5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus)
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.neulet.2010.10.070 http://hdl.handle.net/11449/10813 |
Resumo: | Serotonin (5-HT) is involved in the fine adjustments at several brain centers including the core of the mammal circadian timing system (CTS) and the hypothalamic suprachiasmatic nucleus (SCN). The SCN receives massive serotonergic projections from the midbrain raphe nuclei, whose inputs are described in rats as ramifying at its ventral portion overlapping the retinohypothalamic and geniculohypothalamic fibers. In the SCN, the 5-HT actions are reported as being primarily mediated by the 5-HT1 type receptor with noted emphasis for 5-HT1B subtype, supposedly modulating the retinal input in a presynaptic way. In this study in a New World primate species, the common marmoset (Callithrix jacchus), we showed the 5-HT1B receptor distribution at the dorsal SCN concurrent with a distinctive location of 5-HT-immunoreactive fibers. This finding addresses to a new discussion on the regulation and synchronization of the circadian rhythms in recent primates. (C) 2010 Elsevier B.V. All rights reserved. |
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Repositório Institucional da UNESP |
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5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus)Suprachiasmatic nucleusSerotonin receptorCallithrix jacchusPrimateCircadian timing systemSerotoninSerotonin (5-HT) is involved in the fine adjustments at several brain centers including the core of the mammal circadian timing system (CTS) and the hypothalamic suprachiasmatic nucleus (SCN). The SCN receives massive serotonergic projections from the midbrain raphe nuclei, whose inputs are described in rats as ramifying at its ventral portion overlapping the retinohypothalamic and geniculohypothalamic fibers. In the SCN, the 5-HT actions are reported as being primarily mediated by the 5-HT1 type receptor with noted emphasis for 5-HT1B subtype, supposedly modulating the retinal input in a presynaptic way. In this study in a New World primate species, the common marmoset (Callithrix jacchus), we showed the 5-HT1B receptor distribution at the dorsal SCN concurrent with a distinctive location of 5-HT-immunoreactive fibers. This finding addresses to a new discussion on the regulation and synchronization of the circadian rhythms in recent primates. (C) 2010 Elsevier B.V. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)PROPESQ-UFRNFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal do Rio Grande do Norte (UFRN), Dept Physiol, Biosci Ctr, Lab Chronobiol, BR-59072970 Natal, RN, BrazilSão Paulo State Univ, Speech Language & Hearing Therapy Dept, BR-17525900 Marilia, SP, BrazilCity Univ São Paulo, Neurosci Lab, BR-03071000 São Paulo, BrazilSão Paulo State Univ, Speech Language & Hearing Therapy Dept, BR-17525900 Marilia, SP, BrazilElsevier B.V.Universidade Federal do Rio Grande do Norte (UFRN)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Cavalcante, Jeferson S.de Pontes, Andre L. B.Engelberth, Rovena C. G. J.Cavalcante, Judney C.Nascimento, Expedito S.Borda, Janaina S.Pinato, Luciana [UNESP]Costa, Miriam S. M. O.de Toledo, Claudio A. B.2014-05-20T13:31:45Z2014-05-20T13:31:45Z2011-01-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article06/outapplication/pdfhttp://dx.doi.org/10.1016/j.neulet.2010.10.070Neuroscience Letters. Clare: Elsevier B.V., v. 488, n. 1, p. 6-10, 2011.0304-3940http://hdl.handle.net/11449/1081310.1016/j.neulet.2010.10.070WOS:000286997800002WOS000286997800002.pdf8372363591179624Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNeuroscience Letters2.1590,946info:eu-repo/semantics/openAccess2023-12-15T06:15:04Zoai:repositorio.unesp.br:11449/10813Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-15T06:15:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus) |
title |
5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus) |
spellingShingle |
5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus) Cavalcante, Jeferson S. Suprachiasmatic nucleus Serotonin receptor Callithrix jacchus Primate Circadian timing system Serotonin |
title_short |
5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus) |
title_full |
5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus) |
title_fullStr |
5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus) |
title_full_unstemmed |
5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus) |
title_sort |
5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus) |
author |
Cavalcante, Jeferson S. |
author_facet |
Cavalcante, Jeferson S. de Pontes, Andre L. B. Engelberth, Rovena C. G. J. Cavalcante, Judney C. Nascimento, Expedito S. Borda, Janaina S. Pinato, Luciana [UNESP] Costa, Miriam S. M. O. de Toledo, Claudio A. B. |
author_role |
author |
author2 |
de Pontes, Andre L. B. Engelberth, Rovena C. G. J. Cavalcante, Judney C. Nascimento, Expedito S. Borda, Janaina S. Pinato, Luciana [UNESP] Costa, Miriam S. M. O. de Toledo, Claudio A. B. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte (UFRN) Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Cavalcante, Jeferson S. de Pontes, Andre L. B. Engelberth, Rovena C. G. J. Cavalcante, Judney C. Nascimento, Expedito S. Borda, Janaina S. Pinato, Luciana [UNESP] Costa, Miriam S. M. O. de Toledo, Claudio A. B. |
dc.subject.por.fl_str_mv |
Suprachiasmatic nucleus Serotonin receptor Callithrix jacchus Primate Circadian timing system Serotonin |
topic |
Suprachiasmatic nucleus Serotonin receptor Callithrix jacchus Primate Circadian timing system Serotonin |
description |
Serotonin (5-HT) is involved in the fine adjustments at several brain centers including the core of the mammal circadian timing system (CTS) and the hypothalamic suprachiasmatic nucleus (SCN). The SCN receives massive serotonergic projections from the midbrain raphe nuclei, whose inputs are described in rats as ramifying at its ventral portion overlapping the retinohypothalamic and geniculohypothalamic fibers. In the SCN, the 5-HT actions are reported as being primarily mediated by the 5-HT1 type receptor with noted emphasis for 5-HT1B subtype, supposedly modulating the retinal input in a presynaptic way. In this study in a New World primate species, the common marmoset (Callithrix jacchus), we showed the 5-HT1B receptor distribution at the dorsal SCN concurrent with a distinctive location of 5-HT-immunoreactive fibers. This finding addresses to a new discussion on the regulation and synchronization of the circadian rhythms in recent primates. (C) 2010 Elsevier B.V. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-13 2014-05-20T13:31:45Z 2014-05-20T13:31:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.neulet.2010.10.070 Neuroscience Letters. Clare: Elsevier B.V., v. 488, n. 1, p. 6-10, 2011. 0304-3940 http://hdl.handle.net/11449/10813 10.1016/j.neulet.2010.10.070 WOS:000286997800002 WOS000286997800002.pdf 8372363591179624 |
url |
http://dx.doi.org/10.1016/j.neulet.2010.10.070 http://hdl.handle.net/11449/10813 |
identifier_str_mv |
Neuroscience Letters. Clare: Elsevier B.V., v. 488, n. 1, p. 6-10, 2011. 0304-3940 10.1016/j.neulet.2010.10.070 WOS:000286997800002 WOS000286997800002.pdf 8372363591179624 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neuroscience Letters 2.159 0,946 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
06/out application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965290130309120 |