Metabolic assessment in patients with urinary lithiasis

Detalhes bibliográficos
Autor(a) principal: Amaro, Carmen R. [UNESP]
Data de Publicação: 2005
Outros Autores: Goldberg, José [UNESP], Amaro, João Luiz [UNESP], Padovani, Carlos Roberto [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1677-55382005000100006
http://hdl.handle.net/11449/11481
Resumo: INTRODUCTION: Metabolic investigation in patients with urinary lithiasis is very important for preventing recurrence of disease. The objective of this work was to diagnose and to determine the prevalence of metabolic disorders, to assess the quality of the water consumed and volume of diuresis as potential risk factors for this pathology. PATIENTS and METHODS: We studied 182 patients older than 12 years. We included patients with history and/or imaging tests confirming at least 2 stones, with creatinine clearance > 60 mL/min and negative urine culture. The protocol consisted in the collection of 2, 24-hour urine samples, for dosing Ca, P, uric acid, Na, K, Mg, Ox and Ci, glycemia and serum levels of Ca, P, Uric acid, Na, K, Cl, Mg, U and Cr, urinary pH and urinary acidification test. RESULTS: 158 patients fulfilled the inclusion criteria. Among these, 151 (95.5%) presented metabolic changes, with 94 (62.2%) presenting isolated metabolic change and 57 (37.8%) had mixed changes. The main disorders detected were hypercalciuria (74%), hypocitraturia (37.3%), hyperoxaluria (24.1%), hypomagnesuria (21%), hyperuricosuria (20.2%), primary hyperparathyroidism (1.8%) secondary hyperparathyroidism (0.6%) and renal tubular acidosis (0.6). CONCLUSION: Metabolic change was diagnosed in 95.5% of patients. These results warrant the metabolic study and follow-up in patients with recurrent lithiasis in order to decrease the recurrence rate through specific treatments, modification in alimentary and behavioral habits.
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spelling Metabolic assessment in patients with urinary lithiasisurolithiasisrisk factorssaltsmetabolic diseasefollow-upstudiesINTRODUCTION: Metabolic investigation in patients with urinary lithiasis is very important for preventing recurrence of disease. The objective of this work was to diagnose and to determine the prevalence of metabolic disorders, to assess the quality of the water consumed and volume of diuresis as potential risk factors for this pathology. PATIENTS and METHODS: We studied 182 patients older than 12 years. We included patients with history and/or imaging tests confirming at least 2 stones, with creatinine clearance > 60 mL/min and negative urine culture. The protocol consisted in the collection of 2, 24-hour urine samples, for dosing Ca, P, uric acid, Na, K, Mg, Ox and Ci, glycemia and serum levels of Ca, P, Uric acid, Na, K, Cl, Mg, U and Cr, urinary pH and urinary acidification test. RESULTS: 158 patients fulfilled the inclusion criteria. Among these, 151 (95.5%) presented metabolic changes, with 94 (62.2%) presenting isolated metabolic change and 57 (37.8%) had mixed changes. The main disorders detected were hypercalciuria (74%), hypocitraturia (37.3%), hyperoxaluria (24.1%), hypomagnesuria (21%), hyperuricosuria (20.2%), primary hyperparathyroidism (1.8%) secondary hyperparathyroidism (0.6%) and renal tubular acidosis (0.6). CONCLUSION: Metabolic change was diagnosed in 95.5% of patients. These results warrant the metabolic study and follow-up in patients with recurrent lithiasis in order to decrease the recurrence rate through specific treatments, modification in alimentary and behavioral habits.UNESP Botucatu Medical School General HospitalState University of São Paulo Institute of Biosciences of BotucatuUNESP Botucatu Medical School General HospitalSociedade Brasileira de UrologiaUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Amaro, Carmen R. [UNESP]Goldberg, José [UNESP]Amaro, João Luiz [UNESP]Padovani, Carlos Roberto [UNESP]2014-05-20T13:33:30Z2014-05-20T13:33:30Z2005-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article29-33application/pdfhttp://dx.doi.org/10.1590/S1677-55382005000100006International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 1, p. 29-33, 2005.1677-5538http://hdl.handle.net/11449/1148110.1590/S1677-55382005000100006S1677-55382005000100006S1677-55382005000100006.pdf8727897080522289SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Braz J Urol0.9760,367info:eu-repo/semantics/openAccess2024-09-03T14:29:55Zoai:repositorio.unesp.br:11449/11481Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:29:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Metabolic assessment in patients with urinary lithiasis
title Metabolic assessment in patients with urinary lithiasis
spellingShingle Metabolic assessment in patients with urinary lithiasis
Amaro, Carmen R. [UNESP]
urolithiasis
risk factors
salts
metabolic disease
follow-up
studies
title_short Metabolic assessment in patients with urinary lithiasis
title_full Metabolic assessment in patients with urinary lithiasis
title_fullStr Metabolic assessment in patients with urinary lithiasis
title_full_unstemmed Metabolic assessment in patients with urinary lithiasis
title_sort Metabolic assessment in patients with urinary lithiasis
author Amaro, Carmen R. [UNESP]
author_facet Amaro, Carmen R. [UNESP]
Goldberg, José [UNESP]
Amaro, João Luiz [UNESP]
Padovani, Carlos Roberto [UNESP]
author_role author
author2 Goldberg, José [UNESP]
Amaro, João Luiz [UNESP]
Padovani, Carlos Roberto [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Amaro, Carmen R. [UNESP]
Goldberg, José [UNESP]
Amaro, João Luiz [UNESP]
Padovani, Carlos Roberto [UNESP]
dc.subject.por.fl_str_mv urolithiasis
risk factors
salts
metabolic disease
follow-up
studies
topic urolithiasis
risk factors
salts
metabolic disease
follow-up
studies
description INTRODUCTION: Metabolic investigation in patients with urinary lithiasis is very important for preventing recurrence of disease. The objective of this work was to diagnose and to determine the prevalence of metabolic disorders, to assess the quality of the water consumed and volume of diuresis as potential risk factors for this pathology. PATIENTS and METHODS: We studied 182 patients older than 12 years. We included patients with history and/or imaging tests confirming at least 2 stones, with creatinine clearance > 60 mL/min and negative urine culture. The protocol consisted in the collection of 2, 24-hour urine samples, for dosing Ca, P, uric acid, Na, K, Mg, Ox and Ci, glycemia and serum levels of Ca, P, Uric acid, Na, K, Cl, Mg, U and Cr, urinary pH and urinary acidification test. RESULTS: 158 patients fulfilled the inclusion criteria. Among these, 151 (95.5%) presented metabolic changes, with 94 (62.2%) presenting isolated metabolic change and 57 (37.8%) had mixed changes. The main disorders detected were hypercalciuria (74%), hypocitraturia (37.3%), hyperoxaluria (24.1%), hypomagnesuria (21%), hyperuricosuria (20.2%), primary hyperparathyroidism (1.8%) secondary hyperparathyroidism (0.6%) and renal tubular acidosis (0.6). CONCLUSION: Metabolic change was diagnosed in 95.5% of patients. These results warrant the metabolic study and follow-up in patients with recurrent lithiasis in order to decrease the recurrence rate through specific treatments, modification in alimentary and behavioral habits.
publishDate 2005
dc.date.none.fl_str_mv 2005-02-01
2014-05-20T13:33:30Z
2014-05-20T13:33:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1677-55382005000100006
International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 1, p. 29-33, 2005.
1677-5538
http://hdl.handle.net/11449/11481
10.1590/S1677-55382005000100006
S1677-55382005000100006
S1677-55382005000100006.pdf
8727897080522289
url http://dx.doi.org/10.1590/S1677-55382005000100006
http://hdl.handle.net/11449/11481
identifier_str_mv International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 1, p. 29-33, 2005.
1677-5538
10.1590/S1677-55382005000100006
S1677-55382005000100006
S1677-55382005000100006.pdf
8727897080522289
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Braz J Urol
0.976
0,367
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 29-33
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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