A novel biomagnetic approach to study caecocolonic motility in humans

• Autor(a) principal: Romeiro, Fernando Gomes [UNESP]
• Data de Publicação: 2006
• Outros Autores: Cora, L. A., De Andreis, U., Americo, M. F., Oliveira, R. B., Baffa, O., Miranda, J. R. A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1111/j.1365-2982.2006.00838.x; http://hdl.handle.net/11449/11239
• topic: Alternating Current Biosusceptometry; biomagnetism; colonic motility; feeding response

Motility patterns play a major role in human colonic functions; however, its physiological significance is poorly understood. Several studies have been introducing the Alternating Current Biosusceptometry (ACB) as a valuable tool in gastroenterology and pharmaceutical research. Using gold standard techniques, great effort has been made to validate ACB as a method for measuring gastrointestinal motility in humans and animals. The aim of this study was to evaluate caecocolonic motility and its response to a meal in healthy volunteers. The results showed a dominant frequency of 3.17 +/- 0.13 cycles per minute (mean +/- SD) that remained unchanged even after a standardized meal (P > 0.01). The colonic response to a meal was recorded as a considerable increase in amplitude, reflected by motility index (P < 0.01) and was observed for all the volunteers. The caecocolonic motility could be assessed by the ACB providing new insights into physiological patterns of motility. Moreover, the method is non-invasive, radiation-free, cost-effective and independent of bowel preparation.