The green tea molecule EGCG inhibits Zika virus entry
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.virol.2016.06.012 http://hdl.handle.net/11449/178090 |
Resumo: | During ZIKV the outbreak in Brazil it was observed an increase of almost 20 times the number of reported cases of microcephaly in newborn babies. There is no vaccine or approved drug available for the treatment and prevention of infections by this virus. EGCG, a polyphenol present in green tea has been shown to have an antiviral activity for many viruses. In view of the need for the development of a drug against a Brazilian strain of ZIKV, we assessed the effect of EGCG on ZIKV entry in Vero E6 cells. The drug was capable of inhibiting the virus entry by at least 1-log (>90%) at higher concentrations (>100 μM). The pre-treatment of cells with EGCG did not show any effect on virus attachment. This is the first study to demonstrate the effect of EGCG on ZIKV indicating that this drug might be possibility to be used for prevention of Zika virus infections. |
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The green tea molecule EGCG inhibits Zika virus entry(-)-Epigallocatechin gallateAntiviralGreen-teaZika virusDuring ZIKV the outbreak in Brazil it was observed an increase of almost 20 times the number of reported cases of microcephaly in newborn babies. There is no vaccine or approved drug available for the treatment and prevention of infections by this virus. EGCG, a polyphenol present in green tea has been shown to have an antiviral activity for many viruses. In view of the need for the development of a drug against a Brazilian strain of ZIKV, we assessed the effect of EGCG on ZIKV entry in Vero E6 cells. The drug was capable of inhibiting the virus entry by at least 1-log (>90%) at higher concentrations (>100 μM). The pre-treatment of cells with EGCG did not show any effect on virus attachment. This is the first study to demonstrate the effect of EGCG on ZIKV indicating that this drug might be possibility to be used for prevention of Zika virus infections.Laboratory of Genomic Studies Sao Paulo State University - UNESPDepartamento de Doenças Infecciosas e Parasitárias FAMERPLaboratory of Genomic Studies Sao Paulo State University - UNESPUniversidade Estadual Paulista (Unesp)FAMERPCarneiro, Bruno M. [UNESP]Batista, Mariana N. [UNESP]Braga, Ana Cláudia S. [UNESP]Nogueira, Maurício L.Rahal, Paula [UNESP]2018-12-11T17:28:43Z2018-12-11T17:28:43Z2016-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article215-218application/pdfhttp://dx.doi.org/10.1016/j.virol.2016.06.012Virology, v. 496, p. 215-218.1096-03410042-6822http://hdl.handle.net/11449/17809010.1016/j.virol.2016.06.0122-s2.0-849755275512-s2.0-84975527551.pdf79910823626712120000-0001-5693-6148Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVirology1,728info:eu-repo/semantics/openAccess2023-10-23T06:06:12Zoai:repositorio.unesp.br:11449/178090Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:41:42.964945Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The green tea molecule EGCG inhibits Zika virus entry |
title |
The green tea molecule EGCG inhibits Zika virus entry |
spellingShingle |
The green tea molecule EGCG inhibits Zika virus entry Carneiro, Bruno M. [UNESP] (-)-Epigallocatechin gallate Antiviral Green-tea Zika virus |
title_short |
The green tea molecule EGCG inhibits Zika virus entry |
title_full |
The green tea molecule EGCG inhibits Zika virus entry |
title_fullStr |
The green tea molecule EGCG inhibits Zika virus entry |
title_full_unstemmed |
The green tea molecule EGCG inhibits Zika virus entry |
title_sort |
The green tea molecule EGCG inhibits Zika virus entry |
author |
Carneiro, Bruno M. [UNESP] |
author_facet |
Carneiro, Bruno M. [UNESP] Batista, Mariana N. [UNESP] Braga, Ana Cláudia S. [UNESP] Nogueira, Maurício L. Rahal, Paula [UNESP] |
author_role |
author |
author2 |
Batista, Mariana N. [UNESP] Braga, Ana Cláudia S. [UNESP] Nogueira, Maurício L. Rahal, Paula [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) FAMERP |
dc.contributor.author.fl_str_mv |
Carneiro, Bruno M. [UNESP] Batista, Mariana N. [UNESP] Braga, Ana Cláudia S. [UNESP] Nogueira, Maurício L. Rahal, Paula [UNESP] |
dc.subject.por.fl_str_mv |
(-)-Epigallocatechin gallate Antiviral Green-tea Zika virus |
topic |
(-)-Epigallocatechin gallate Antiviral Green-tea Zika virus |
description |
During ZIKV the outbreak in Brazil it was observed an increase of almost 20 times the number of reported cases of microcephaly in newborn babies. There is no vaccine or approved drug available for the treatment and prevention of infections by this virus. EGCG, a polyphenol present in green tea has been shown to have an antiviral activity for many viruses. In view of the need for the development of a drug against a Brazilian strain of ZIKV, we assessed the effect of EGCG on ZIKV entry in Vero E6 cells. The drug was capable of inhibiting the virus entry by at least 1-log (>90%) at higher concentrations (>100 μM). The pre-treatment of cells with EGCG did not show any effect on virus attachment. This is the first study to demonstrate the effect of EGCG on ZIKV indicating that this drug might be possibility to be used for prevention of Zika virus infections. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 2018-12-11T17:28:43Z 2018-12-11T17:28:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.virol.2016.06.012 Virology, v. 496, p. 215-218. 1096-0341 0042-6822 http://hdl.handle.net/11449/178090 10.1016/j.virol.2016.06.012 2-s2.0-84975527551 2-s2.0-84975527551.pdf 7991082362671212 0000-0001-5693-6148 |
url |
http://dx.doi.org/10.1016/j.virol.2016.06.012 http://hdl.handle.net/11449/178090 |
identifier_str_mv |
Virology, v. 496, p. 215-218. 1096-0341 0042-6822 10.1016/j.virol.2016.06.012 2-s2.0-84975527551 2-s2.0-84975527551.pdf 7991082362671212 0000-0001-5693-6148 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Virology 1,728 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
215-218 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128551085408256 |