngonanthus bisulcatusantiulcer agentcimetidinelansoprazoleplant extractprostaglandin E2Syngonanthus bisulcatus extractunclassified druganimal experimentanimal modelcontrolled studydose responsedrug dose comparisondrug effectdrug efficacydrug mechanismdrug screeningmalemousenonhumanphytochemistryratstomach juicestomach mucosastomach protectionstomach ulcerMusRattusSyngonanthusSyngonanthus bisulcatus Rul., popularly known in Brazil as sempre-vivas chapadeira, is a plant of the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. In this work, the ethanolic extract (EtOHE), flavonoid-rich (FRF), and flavonoid-deficient (FDF) fractions obtained from scapes of S. bisulcatus were investigated for gastroprotection in both rats and mice. The activity was evaluated in models for induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation). The participation of mucus and prostaglandin E2 were also investigated. Sb-EtOHE (50, 100, and 250 mg/kg, p.o.), Sb-FRF (100 mg/kg, p.o.), and Sb-FDF (100 mg/kg, p.o.) significantly reduced gastric injuries in all models. Sb-FRF altered gastric juice parameters after pylorus ligation. Sb-FRF and Sb-FDF (100 mg/kg each, p.o.) significantly increased the amount of adherent mucus in the gastric mucosa. Sb-FRF maintained the mucosal levels of prostaglandin after the administration of indomethacin. The results indicate that Sb-EtOHE, Sb-FRF and Sb-FDF have significant gastroprotective activity. The observed gastroprotective effects of S. bisulcatus probably involve the participation of both mucus and prostaglandins, integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors. © 2013 Reproduction is free for scientific studies.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Departamento de Ciências Farmacêuticas Centro de Ciências da Saúde Universidade Federal da Paraíba (UFPB), João Pessoa, PBDepartamento de Fisiologia e Biofísica Instituto de Biologia Universidade Estadual de Campinas (UNICAMP), Cx. Postal 6109, CEP. 13083-970, Campinas, SPDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, SPDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, SPUniversidade Federal da Paraíba (UFPB)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Batista, Leônia Mariade Almeida, Ana Beatriz AlbinoLima, Gedson Rodrigues de MoraisFalcão, Heloina de SousaFerreira, Anderson LuizMagri, Luciana de PietroCoelho, Roberta Gomes [UNESP]Calvo, Tamara Regina [UNESP]Vilegas, Wagner [UNESP]Brito, Alba Regina Monteiro Souza2014-05-27T11:27:33Z2014-05-27T11:27:33Z2013-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article35-44application/pdfhttp://www.acgpubs.org/RNP/2013/Volume7/Abstracts%207.1/5-RNP-1206-102.htmRecords of Natural Products, v. 7, n. 1, p. 35-44, 2013.1307-6167http://hdl.handle.net/11449/74321WOS:0003195552000052-s2.0-848703873492-s2.0-84870387349.pdf0000-0003-3032-2556Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRecords of Natural Products1.3110,517info:eu-repo/semantics/openAccess2023-10-02T06:02:30Zoai:repositorio.unesp.br:11449/74321Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-02T06:02:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul |
title |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul |
spellingShingle |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul Batista, Leônia Maria Eriocaulaceae Gastric ulcer Gastroprotective activity Medicinal plants Syngonanthus bisulcatus antiulcer agent cimetidine lansoprazole plant extract prostaglandin E2 Syngonanthus bisulcatus extract unclassified drug animal experiment animal model controlled study dose response drug dose comparison drug effect drug efficacy drug mechanism drug screening male mouse nonhuman phytochemistry rat stomach juice stomach mucosa stomach protection stomach ulcer Mus Rattus Syngonanthus |
title_short |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul |
title_full |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul |
title_fullStr |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul |
title_full_unstemmed |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul |
title_sort |
Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul |
author |
Batista, Leônia Maria |
author_facet |
Batista, Leônia Maria de Almeida, Ana Beatriz Albino Lima, Gedson Rodrigues de Morais Falcão, Heloina de Sousa Ferreira, Anderson Luiz Magri, Luciana de Pietro Coelho, Roberta Gomes [UNESP] Calvo, Tamara Regina [UNESP] Vilegas, Wagner [UNESP] Brito, Alba Regina Monteiro Souza |
author_role |
author |
author2 |
de Almeida, Ana Beatriz Albino Lima, Gedson Rodrigues de Morais Falcão, Heloina de Sousa Ferreira, Anderson Luiz Magri, Luciana de Pietro Coelho, Roberta Gomes [UNESP] Calvo, Tamara Regina [UNESP] Vilegas, Wagner [UNESP] Brito, Alba Regina Monteiro Souza |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal da Paraíba (UFPB) Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Batista, Leônia Maria de Almeida, Ana Beatriz Albino Lima, Gedson Rodrigues de Morais Falcão, Heloina de Sousa Ferreira, Anderson Luiz Magri, Luciana de Pietro Coelho, Roberta Gomes [UNESP] Calvo, Tamara Regina [UNESP] Vilegas, Wagner [UNESP] Brito, Alba Regina Monteiro Souza |
dc.subject.por.fl_str_mv |
Eriocaulaceae Gastric ulcer Gastroprotective activity Medicinal plants Syngonanthus bisulcatus antiulcer agent cimetidine lansoprazole plant extract prostaglandin E2 Syngonanthus bisulcatus extract unclassified drug animal experiment animal model controlled study dose response drug dose comparison drug effect drug efficacy drug mechanism drug screening male mouse nonhuman phytochemistry rat stomach juice stomach mucosa stomach protection stomach ulcer Mus Rattus Syngonanthus |
topic |
Eriocaulaceae Gastric ulcer Gastroprotective activity Medicinal plants Syngonanthus bisulcatus antiulcer agent cimetidine lansoprazole plant extract prostaglandin E2 Syngonanthus bisulcatus extract unclassified drug animal experiment animal model controlled study dose response drug dose comparison drug effect drug efficacy drug mechanism drug screening male mouse nonhuman phytochemistry rat stomach juice stomach mucosa stomach protection stomach ulcer Mus Rattus Syngonanthus |
description |
Syngonanthus bisulcatus Rul., popularly known in Brazil as sempre-vivas chapadeira, is a plant of the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. In this work, the ethanolic extract (EtOHE), flavonoid-rich (FRF), and flavonoid-deficient (FDF) fractions obtained from scapes of S. bisulcatus were investigated for gastroprotection in both rats and mice. The activity was evaluated in models for induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation). The participation of mucus and prostaglandin E2 were also investigated. Sb-EtOHE (50, 100, and 250 mg/kg, p.o.), Sb-FRF (100 mg/kg, p.o.), and Sb-FDF (100 mg/kg, p.o.) significantly reduced gastric injuries in all models. Sb-FRF altered gastric juice parameters after pylorus ligation. Sb-FRF and Sb-FDF (100 mg/kg each, p.o.) significantly increased the amount of adherent mucus in the gastric mucosa. Sb-FRF maintained the mucosal levels of prostaglandin after the administration of indomethacin. The results indicate that Sb-EtOHE, Sb-FRF and Sb-FDF have significant gastroprotective activity. The observed gastroprotective effects of S. bisulcatus probably involve the participation of both mucus and prostaglandins, integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors. © 2013 Reproduction is free for scientific studies. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 2014-05-27T11:27:33Z 2014-05-27T11:27:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.acgpubs.org/RNP/2013/Volume7/Abstracts%207.1/5-RNP-1206-102.htm Records of Natural Products, v. 7, n. 1, p. 35-44, 2013. 1307-6167 http://hdl.handle.net/11449/74321 WOS:000319555200005 2-s2.0-84870387349 2-s2.0-84870387349.pdf 0000-0003-3032-2556 |
url |
http://www.acgpubs.org/RNP/2013/Volume7/Abstracts%207.1/5-RNP-1206-102.htm http://hdl.handle.net/11449/74321 |
identifier_str_mv |
Records of Natural Products, v. 7, n. 1, p. 35-44, 2013. 1307-6167 WOS:000319555200005 2-s2.0-84870387349 2-s2.0-84870387349.pdf 0000-0003-3032-2556 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Records of Natural Products 1.311 0,517 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
35-44 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964399829516288 |