Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida

Detalhes bibliográficos
Autor(a) principal: Dantas, Sara Bruna Souza
Data de Publicação: 2022
Outros Autores: Moraes, Gleys Kellen Aquino, Araujo, Angela Regina [UNESP], Chapla, Vanessa Mara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/14786419.2022.2115492
http://hdl.handle.net/11449/241542
Resumo: Coriolopsis rigida was isolated as an endophytic fungus from the medicinal plant Cochlospermum regium, and their production of secondary metabolites has not yet been investigated. Thus, the endophyte was cultivated on rice solid media to evaluate its ability to produce bioactive compounds and then the chloroform extract was obtained. Two phenolic compounds, tyrosol (1) and a new natural product p-hydroxyphenylacetamide (2), were isolated from the extract. The structures of the compounds were elucidated mainly by NMR. The extract showed potent antioxidant activity with an efficient concentration (EC50) value of 0.33 mg mL−1. Additionally, demonstrated allelopathic activity inhibited the seedling growth of Lactuca sativa L. and Raphanus sativus L. by 63% and 55%, respectively.
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spelling Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigidaallelopathic activityAntioxidant activityCochlospermum regiumendophyteCoriolopsis rigida was isolated as an endophytic fungus from the medicinal plant Cochlospermum regium, and their production of secondary metabolites has not yet been investigated. Thus, the endophyte was cultivated on rice solid media to evaluate its ability to produce bioactive compounds and then the chloroform extract was obtained. Two phenolic compounds, tyrosol (1) and a new natural product p-hydroxyphenylacetamide (2), were isolated from the extract. The structures of the compounds were elucidated mainly by NMR. The extract showed potent antioxidant activity with an efficient concentration (EC50) value of 0.33 mg mL−1. Additionally, demonstrated allelopathic activity inhibited the seedling growth of Lactuca sativa L. and Raphanus sativus L. by 63% and 55%, respectively.Programa de Pós-gaduação em Química Universidade Federal do Tocantins UFT, TOPrograma de Pós-gaduação em Biotecnologia Universidade Federal do Tocantins UFT, TODepartamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo UNESP, SPDepartamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo UNESP, SPUFTUniversidade Estadual Paulista (UNESP)Dantas, Sara Bruna SouzaMoraes, Gleys Kellen AquinoAraujo, Angela Regina [UNESP]Chapla, Vanessa Mara2023-03-01T21:09:01Z2023-03-01T21:09:01Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/14786419.2022.2115492Natural Product Research.1478-64271478-6419http://hdl.handle.net/11449/24154210.1080/14786419.2022.21154922-s2.0-85136480923Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Researchinfo:eu-repo/semantics/openAccess2023-03-01T21:09:01Zoai:repositorio.unesp.br:11449/241542Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T21:09:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
title Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
spellingShingle Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
Dantas, Sara Bruna Souza
allelopathic activity
Antioxidant activity
Cochlospermum regium
endophyte
title_short Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
title_full Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
title_fullStr Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
title_full_unstemmed Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
title_sort Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
author Dantas, Sara Bruna Souza
author_facet Dantas, Sara Bruna Souza
Moraes, Gleys Kellen Aquino
Araujo, Angela Regina [UNESP]
Chapla, Vanessa Mara
author_role author
author2 Moraes, Gleys Kellen Aquino
Araujo, Angela Regina [UNESP]
Chapla, Vanessa Mara
author2_role author
author
author
dc.contributor.none.fl_str_mv UFT
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Dantas, Sara Bruna Souza
Moraes, Gleys Kellen Aquino
Araujo, Angela Regina [UNESP]
Chapla, Vanessa Mara
dc.subject.por.fl_str_mv allelopathic activity
Antioxidant activity
Cochlospermum regium
endophyte
topic allelopathic activity
Antioxidant activity
Cochlospermum regium
endophyte
description Coriolopsis rigida was isolated as an endophytic fungus from the medicinal plant Cochlospermum regium, and their production of secondary metabolites has not yet been investigated. Thus, the endophyte was cultivated on rice solid media to evaluate its ability to produce bioactive compounds and then the chloroform extract was obtained. Two phenolic compounds, tyrosol (1) and a new natural product p-hydroxyphenylacetamide (2), were isolated from the extract. The structures of the compounds were elucidated mainly by NMR. The extract showed potent antioxidant activity with an efficient concentration (EC50) value of 0.33 mg mL−1. Additionally, demonstrated allelopathic activity inhibited the seedling growth of Lactuca sativa L. and Raphanus sativus L. by 63% and 55%, respectively.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T21:09:01Z
2023-03-01T21:09:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/14786419.2022.2115492
Natural Product Research.
1478-6427
1478-6419
http://hdl.handle.net/11449/241542
10.1080/14786419.2022.2115492
2-s2.0-85136480923
url http://dx.doi.org/10.1080/14786419.2022.2115492
http://hdl.handle.net/11449/241542
identifier_str_mv Natural Product Research.
1478-6427
1478-6419
10.1080/14786419.2022.2115492
2-s2.0-85136480923
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Natural Product Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1803047193344475136

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