The green tea molecule EGCG inhibits Zika virus entry

Detalhes bibliográficos
Autor(a) principal: Carneiro, Bruno M. [UNESP]
Data de Publicação: 2016
Outros Autores: Batista, Mariana N. [UNESP], Braga, Ana Cláudia S. [UNESP], Nogueira, Maurício L., Rahal, Paula [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.virol.2016.06.012
http://hdl.handle.net/11449/178090
Resumo: During ZIKV the outbreak in Brazil it was observed an increase of almost 20 times the number of reported cases of microcephaly in newborn babies. There is no vaccine or approved drug available for the treatment and prevention of infections by this virus. EGCG, a polyphenol present in green tea has been shown to have an antiviral activity for many viruses. In view of the need for the development of a drug against a Brazilian strain of ZIKV, we assessed the effect of EGCG on ZIKV entry in Vero E6 cells. The drug was capable of inhibiting the virus entry by at least 1-log (>90%) at higher concentrations (>100 μM). The pre-treatment of cells with EGCG did not show any effect on virus attachment. This is the first study to demonstrate the effect of EGCG on ZIKV indicating that this drug might be possibility to be used for prevention of Zika virus infections.
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spelling The green tea molecule EGCG inhibits Zika virus entry(-)-Epigallocatechin gallateAntiviralGreen-teaZika virusDuring ZIKV the outbreak in Brazil it was observed an increase of almost 20 times the number of reported cases of microcephaly in newborn babies. There is no vaccine or approved drug available for the treatment and prevention of infections by this virus. EGCG, a polyphenol present in green tea has been shown to have an antiviral activity for many viruses. In view of the need for the development of a drug against a Brazilian strain of ZIKV, we assessed the effect of EGCG on ZIKV entry in Vero E6 cells. The drug was capable of inhibiting the virus entry by at least 1-log (>90%) at higher concentrations (>100 μM). The pre-treatment of cells with EGCG did not show any effect on virus attachment. This is the first study to demonstrate the effect of EGCG on ZIKV indicating that this drug might be possibility to be used for prevention of Zika virus infections.Laboratory of Genomic Studies Sao Paulo State University - UNESPDepartamento de Doenças Infecciosas e Parasitárias FAMERPLaboratory of Genomic Studies Sao Paulo State University - UNESPUniversidade Estadual Paulista (Unesp)FAMERPCarneiro, Bruno M. [UNESP]Batista, Mariana N. [UNESP]Braga, Ana Cláudia S. [UNESP]Nogueira, Maurício L.Rahal, Paula [UNESP]2018-12-11T17:28:43Z2018-12-11T17:28:43Z2016-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article215-218application/pdfhttp://dx.doi.org/10.1016/j.virol.2016.06.012Virology, v. 496, p. 215-218.1096-03410042-6822http://hdl.handle.net/11449/17809010.1016/j.virol.2016.06.0122-s2.0-849755275512-s2.0-84975527551.pdf79910823626712120000-0001-5693-6148Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVirology1,728info:eu-repo/semantics/openAccess2023-10-23T06:06:12Zoai:repositorio.unesp.br:11449/178090Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:41:42.964945Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The green tea molecule EGCG inhibits Zika virus entry
title The green tea molecule EGCG inhibits Zika virus entry
spellingShingle The green tea molecule EGCG inhibits Zika virus entry
Carneiro, Bruno M. [UNESP]
(-)-Epigallocatechin gallate
Antiviral
Green-tea
Zika virus
title_short The green tea molecule EGCG inhibits Zika virus entry
title_full The green tea molecule EGCG inhibits Zika virus entry
title_fullStr The green tea molecule EGCG inhibits Zika virus entry
title_full_unstemmed The green tea molecule EGCG inhibits Zika virus entry
title_sort The green tea molecule EGCG inhibits Zika virus entry
author Carneiro, Bruno M. [UNESP]
author_facet Carneiro, Bruno M. [UNESP]
Batista, Mariana N. [UNESP]
Braga, Ana Cláudia S. [UNESP]
Nogueira, Maurício L.
Rahal, Paula [UNESP]
author_role author
author2 Batista, Mariana N. [UNESP]
Braga, Ana Cláudia S. [UNESP]
Nogueira, Maurício L.
Rahal, Paula [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
FAMERP
dc.contributor.author.fl_str_mv Carneiro, Bruno M. [UNESP]
Batista, Mariana N. [UNESP]
Braga, Ana Cláudia S. [UNESP]
Nogueira, Maurício L.
Rahal, Paula [UNESP]
dc.subject.por.fl_str_mv (-)-Epigallocatechin gallate
Antiviral
Green-tea
Zika virus
topic (-)-Epigallocatechin gallate
Antiviral
Green-tea
Zika virus
description During ZIKV the outbreak in Brazil it was observed an increase of almost 20 times the number of reported cases of microcephaly in newborn babies. There is no vaccine or approved drug available for the treatment and prevention of infections by this virus. EGCG, a polyphenol present in green tea has been shown to have an antiviral activity for many viruses. In view of the need for the development of a drug against a Brazilian strain of ZIKV, we assessed the effect of EGCG on ZIKV entry in Vero E6 cells. The drug was capable of inhibiting the virus entry by at least 1-log (>90%) at higher concentrations (>100 μM). The pre-treatment of cells with EGCG did not show any effect on virus attachment. This is the first study to demonstrate the effect of EGCG on ZIKV indicating that this drug might be possibility to be used for prevention of Zika virus infections.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
2018-12-11T17:28:43Z
2018-12-11T17:28:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.virol.2016.06.012
Virology, v. 496, p. 215-218.
1096-0341
0042-6822
http://hdl.handle.net/11449/178090
10.1016/j.virol.2016.06.012
2-s2.0-84975527551
2-s2.0-84975527551.pdf
7991082362671212
0000-0001-5693-6148
url http://dx.doi.org/10.1016/j.virol.2016.06.012
http://hdl.handle.net/11449/178090
identifier_str_mv Virology, v. 496, p. 215-218.
1096-0341
0042-6822
10.1016/j.virol.2016.06.012
2-s2.0-84975527551
2-s2.0-84975527551.pdf
7991082362671212
0000-0001-5693-6148
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Virology
1,728
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 215-218
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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