Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/123942 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/13-05-2015/000825585.pdf |
Resumo: | Objective: to evaluate the effect of isolated vitamin D (VitD) supplementation on the rate of falls and the postural balance in fallers postmenopausal women. Methods: In this double-blind placebo controlled trial 160 women with age 50-65 years, amenorrhea ≥ 12 months and history of falls were included. Participants were allocated at random to receive either 1,000UI VitD /day orally (n = 80) or placebo (n = 80). The intervention time was 9 months, with assessments at initial and final moments. Postural balance was assessed by stabilometry (computerized force platform). Muscle mass was estimated by Total-body DEXA and muscle strength by handgrip strength and chair-rising test. Serum levels of 25-hydroxyvitamin D [25(OH)D] were measured by HPLC. Data were analyzed according to intention-to-treat, using ANOVA, chi-square and logistic regression. Results: After 9 months, mean 25(OH)D levels increased from 15.0±7.5 ng/ml to 27.5±10.4 ng/ml (+45.4%) in the VitD group whereas decreased from 16.9±6.7 ng/ml to 13.8±6.0 ng/ml (-18.5%) in the placebo group (p<.001). The rate of fall was higher in the placebo (+46.3%, p<.001), that presented an adjusted risk of 1.9 (CI 95% 1.23-3.08) times higher of falls and 2.80 (CI 95% 1.43-5.50) times higher of recurrent falls than the VitD group. There was reduction in body sway by stabilometry, with lower amplitude of anteroposterior (-35.5%) and laterolateral (-37.0%) oscillation, only in the VitD group (p<.001). In this group, there was significant increased in muscle strength of the lower limbs by chair-rising test (+45.5%, p=0.036). Women in the placebo group presented significant reduction in the muscle mass (-5.8%) (p=0.030). Conclusion: Fallers postmenopausal women with isolated vitamin D supplementation had a lower rate of falls and improvement in postural balance and muscle strength |
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Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausaMulheresDistúrbios da posturaVitamina DPós-menopausaQuedas (Acidentes)PostmenopauseVitamin DObjective: to evaluate the effect of isolated vitamin D (VitD) supplementation on the rate of falls and the postural balance in fallers postmenopausal women. Methods: In this double-blind placebo controlled trial 160 women with age 50-65 years, amenorrhea ≥ 12 months and history of falls were included. Participants were allocated at random to receive either 1,000UI VitD /day orally (n = 80) or placebo (n = 80). The intervention time was 9 months, with assessments at initial and final moments. Postural balance was assessed by stabilometry (computerized force platform). Muscle mass was estimated by Total-body DEXA and muscle strength by handgrip strength and chair-rising test. Serum levels of 25-hydroxyvitamin D [25(OH)D] were measured by HPLC. Data were analyzed according to intention-to-treat, using ANOVA, chi-square and logistic regression. Results: After 9 months, mean 25(OH)D levels increased from 15.0±7.5 ng/ml to 27.5±10.4 ng/ml (+45.4%) in the VitD group whereas decreased from 16.9±6.7 ng/ml to 13.8±6.0 ng/ml (-18.5%) in the placebo group (p<.001). The rate of fall was higher in the placebo (+46.3%, p<.001), that presented an adjusted risk of 1.9 (CI 95% 1.23-3.08) times higher of falls and 2.80 (CI 95% 1.43-5.50) times higher of recurrent falls than the VitD group. There was reduction in body sway by stabilometry, with lower amplitude of anteroposterior (-35.5%) and laterolateral (-37.0%) oscillation, only in the VitD group (p<.001). In this group, there was significant increased in muscle strength of the lower limbs by chair-rising test (+45.5%, p=0.036). Women in the placebo group presented significant reduction in the muscle mass (-5.8%) (p=0.030). Conclusion: Fallers postmenopausal women with isolated vitamin D supplementation had a lower rate of falls and improvement in postural balance and muscle strengthObjetivo: Avaliar o efeito da suplementação isolada de vitamina D (VD) sobre a ocorrência de quedas e o equilíbrio postural em mulheres na pós-menopausa com histórico de quedas. Métodos: Foi conduzido ensaio clínico, duplo-cego, placebo-controlado envolvendo 160 mulheres, idade 50-65anos, amenorréia ≥12 meses, com histórico de quedas. As participantes foram randomizadas em dois grupos: VD 1000UI/dia via oral (n=80) ou placebo (n=80). O tempo de intervenção foi nove meses, com avaliações nos momentos, inicial e final. Foram avaliados: o equilíbrio pela estabilometria (plataforma de força computadorizada), a massa muscular pela densitometria de corpo total, e a força muscular pelo teste de pressão manual e teste do agachamento. Os valores séricos de 25(OH)D foram mensurados por HPLC. A análise estatística foi por intenção de tratamento (ITT), empregando-se ANOVA, Qui-Quadrado e Regressão Logística. Resultados: Após nove meses, valores médios de 25(OH)D aumentaram de 15,0±7,5 ng/ml para 27,5±10,4 ng/ml (+45.4%) no grupo VD, e diminuíram de 16,9±6,7 ng/ml para 13,8±6,0 ng/ml (-18.5%) no placebo (p<0.001). A ocorrência de quedas foi maior no grupo placebo (+46.3%) com risco ajustado de 1,95 (IC 95% 1,23-3,08) vezes maior de quedas e 2,80 (IC95% 1,43-5,50) vezes maior de quedas recorrentes quando comparado ao grupo VD (p<0.001). Observou-se redução da oscilação corporal pela estabilometria, com menor amplitude ântero-posterior (-35.5%) e latero-lateral (-37.0%) (p<0.001); e aumento da força muscular (+45.5%) pelo teste do agachamento (p=0.036) apenas no grupo VD. Nas mulheres do grupo placebo houve redução (-5.8%) na massa muscular (p=0.030). Conclusão: Em mulheres na pós-menopausa com histórico de quedas, a suplementação isolada de vitamina D repercutiu em menor ocorrência de quedas e melhora no equilíbrio postural e na força muscularCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)CAPES: 75807-3FAPESP: 2009/1444-1Universidade Estadual Paulista (Unesp)Nahás, Eliana Aguiar Petri [UNESP]Nahás Neto, Jorge [UNESP]Universidade Estadual Paulista (Unesp)Oliveira, Luciana Mendes Cangussu [UNESP]2015-06-17T19:34:22Z2015-06-17T19:34:22Z2014-05-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis98 f.application/pdfOLIVEIRA, Luciana Mendes Cangussu. Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa. 2014. 98 f. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, 2014.http://hdl.handle.net/11449/123942000825585http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/13-05-2015/000825585.pdf33004064077P24155170574788417Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2024-09-03T18:42:20Zoai:repositorio.unesp.br:11449/123942Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T18:42:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa |
title |
Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa |
spellingShingle |
Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa Oliveira, Luciana Mendes Cangussu [UNESP] Mulheres Distúrbios da postura Vitamina D Pós-menopausa Quedas (Acidentes) Postmenopause Vitamin D |
title_short |
Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa |
title_full |
Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa |
title_fullStr |
Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa |
title_full_unstemmed |
Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa |
title_sort |
Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa |
author |
Oliveira, Luciana Mendes Cangussu [UNESP] |
author_facet |
Oliveira, Luciana Mendes Cangussu [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Nahás, Eliana Aguiar Petri [UNESP] Nahás Neto, Jorge [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Oliveira, Luciana Mendes Cangussu [UNESP] |
dc.subject.por.fl_str_mv |
Mulheres Distúrbios da postura Vitamina D Pós-menopausa Quedas (Acidentes) Postmenopause Vitamin D |
topic |
Mulheres Distúrbios da postura Vitamina D Pós-menopausa Quedas (Acidentes) Postmenopause Vitamin D |
description |
Objective: to evaluate the effect of isolated vitamin D (VitD) supplementation on the rate of falls and the postural balance in fallers postmenopausal women. Methods: In this double-blind placebo controlled trial 160 women with age 50-65 years, amenorrhea ≥ 12 months and history of falls were included. Participants were allocated at random to receive either 1,000UI VitD /day orally (n = 80) or placebo (n = 80). The intervention time was 9 months, with assessments at initial and final moments. Postural balance was assessed by stabilometry (computerized force platform). Muscle mass was estimated by Total-body DEXA and muscle strength by handgrip strength and chair-rising test. Serum levels of 25-hydroxyvitamin D [25(OH)D] were measured by HPLC. Data were analyzed according to intention-to-treat, using ANOVA, chi-square and logistic regression. Results: After 9 months, mean 25(OH)D levels increased from 15.0±7.5 ng/ml to 27.5±10.4 ng/ml (+45.4%) in the VitD group whereas decreased from 16.9±6.7 ng/ml to 13.8±6.0 ng/ml (-18.5%) in the placebo group (p<.001). The rate of fall was higher in the placebo (+46.3%, p<.001), that presented an adjusted risk of 1.9 (CI 95% 1.23-3.08) times higher of falls and 2.80 (CI 95% 1.43-5.50) times higher of recurrent falls than the VitD group. There was reduction in body sway by stabilometry, with lower amplitude of anteroposterior (-35.5%) and laterolateral (-37.0%) oscillation, only in the VitD group (p<.001). In this group, there was significant increased in muscle strength of the lower limbs by chair-rising test (+45.5%, p=0.036). Women in the placebo group presented significant reduction in the muscle mass (-5.8%) (p=0.030). Conclusion: Fallers postmenopausal women with isolated vitamin D supplementation had a lower rate of falls and improvement in postural balance and muscle strength |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-05-22 2015-06-17T19:34:22Z 2015-06-17T19:34:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
OLIVEIRA, Luciana Mendes Cangussu. Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa. 2014. 98 f. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, 2014. http://hdl.handle.net/11449/123942 000825585 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/13-05-2015/000825585.pdf 33004064077P2 4155170574788417 |
identifier_str_mv |
OLIVEIRA, Luciana Mendes Cangussu. Efeito da vitamina D sobre o equilíbrio postural em mulheres na pós-menopausa. 2014. 98 f. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, 2014. 000825585 33004064077P2 4155170574788417 |
url |
http://hdl.handle.net/11449/123942 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/13-05-2015/000825585.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
98 f. application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
Aleph reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021425491214336 |