Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000200002&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/136948 |
Resumo: | Objectives: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. Materials and methods: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries; duration of the estrous cycle, sexual behavior, and fertility after natural mating. Results: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. Conclusions: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively. |
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Reproductive physiology, and physical and sexual development of female offspring born to diabetic damsDesenvolvimento físico, sexual e fisiologia reprodutiva da prole feminina de ratas diabéticasSexual behaviorPhysical developmentDiabetesFemale reproductive physiologyFemale ratStreptozotocinComportamento sexualDesenvolvimento físicoDiabetesFisiologia reprodutiva femininaRataEstreptozotocinaObjectives: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. Materials and methods: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries; duration of the estrous cycle, sexual behavior, and fertility after natural mating. Results: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. Conclusions: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively.Objetivos: O objetivo deste estudo foi avaliar o desenvolvimento físico e sexual e a fisiologia reprodutiva de ratas que se desenvolveram em condições hiperglicêmicas in utero e lactação. Materiais e métodos: Para induzir o diabetes nas ratas, foi utilizada estreptozotocina em dose única via intravenosa antes do acasalamento. A prole feminina foi avaliada por meio dos seguintes parâmetros: o desenvolvimento físico; a idade de abertura vaginal e do primeiro estro, peso e avaliação histológica do útero e ovários; a duração do ciclo estral, o comportamento sexual e a fertilidade após acasalamentos naturais. Resultados: O diabetes materno provocou, na prole feminina, retardo no desenvolvimento físico; diminuição do peso dos ovários e do número de folículos; a performance reprodutiva foi inferior à do grupo controle. Conclusões: Concluiu-se que a exposição aos meios intrauterino e lactacional hiperglicêmicos provocou retardo no desenvolvimento físico e sexual e prejudicou a fisiologia reprodutiva de ratas.Center of Biological and Health Sciences (CCBS), Universidade Estadual do Oeste do Paraná (Unioeste), Cascavel, PR, BrazilGraduate Program in Cellular and Structural Biology, Institute of Biology, Universidade Estadual de Campinas (Unicamp), Campinas, SP, BrazilGraduate Program in Geral and Applied Biology, Institute of Biosciences, Universidade Estadual Paulista (Unesp), Botucatu, Sao Paulo, SP, BrazilDepartment of Gynecology and Obstetrics, Botucatu Medical School, Unesp, Botucatu, Sao Paulo, SP, BrazilCentro de Assistência Toxicológica, Institute of Biosciences, Botucatu, Sao Paulo, SP, BrazilDepartment of Morphology, Institute of Biosciences, Unesp, Botucatu, Sao Paulo, SP, BrazilUniversidade Estadual Paulista (Unesp)Universidade Estadual do Oeste do Paraná [UNIOESTE]Universidade Estadual de Campinas (UNICAMP)Spadotto, Raquel [UNESP]Damasceno, Débora Cristina [UNESP]Godinho, Antônio F. [UNESP]Amorim, Elaine Manoela PortoPerobelli, Juliana ElaineKempinas, Wilma De Grava [UNESP]2016-04-01T18:43:26Z2016-04-01T18:43:26Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article96-103application/pdfhttp://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000200002&lng=en&nrm=iso&tlng=enArquivos Brasileiros de Endocrinologia e Metabologia, v. 56, n. 2, p. 96-103, 2012.1677-9487http://hdl.handle.net/11449/136948ISSN1677-9487-2012-56-02-96-103.pdf6326450271169741Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros de Endocrinologia e Metabologiainfo:eu-repo/semantics/openAccess2024-08-16T14:06:43Zoai:repositorio.unesp.br:11449/136948Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams Desenvolvimento físico, sexual e fisiologia reprodutiva da prole feminina de ratas diabéticas |
| title |
Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams |
| spellingShingle |
Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams Spadotto, Raquel [UNESP] Sexual behavior Physical development Diabetes Female reproductive physiology Female rat Streptozotocin Comportamento sexual Desenvolvimento físico Diabetes Fisiologia reprodutiva feminina Rata Estreptozotocina |
| title_short |
Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams |
| title_full |
Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams |
| title_fullStr |
Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams |
| title_full_unstemmed |
Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams |
| title_sort |
Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams |
| author |
Spadotto, Raquel [UNESP] |
| author_facet |
Spadotto, Raquel [UNESP] Damasceno, Débora Cristina [UNESP] Godinho, Antônio F. [UNESP] Amorim, Elaine Manoela Porto Perobelli, Juliana Elaine Kempinas, Wilma De Grava [UNESP] |
| author_role |
author |
| author2 |
Damasceno, Débora Cristina [UNESP] Godinho, Antônio F. [UNESP] Amorim, Elaine Manoela Porto Perobelli, Juliana Elaine Kempinas, Wilma De Grava [UNESP] |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual do Oeste do Paraná [UNIOESTE] Universidade Estadual de Campinas (UNICAMP) |
| dc.contributor.author.fl_str_mv |
Spadotto, Raquel [UNESP] Damasceno, Débora Cristina [UNESP] Godinho, Antônio F. [UNESP] Amorim, Elaine Manoela Porto Perobelli, Juliana Elaine Kempinas, Wilma De Grava [UNESP] |
| dc.subject.por.fl_str_mv |
Sexual behavior Physical development Diabetes Female reproductive physiology Female rat Streptozotocin Comportamento sexual Desenvolvimento físico Diabetes Fisiologia reprodutiva feminina Rata Estreptozotocina |
| topic |
Sexual behavior Physical development Diabetes Female reproductive physiology Female rat Streptozotocin Comportamento sexual Desenvolvimento físico Diabetes Fisiologia reprodutiva feminina Rata Estreptozotocina |
| description |
Objectives: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. Materials and methods: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries; duration of the estrous cycle, sexual behavior, and fertility after natural mating. Results: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. Conclusions: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2016-04-01T18:43:26Z 2016-04-01T18:43:26Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000200002&lng=en&nrm=iso&tlng=en Arquivos Brasileiros de Endocrinologia e Metabologia, v. 56, n. 2, p. 96-103, 2012. 1677-9487 http://hdl.handle.net/11449/136948 ISSN1677-9487-2012-56-02-96-103.pdf 6326450271169741 |
| url |
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000200002&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/136948 |
| identifier_str_mv |
Arquivos Brasileiros de Endocrinologia e Metabologia, v. 56, n. 2, p. 96-103, 2012. 1677-9487 ISSN1677-9487-2012-56-02-96-103.pdf 6326450271169741 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia e Metabologia |
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info:eu-repo/semantics/openAccess |
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openAccess |
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96-103 application/pdf |
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Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1808128125229334528 |