Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.cbra.org.br/portal/publicacoes/ar/2010/araj2010.html http://hdl.handle.net/11449/126730 |
Resumo: | Acquisition of the luteinizing hormone receptor (LHR) on granulosa cells of the dominant follicle is essential to physiological LH-mediated effects on the final stages of follicular growth, final maturation of the oocyte, ovulation and luteinization of the follicular wall. Therefore, LHR plays a key role in the final maturation of the dominant follicle from follicular dominance to ovulation. In this review, the basic molecular aspects of LHR (gene structure, alternative splicing and ligand mediated activation) and the physiological regulatory aspects (changes in LHR expression during antral follicle growth and a post-transcriptional model for downregulation of LHR transcripts) are addressed. Despite the accumulation of considerable amounts of information about LHR, a comprehensive and broad model for the role of LHR in bovine antral follicle growth is missing. Questions such as the function for alternative LHR transcripts, their transcriptional and translational regulation, and how the transcripts go to the cell surface and interact with ligands remain to be elucidated in bovine and other species. |
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Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a reviewBos indicusBos taurusCattleFolliculogenesisGranulosa cellsLHRLuteinizing hormone receptorOvulationAcquisition of the luteinizing hormone receptor (LHR) on granulosa cells of the dominant follicle is essential to physiological LH-mediated effects on the final stages of follicular growth, final maturation of the oocyte, ovulation and luteinization of the follicular wall. Therefore, LHR plays a key role in the final maturation of the dominant follicle from follicular dominance to ovulation. In this review, the basic molecular aspects of LHR (gene structure, alternative splicing and ligand mediated activation) and the physiological regulatory aspects (changes in LHR expression during antral follicle growth and a post-transcriptional model for downregulation of LHR transcripts) are addressed. Despite the accumulation of considerable amounts of information about LHR, a comprehensive and broad model for the role of LHR in bovine antral follicle growth is missing. Questions such as the function for alternative LHR transcripts, their transcriptional and translational regulation, and how the transcripts go to the cell surface and interact with ligands remain to be elucidated in bovine and other species.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)MFGNUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciências Biológicas, Faculdade de Ciências e Letras de Assis, Assis, Avenida Dom Antônio, 2100, Vila Glória, CEP 19800000, SP, BrasilDept. of Biological Sciences, College of Sciences and Letters, UNESP, Campus Assis, SP, BrazilDept. Pharmacology Biosciences Institute, UNESP, Campus Botucatu, SP, BrazilDept. Physiology, Biosciences Institute, UNESP, Campus Botucatu, SP, BrazilMFGN - 2001/08743-5Universidade Estadual Paulista (Unesp)Nogueira, Marcelo Fábio Gouveia [UNESP]Fernandes, Paulo [UNESP]Ereno, Ronaldo Luiz [UNESP]Simões, Renato Arantes Lima [UNESP]Buratini Júnior, José [UNESP]Barros, Ciro Moraes [UNESP]2015-08-21T17:52:58Z2015-08-21T17:52:58Z2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article51-64application/pdfhttp://www.cbra.org.br/portal/publicacoes/ar/2010/araj2010.htmlAnimal Reproduction, v. 7, n. 2, p. 51-64, 2010.1806-9614http://hdl.handle.net/11449/126730ISSN1806-9614-2010-07-02-51-64.pdf37349331524144127795883009987806Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnimal Reproduction0.9910,308info:eu-repo/semantics/openAccess2024-06-13T17:38:07Zoai:repositorio.unesp.br:11449/126730Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-13T17:38:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review |
title |
Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review |
spellingShingle |
Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review Nogueira, Marcelo Fábio Gouveia [UNESP] Bos indicus Bos taurus Cattle Folliculogenesis Granulosa cells LHR Luteinizing hormone receptor Ovulation |
title_short |
Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review |
title_full |
Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review |
title_fullStr |
Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review |
title_full_unstemmed |
Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review |
title_sort |
Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review |
author |
Nogueira, Marcelo Fábio Gouveia [UNESP] |
author_facet |
Nogueira, Marcelo Fábio Gouveia [UNESP] Fernandes, Paulo [UNESP] Ereno, Ronaldo Luiz [UNESP] Simões, Renato Arantes Lima [UNESP] Buratini Júnior, José [UNESP] Barros, Ciro Moraes [UNESP] |
author_role |
author |
author2 |
Fernandes, Paulo [UNESP] Ereno, Ronaldo Luiz [UNESP] Simões, Renato Arantes Lima [UNESP] Buratini Júnior, José [UNESP] Barros, Ciro Moraes [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Nogueira, Marcelo Fábio Gouveia [UNESP] Fernandes, Paulo [UNESP] Ereno, Ronaldo Luiz [UNESP] Simões, Renato Arantes Lima [UNESP] Buratini Júnior, José [UNESP] Barros, Ciro Moraes [UNESP] |
dc.subject.por.fl_str_mv |
Bos indicus Bos taurus Cattle Folliculogenesis Granulosa cells LHR Luteinizing hormone receptor Ovulation |
topic |
Bos indicus Bos taurus Cattle Folliculogenesis Granulosa cells LHR Luteinizing hormone receptor Ovulation |
description |
Acquisition of the luteinizing hormone receptor (LHR) on granulosa cells of the dominant follicle is essential to physiological LH-mediated effects on the final stages of follicular growth, final maturation of the oocyte, ovulation and luteinization of the follicular wall. Therefore, LHR plays a key role in the final maturation of the dominant follicle from follicular dominance to ovulation. In this review, the basic molecular aspects of LHR (gene structure, alternative splicing and ligand mediated activation) and the physiological regulatory aspects (changes in LHR expression during antral follicle growth and a post-transcriptional model for downregulation of LHR transcripts) are addressed. Despite the accumulation of considerable amounts of information about LHR, a comprehensive and broad model for the role of LHR in bovine antral follicle growth is missing. Questions such as the function for alternative LHR transcripts, their transcriptional and translational regulation, and how the transcripts go to the cell surface and interact with ligands remain to be elucidated in bovine and other species. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2015-08-21T17:52:58Z 2015-08-21T17:52:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.cbra.org.br/portal/publicacoes/ar/2010/araj2010.html Animal Reproduction, v. 7, n. 2, p. 51-64, 2010. 1806-9614 http://hdl.handle.net/11449/126730 ISSN1806-9614-2010-07-02-51-64.pdf 3734933152414412 7795883009987806 |
url |
http://www.cbra.org.br/portal/publicacoes/ar/2010/araj2010.html http://hdl.handle.net/11449/126730 |
identifier_str_mv |
Animal Reproduction, v. 7, n. 2, p. 51-64, 2010. 1806-9614 ISSN1806-9614-2010-07-02-51-64.pdf 3734933152414412 7795883009987806 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Animal Reproduction 0.991 0,308 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
51-64 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045261575979008 |