Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1053/j.tcam.2017.05.007 http://hdl.handle.net/11449/174680 |
Resumo: | Pure red cell aplasia (PRCA) is a disorder that leads to a nonregenerative anemia that results from erythroid precursors failing to reach maturity in the bone marrow, whereas the numbers of mature myeloid and megakaryocytic cells remain normal. PRCA can be induced by autoimmune processes, infections, drugs, toxins, and radiation, and is diagnosed by a bone marrow cytology examination after excluding the most common causes of nonregenerative anemia. Immunosuppressive therapies are used to treat PRCA, and usually involve the use of glucocorticoids, cyclosporin, or azathioprine. Alternatively, although little studied in veterinary medicine, drugs which stimulate bone marrow (e.g., nandrolone decanoate) have been mentioned as possible therapeutic agents. A case of PRCA that presented at the Veterinary Teaching Hospital of the Faculty of Veterinary Medicine and Animal Science (UNESP)—Botucatu, Brazil showed a good therapeutic response to weekly administration of nandrolone decanoate. Therefore, it was concluded that bone marrow stimulants might improve the quality of life of PRCA patients, provided they are used with caution and under close clinical supervision. |
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Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Reportaplasiadogsimmune-mediated hemolytic anemianandrolone decanoatePure red cell aplasia (PRCA) is a disorder that leads to a nonregenerative anemia that results from erythroid precursors failing to reach maturity in the bone marrow, whereas the numbers of mature myeloid and megakaryocytic cells remain normal. PRCA can be induced by autoimmune processes, infections, drugs, toxins, and radiation, and is diagnosed by a bone marrow cytology examination after excluding the most common causes of nonregenerative anemia. Immunosuppressive therapies are used to treat PRCA, and usually involve the use of glucocorticoids, cyclosporin, or azathioprine. Alternatively, although little studied in veterinary medicine, drugs which stimulate bone marrow (e.g., nandrolone decanoate) have been mentioned as possible therapeutic agents. A case of PRCA that presented at the Veterinary Teaching Hospital of the Faculty of Veterinary Medicine and Animal Science (UNESP)—Botucatu, Brazil showed a good therapeutic response to weekly administration of nandrolone decanoate. Therefore, it was concluded that bone marrow stimulants might improve the quality of life of PRCA patients, provided they are used with caution and under close clinical supervision.Veterinary Clinic Department School of Veterinary Medicine and Animal Science São Paulo State University—UNESPPhysics and Biophysics Department Institute of Bioscience São Paulo State University—UNESPVeterinary Clinic Department School of Veterinary Medicine and Animal Science São Paulo State University—UNESPPhysics and Biophysics Department Institute of Bioscience São Paulo State University—UNESPUniversidade Estadual Paulista (Unesp)de Marchi, Paula Nassar [UNESP]Sueur Vieira, André Nanny Le [UNESP]Antunes Ribeiro, José Francisco [UNESP]Geraldes, Silvano Salgueiro [UNESP]Rodrigues Ramos, Paulo Roberto [UNESP]Melchert, Alessandra [UNESP]Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]2018-12-11T17:12:24Z2018-12-11T17:12:24Z2017-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article44-47application/pdfhttp://dx.doi.org/10.1053/j.tcam.2017.05.007Topics in Companion Animal Medicine, v. 32, n. 1, p. 44-47, 2017.1938-9736http://hdl.handle.net/11449/17468010.1053/j.tcam.2017.05.0072-s2.0-850200226622-s2.0-85020022662.pdf50854849802141250000-0003-1944-2426Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTopics in Companion Animal Medicine0,384info:eu-repo/semantics/openAccess2024-01-15T06:21:57Zoai:repositorio.unesp.br:11449/174680Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:03:50.799246Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report |
title |
Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report |
spellingShingle |
Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report de Marchi, Paula Nassar [UNESP] aplasia dogs immune-mediated hemolytic anemia nandrolone decanoate |
title_short |
Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report |
title_full |
Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report |
title_fullStr |
Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report |
title_full_unstemmed |
Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report |
title_sort |
Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report |
author |
de Marchi, Paula Nassar [UNESP] |
author_facet |
de Marchi, Paula Nassar [UNESP] Sueur Vieira, André Nanny Le [UNESP] Antunes Ribeiro, José Francisco [UNESP] Geraldes, Silvano Salgueiro [UNESP] Rodrigues Ramos, Paulo Roberto [UNESP] Melchert, Alessandra [UNESP] Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
author_role |
author |
author2 |
Sueur Vieira, André Nanny Le [UNESP] Antunes Ribeiro, José Francisco [UNESP] Geraldes, Silvano Salgueiro [UNESP] Rodrigues Ramos, Paulo Roberto [UNESP] Melchert, Alessandra [UNESP] Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Marchi, Paula Nassar [UNESP] Sueur Vieira, André Nanny Le [UNESP] Antunes Ribeiro, José Francisco [UNESP] Geraldes, Silvano Salgueiro [UNESP] Rodrigues Ramos, Paulo Roberto [UNESP] Melchert, Alessandra [UNESP] Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
dc.subject.por.fl_str_mv |
aplasia dogs immune-mediated hemolytic anemia nandrolone decanoate |
topic |
aplasia dogs immune-mediated hemolytic anemia nandrolone decanoate |
description |
Pure red cell aplasia (PRCA) is a disorder that leads to a nonregenerative anemia that results from erythroid precursors failing to reach maturity in the bone marrow, whereas the numbers of mature myeloid and megakaryocytic cells remain normal. PRCA can be induced by autoimmune processes, infections, drugs, toxins, and radiation, and is diagnosed by a bone marrow cytology examination after excluding the most common causes of nonregenerative anemia. Immunosuppressive therapies are used to treat PRCA, and usually involve the use of glucocorticoids, cyclosporin, or azathioprine. Alternatively, although little studied in veterinary medicine, drugs which stimulate bone marrow (e.g., nandrolone decanoate) have been mentioned as possible therapeutic agents. A case of PRCA that presented at the Veterinary Teaching Hospital of the Faculty of Veterinary Medicine and Animal Science (UNESP)—Botucatu, Brazil showed a good therapeutic response to weekly administration of nandrolone decanoate. Therefore, it was concluded that bone marrow stimulants might improve the quality of life of PRCA patients, provided they are used with caution and under close clinical supervision. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 2018-12-11T17:12:24Z 2018-12-11T17:12:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1053/j.tcam.2017.05.007 Topics in Companion Animal Medicine, v. 32, n. 1, p. 44-47, 2017. 1938-9736 http://hdl.handle.net/11449/174680 10.1053/j.tcam.2017.05.007 2-s2.0-85020022662 2-s2.0-85020022662.pdf 5085484980214125 0000-0003-1944-2426 |
url |
http://dx.doi.org/10.1053/j.tcam.2017.05.007 http://hdl.handle.net/11449/174680 |
identifier_str_mv |
Topics in Companion Animal Medicine, v. 32, n. 1, p. 44-47, 2017. 1938-9736 10.1053/j.tcam.2017.05.007 2-s2.0-85020022662 2-s2.0-85020022662.pdf 5085484980214125 0000-0003-1944-2426 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Topics in Companion Animal Medicine 0,384 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
44-47 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129485942292480 |