Multiparticulate systems of pectin-chitosan: Study of swelling and drug release
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.latamjpharm.org/trabajos/25/4/LAJOP_25_4_1_9_J920J3570X.pdf http://hdl.handle.net/11449/69151 |
Resumo: | The aim of this study was to prepare multiparticulate systems of pectin:chitosan (PC:CS) and to evaluate their swelling ratio and the drug release in different environments. PC:CS particles containing triamcinolone were prepared by a complex coacervation/ionotropic gelation method in aqueous environment. The polymer ratio, the calcium concentration and the contact time of the capsules with chitosan dispersion for particles formation and the structures obtained were analyzed. The systems were characterized in relation to morphology, size, swelling, and drug release behavior. The methodology used allowed the production of spherical particles with narrow range of size distribution. The entrapment efficiency for triamcinolone was 84.31 ± 439. It was observed that the particles present a relatively low swelling ratio in acidic medium and a larger swelling ratio in enteric medium. The release profile was dependent on pH and can be related with the swelling ratio. |
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Multiparticulate systems of pectin-chitosan: Study of swelling and drug releaseChitosanMultiparticulate systemsPectinSwellingTriamcinolonecalciumchitosanpectintriamcinolonecoacervationdispersiondrug capsuledrug releasedrug synthesisgelationparticle sizepH measurementThe aim of this study was to prepare multiparticulate systems of pectin:chitosan (PC:CS) and to evaluate their swelling ratio and the drug release in different environments. PC:CS particles containing triamcinolone were prepared by a complex coacervation/ionotropic gelation method in aqueous environment. The polymer ratio, the calcium concentration and the contact time of the capsules with chitosan dispersion for particles formation and the structures obtained were analyzed. The systems were characterized in relation to morphology, size, swelling, and drug release behavior. The methodology used allowed the production of spherical particles with narrow range of size distribution. The entrapment efficiency for triamcinolone was 84.31 ± 439. It was observed that the particles present a relatively low swelling ratio in acidic medium and a larger swelling ratio in enteric medium. The release profile was dependent on pH and can be related with the swelling ratio.Univesidade Estadual Paulista Júlio de Mesquita Filho - UNESP Faculdade de Ciências Farmacêuticas Programa de Pós-graduação em Ciências Farmacêuticas, 14.801-902 - Araraquara - SPUniversidade do Vale do Itajaí Centro de Ciências da Saúde NIQFAR, 88.302-202 - Itajaí- SCUnivesidade Estadual Paulista Júlio de Mesquita Filho - UNESP Faculdade de Ciências Farmacêuticas Programa de Pós-graduação em Ciências Farmacêuticas, 14.801-902 - Araraquara - SPUniversidade Estadual Paulista (Unesp)NIQFARLucinda-Silva, Ruth Meri [UNESP]Monteiro, Karen Cristina Moutinho [UNESP]Carvalho, Lívia de Queiróz [UNESP]Evangelista, Raul Cesar [UNESP]2014-05-27T11:22:00Z2014-05-27T11:22:00Z2006-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article538-543http://www.latamjpharm.org/trabajos/25/4/LAJOP_25_4_1_9_J920J3570X.pdfActa Farmaceutica Bonaerense, v. 25, n. 4, p. 538-543, 2006.0326-2383http://hdl.handle.net/11449/691512-s2.0-339476543115361569184579557Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Farmaceutica Bonaerense0.4010,152info:eu-repo/semantics/openAccess2021-10-23T10:48:53Zoai:repositorio.unesp.br:11449/69151Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T10:48:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Multiparticulate systems of pectin-chitosan: Study of swelling and drug release |
title |
Multiparticulate systems of pectin-chitosan: Study of swelling and drug release |
spellingShingle |
Multiparticulate systems of pectin-chitosan: Study of swelling and drug release Lucinda-Silva, Ruth Meri [UNESP] Chitosan Multiparticulate systems Pectin Swelling Triamcinolone calcium chitosan pectin triamcinolone coacervation dispersion drug capsule drug release drug synthesis gelation particle size pH measurement |
title_short |
Multiparticulate systems of pectin-chitosan: Study of swelling and drug release |
title_full |
Multiparticulate systems of pectin-chitosan: Study of swelling and drug release |
title_fullStr |
Multiparticulate systems of pectin-chitosan: Study of swelling and drug release |
title_full_unstemmed |
Multiparticulate systems of pectin-chitosan: Study of swelling and drug release |
title_sort |
Multiparticulate systems of pectin-chitosan: Study of swelling and drug release |
author |
Lucinda-Silva, Ruth Meri [UNESP] |
author_facet |
Lucinda-Silva, Ruth Meri [UNESP] Monteiro, Karen Cristina Moutinho [UNESP] Carvalho, Lívia de Queiróz [UNESP] Evangelista, Raul Cesar [UNESP] |
author_role |
author |
author2 |
Monteiro, Karen Cristina Moutinho [UNESP] Carvalho, Lívia de Queiróz [UNESP] Evangelista, Raul Cesar [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) NIQFAR |
dc.contributor.author.fl_str_mv |
Lucinda-Silva, Ruth Meri [UNESP] Monteiro, Karen Cristina Moutinho [UNESP] Carvalho, Lívia de Queiróz [UNESP] Evangelista, Raul Cesar [UNESP] |
dc.subject.por.fl_str_mv |
Chitosan Multiparticulate systems Pectin Swelling Triamcinolone calcium chitosan pectin triamcinolone coacervation dispersion drug capsule drug release drug synthesis gelation particle size pH measurement |
topic |
Chitosan Multiparticulate systems Pectin Swelling Triamcinolone calcium chitosan pectin triamcinolone coacervation dispersion drug capsule drug release drug synthesis gelation particle size pH measurement |
description |
The aim of this study was to prepare multiparticulate systems of pectin:chitosan (PC:CS) and to evaluate their swelling ratio and the drug release in different environments. PC:CS particles containing triamcinolone were prepared by a complex coacervation/ionotropic gelation method in aqueous environment. The polymer ratio, the calcium concentration and the contact time of the capsules with chitosan dispersion for particles formation and the structures obtained were analyzed. The systems were characterized in relation to morphology, size, swelling, and drug release behavior. The methodology used allowed the production of spherical particles with narrow range of size distribution. The entrapment efficiency for triamcinolone was 84.31 ± 439. It was observed that the particles present a relatively low swelling ratio in acidic medium and a larger swelling ratio in enteric medium. The release profile was dependent on pH and can be related with the swelling ratio. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10-01 2014-05-27T11:22:00Z 2014-05-27T11:22:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.latamjpharm.org/trabajos/25/4/LAJOP_25_4_1_9_J920J3570X.pdf Acta Farmaceutica Bonaerense, v. 25, n. 4, p. 538-543, 2006. 0326-2383 http://hdl.handle.net/11449/69151 2-s2.0-33947654311 5361569184579557 |
url |
http://www.latamjpharm.org/trabajos/25/4/LAJOP_25_4_1_9_J920J3570X.pdf http://hdl.handle.net/11449/69151 |
identifier_str_mv |
Acta Farmaceutica Bonaerense, v. 25, n. 4, p. 538-543, 2006. 0326-2383 2-s2.0-33947654311 5361569184579557 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Farmaceutica Bonaerense 0.401 0,152 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
538-543 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965431037952000 |