Estudo do efeito de lesões seletivas no grupamento noradrenérgico A5 no reflexo auditivo de sobressalto e na inibição por estímulo prévio

• Autor(a) principal: Ferreira, Michelle de Souza [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/145407; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2016-09-20/000869683.pdf
• topic: Norepinefrina; Neurorreguladores; Neuronios; Reflexo de sobressalto; Coclea; Tronco encefalico; Locus Cerúleo; Reflex, Startle; Locus coeruleus

The cochlear root neurons are the first neurons of the central nervous system to receive auditory information from the cochlea and connect with sensorimotor integration centers of the brainstem, in particular the reticular pontine caudal nucleus. Functionally, the cochlear root neurons are involved in elementary circuit of the acoustic startle reflex, which is composed by the ganglion cells of the organ of Corti, the reticular pontine caudal nucleus and the motor neurons of the spinal cord. The acoustic startle reflex presents a series of modulations such as habituation, sensitization, prepulse inhibition and potentiation by an adverse stimulus. Changes in reflex reaction and in its different modulations have diagnostic value in the clinic of neurodegenerative and psychiatric diseases such as Parkinson's and schizophrenia. The modulations of the acoustic startle reflex occur by the influence overnuclei of the elementary circuit of this reflex. The nucleus least studied in the startle reflex neural circuit is the cochlear root nucleus. The pattern of efferent connectivity of the cochlear root neurons is well known but little is known about the origins of their afferent and the neurochemical identity of that. Previous studies have demonstrated that dendrites and soma of the neurons of the cochlear root synaptic buttons are covered by the four types suggesting that there are several sources for these axon terminals, with its own neurochemical characteristics. Recent experiments in our research group identified afferents to CRN from two important noradrenergic regions of the brainstem: the noradrenergic group A5 (A5) and the locus coeruleus (LC). However for the A5 grouping there are no behavioral studies on functional aspects of this connection. Furthermore, in order to determine the involvement of neuropeptide modulation of the RAS, there are reports in the literature on co-existence with the transcript of noradrenaline and neuropeptide regulated...