Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2009/432493 http://hdl.handle.net/11449/17510 |
Resumo: | The present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, which peaked on day 26. The number of mast cells, probably immature, was ten times higher on day 8. Different from animals infected with intestinal parasites, after colitis remission, mast cells do not migrate to the spleen, showing that mast cell proliferation presents different characteristics depending on the inflammation stimuli. Treatment with sulfasalazine, doxantrazole, quercetin, or nedocromil did not increase the histamine concentration or the mast cell number in the colon on day 26, thereby showing absence of degranulation of these cells. In conclusion, although mast cell proliferation is associated with colitis, these cells and their mediators appear to play no clear role in the colitis with relapses. Copyright (C) 2009 Ana Carolina Luchini et al. |
id |
UNSP_c325a2a0e1ff3327530fd915fa8100c2 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/17510 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar RatsThe present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, which peaked on day 26. The number of mast cells, probably immature, was ten times higher on day 8. Different from animals infected with intestinal parasites, after colitis remission, mast cells do not migrate to the spleen, showing that mast cell proliferation presents different characteristics depending on the inflammation stimuli. Treatment with sulfasalazine, doxantrazole, quercetin, or nedocromil did not increase the histamine concentration or the mast cell number in the colon on day 26, thereby showing absence of degranulation of these cells. In conclusion, although mast cell proliferation is associated with colitis, these cells and their mediators appear to play no clear role in the colitis with relapses. Copyright (C) 2009 Ana Carolina Luchini et al.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNESP, Dept Pharmacol, Inst Biosci, BR-18618000 Botucatu, SP, BrazilUNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, BrazilUNESP, Dept Pharmacol, Inst Biosci, BR-18618000 Botucatu, SP, BrazilUNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Luchini, Ana Carolina [UNESP]Costa de Oliveira, Deborah Mara [UNESP]Pellizzon, Claudia Helena [UNESP]Di Stasi, Luiz Claudio [UNESP]Gomes, Jose Carlos [UNESP]2014-05-20T13:49:11Z2014-05-20T13:49:11Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1155/2009/432493Mediators of Inflammation. New York: Hindawi Publishing Corporation, p. 7, 2009.0962-9351http://hdl.handle.net/11449/1751010.1155/2009/432493WOS:000266378000001WOS000266378000001.pdf001939377980106916975473250964570000-0002-4494-4180Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediators of Inflammation3.5491,370info:eu-repo/semantics/openAccess2023-12-09T06:19:03Zoai:repositorio.unesp.br:11449/17510Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:50:29.614751Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
title |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
spellingShingle |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats Luchini, Ana Carolina [UNESP] |
title_short |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
title_full |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
title_fullStr |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
title_full_unstemmed |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
title_sort |
Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
author |
Luchini, Ana Carolina [UNESP] |
author_facet |
Luchini, Ana Carolina [UNESP] Costa de Oliveira, Deborah Mara [UNESP] Pellizzon, Claudia Helena [UNESP] Di Stasi, Luiz Claudio [UNESP] Gomes, Jose Carlos [UNESP] |
author_role |
author |
author2 |
Costa de Oliveira, Deborah Mara [UNESP] Pellizzon, Claudia Helena [UNESP] Di Stasi, Luiz Claudio [UNESP] Gomes, Jose Carlos [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Luchini, Ana Carolina [UNESP] Costa de Oliveira, Deborah Mara [UNESP] Pellizzon, Claudia Helena [UNESP] Di Stasi, Luiz Claudio [UNESP] Gomes, Jose Carlos [UNESP] |
description |
The present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, which peaked on day 26. The number of mast cells, probably immature, was ten times higher on day 8. Different from animals infected with intestinal parasites, after colitis remission, mast cells do not migrate to the spleen, showing that mast cell proliferation presents different characteristics depending on the inflammation stimuli. Treatment with sulfasalazine, doxantrazole, quercetin, or nedocromil did not increase the histamine concentration or the mast cell number in the colon on day 26, thereby showing absence of degranulation of these cells. In conclusion, although mast cell proliferation is associated with colitis, these cells and their mediators appear to play no clear role in the colitis with relapses. Copyright (C) 2009 Ana Carolina Luchini et al. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2014-05-20T13:49:11Z 2014-05-20T13:49:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2009/432493 Mediators of Inflammation. New York: Hindawi Publishing Corporation, p. 7, 2009. 0962-9351 http://hdl.handle.net/11449/17510 10.1155/2009/432493 WOS:000266378000001 WOS000266378000001.pdf 0019393779801069 1697547325096457 0000-0002-4494-4180 |
url |
http://dx.doi.org/10.1155/2009/432493 http://hdl.handle.net/11449/17510 |
identifier_str_mv |
Mediators of Inflammation. New York: Hindawi Publishing Corporation, p. 7, 2009. 0962-9351 10.1155/2009/432493 WOS:000266378000001 WOS000266378000001.pdf 0019393779801069 1697547325096457 0000-0002-4494-4180 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mediators of Inflammation 3.549 1,370 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129127324057600 |