Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1128/IAI.00476-17 http://hdl.handle.net/11449/170374 |
Resumo: | Intestinal bacteria employ microbial metabolites from the microbiota and chemical signaling during cell-to-cell communication to regulate several cellular functions. Pathogenic bacteria are extremely efficient in orchestrating their response to these signals through complex signaling transduction systems. Precise coordination and interpretation of these multiple chemical cues is important within the gastrointestinal (GI) tract. Enteric foodborne pathogens, such as enterohemorrhagic Escherichia coli (EHEC) and Salmonella enterica serovar Typhimurium, or the surrogate murine infection model for EHEC, Citrobacter rodentium, are all examples of microorganisms that modulate the expression of their virulence repertoire in response to signals from the microbiota or the host, such as autoinducer-3 (AI-3), epinephrine (Epi), and norepinephrine (NE). The QseBC and QseEF two-component systems, shared by these pathogens, are involved in sensing these signals. We review how these signaling systems sense and relay these signals to drive bacterial gene expression; specifically, to modulate virulence. We also review how bacteria chat via chemical signals integrated with metabolite recognition and utilization to promote successful associations among enteric pathogens, the microbiota, and the host. |
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Repositório Institucional da UNESP |
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Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactionsChemical signalingEnterobacteriaceaeEscherichiaIntestinal metabolitesSalmonellaIntestinal bacteria employ microbial metabolites from the microbiota and chemical signaling during cell-to-cell communication to regulate several cellular functions. Pathogenic bacteria are extremely efficient in orchestrating their response to these signals through complex signaling transduction systems. Precise coordination and interpretation of these multiple chemical cues is important within the gastrointestinal (GI) tract. Enteric foodborne pathogens, such as enterohemorrhagic Escherichia coli (EHEC) and Salmonella enterica serovar Typhimurium, or the surrogate murine infection model for EHEC, Citrobacter rodentium, are all examples of microorganisms that modulate the expression of their virulence repertoire in response to signals from the microbiota or the host, such as autoinducer-3 (AI-3), epinephrine (Epi), and norepinephrine (NE). The QseBC and QseEF two-component systems, shared by these pathogens, are involved in sensing these signals. We review how these signaling systems sense and relay these signals to drive bacterial gene expression; specifically, to modulate virulence. We also review how bacteria chat via chemical signals integrated with metabolite recognition and utilization to promote successful associations among enteric pathogens, the microbiota, and the host.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Biological Sciences São Paulo State University UNESPDepartments of Microbiology and Biochemistry University of Texas Southwestern Medical CenterDepartment of Biological Sciences São Paulo State University UNESPCNPq: 441884/2014-8Universidade Estadual Paulista (Unesp)University of Texas Southwestern Medical CenterLustri, Bruna C. [UNESP]Sperandio, VanessaMoreira, Cristiano G. [UNESP]2018-12-11T16:50:32Z2018-12-11T16:50:32Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1128/IAI.00476-17Infection and Immunity, v. 85, n. 12, 2017.1098-55220019-9567http://hdl.handle.net/11449/17037410.1128/IAI.00476-172-s2.0-850340181162-s2.0-85034018116.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInfection and Immunity1,9541,954info:eu-repo/semantics/openAccess2023-12-04T06:11:57Zoai:repositorio.unesp.br:11449/170374Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-04T06:11:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions |
title |
Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions |
spellingShingle |
Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions Lustri, Bruna C. [UNESP] Chemical signaling Enterobacteriaceae Escherichia Intestinal metabolites Salmonella |
title_short |
Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions |
title_full |
Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions |
title_fullStr |
Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions |
title_full_unstemmed |
Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions |
title_sort |
Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions |
author |
Lustri, Bruna C. [UNESP] |
author_facet |
Lustri, Bruna C. [UNESP] Sperandio, Vanessa Moreira, Cristiano G. [UNESP] |
author_role |
author |
author2 |
Sperandio, Vanessa Moreira, Cristiano G. [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Texas Southwestern Medical Center |
dc.contributor.author.fl_str_mv |
Lustri, Bruna C. [UNESP] Sperandio, Vanessa Moreira, Cristiano G. [UNESP] |
dc.subject.por.fl_str_mv |
Chemical signaling Enterobacteriaceae Escherichia Intestinal metabolites Salmonella |
topic |
Chemical signaling Enterobacteriaceae Escherichia Intestinal metabolites Salmonella |
description |
Intestinal bacteria employ microbial metabolites from the microbiota and chemical signaling during cell-to-cell communication to regulate several cellular functions. Pathogenic bacteria are extremely efficient in orchestrating their response to these signals through complex signaling transduction systems. Precise coordination and interpretation of these multiple chemical cues is important within the gastrointestinal (GI) tract. Enteric foodborne pathogens, such as enterohemorrhagic Escherichia coli (EHEC) and Salmonella enterica serovar Typhimurium, or the surrogate murine infection model for EHEC, Citrobacter rodentium, are all examples of microorganisms that modulate the expression of their virulence repertoire in response to signals from the microbiota or the host, such as autoinducer-3 (AI-3), epinephrine (Epi), and norepinephrine (NE). The QseBC and QseEF two-component systems, shared by these pathogens, are involved in sensing these signals. We review how these signaling systems sense and relay these signals to drive bacterial gene expression; specifically, to modulate virulence. We also review how bacteria chat via chemical signals integrated with metabolite recognition and utilization to promote successful associations among enteric pathogens, the microbiota, and the host. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T16:50:32Z 2018-12-11T16:50:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1128/IAI.00476-17 Infection and Immunity, v. 85, n. 12, 2017. 1098-5522 0019-9567 http://hdl.handle.net/11449/170374 10.1128/IAI.00476-17 2-s2.0-85034018116 2-s2.0-85034018116.pdf |
url |
http://dx.doi.org/10.1128/IAI.00476-17 http://hdl.handle.net/11449/170374 |
identifier_str_mv |
Infection and Immunity, v. 85, n. 12, 2017. 1098-5522 0019-9567 10.1128/IAI.00476-17 2-s2.0-85034018116 2-s2.0-85034018116.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Infection and Immunity 1,954 1,954 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046788867817472 |