Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0206051 http://hdl.handle.net/11449/188266 |
Resumo: | Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite the effective treatment, quiescent fungi can lead to relapse, usually late, the serological diagnosis of which has been deficient. The present study was carried out with the objective of investigating a biomarker for the identification of PCM relapse and another molecule behaving as an immunological recovery biomarker; therefore, it may be used as a cure criterion. In the evolutionary analysis of the proteins identified in PCM patients, comparing those that presented with those that did not reveal relapse, 29 proteins were identified. The interactions observed between the proteins, using transferrin and haptoglobin, as the main binding protein, were strong with all the others. Patient follow-up suggests that cerulosplamin may be a marker of relapse and that transferrin and apolipoprotein A-II may contribute to the evaluation of the treatment efficacy and avoiding a premature decision. |
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Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patientsParacoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite the effective treatment, quiescent fungi can lead to relapse, usually late, the serological diagnosis of which has been deficient. The present study was carried out with the objective of investigating a biomarker for the identification of PCM relapse and another molecule behaving as an immunological recovery biomarker; therefore, it may be used as a cure criterion. In the evolutionary analysis of the proteins identified in PCM patients, comparing those that presented with those that did not reveal relapse, 29 proteins were identified. The interactions observed between the proteins, using transferrin and haptoglobin, as the main binding protein, were strong with all the others. Patient follow-up suggests that cerulosplamin may be a marker of relapse and that transferrin and apolipoprotein A-II may contribute to the evaluation of the treatment efficacy and avoiding a premature decision.National Physical LaboratoryUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de BotucatuUniversidade Federal de Mato Grosso do Sul (UFMS) Faculdade de MedicinaInstituto de Ciências Exatas e Tecnologia (ICET) Universidade Federal do Amazonas (UFAM)Laboratório Nacional de Biociências–CNPEMUniversidade Estadual Paulista (UNESP) Instituto de Biociência de BotucatuCentro de Estudos de Venenos e Animais Peçonhentos (CEVAP) UNESPUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de BotucatuUniversidade Estadual Paulista (UNESP) Instituto de Biociência de BotucatuCentro de Estudos de Venenos e Animais Peçonhentos (CEVAP) UNESPNational Physical Laboratory: 13083–970Universidade Estadual Paulista (Unesp)Universidade Federal de Mato Grosso do Sul (UFMS)Universidade Federal do Amazonas (UFAM)Laboratório Nacional de Biociências–CNPEMSylvestre, Tatiane Fernanda [UNESP]Cavalcante, Ricardo de Souza [UNESP]Silva, Julhiany de Fátima da [UNESP]Paniago, Anamaria Mello MirandaWeber, Simone SchneiderPauletti, Bianca AlvesCarvalho, Lídia Raquel de [UNESP]Santos, Lucilene Delazari dos [UNESP]Mendes, Rinaldo Poncio [UNESP]2019-10-06T16:02:36Z2019-10-06T16:02:36Z2018-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0206051PLoS ONE, v. 13, n. 10, 2018.1932-6203http://hdl.handle.net/11449/18826610.1371/journal.pone.02060512-s2.0-8505557763165078582038994153368404126695911Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS ONEinfo:eu-repo/semantics/openAccess2024-04-11T15:28:26Zoai:repositorio.unesp.br:11449/188266Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:44:41.181635Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients |
title |
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients |
spellingShingle |
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients Sylvestre, Tatiane Fernanda [UNESP] |
title_short |
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients |
title_full |
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients |
title_fullStr |
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients |
title_full_unstemmed |
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients |
title_sort |
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients |
author |
Sylvestre, Tatiane Fernanda [UNESP] |
author_facet |
Sylvestre, Tatiane Fernanda [UNESP] Cavalcante, Ricardo de Souza [UNESP] Silva, Julhiany de Fátima da [UNESP] Paniago, Anamaria Mello Miranda Weber, Simone Schneider Pauletti, Bianca Alves Carvalho, Lídia Raquel de [UNESP] Santos, Lucilene Delazari dos [UNESP] Mendes, Rinaldo Poncio [UNESP] |
author_role |
author |
author2 |
Cavalcante, Ricardo de Souza [UNESP] Silva, Julhiany de Fátima da [UNESP] Paniago, Anamaria Mello Miranda Weber, Simone Schneider Pauletti, Bianca Alves Carvalho, Lídia Raquel de [UNESP] Santos, Lucilene Delazari dos [UNESP] Mendes, Rinaldo Poncio [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Mato Grosso do Sul (UFMS) Universidade Federal do Amazonas (UFAM) Laboratório Nacional de Biociências–CNPEM |
dc.contributor.author.fl_str_mv |
Sylvestre, Tatiane Fernanda [UNESP] Cavalcante, Ricardo de Souza [UNESP] Silva, Julhiany de Fátima da [UNESP] Paniago, Anamaria Mello Miranda Weber, Simone Schneider Pauletti, Bianca Alves Carvalho, Lídia Raquel de [UNESP] Santos, Lucilene Delazari dos [UNESP] Mendes, Rinaldo Poncio [UNESP] |
description |
Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite the effective treatment, quiescent fungi can lead to relapse, usually late, the serological diagnosis of which has been deficient. The present study was carried out with the objective of investigating a biomarker for the identification of PCM relapse and another molecule behaving as an immunological recovery biomarker; therefore, it may be used as a cure criterion. In the evolutionary analysis of the proteins identified in PCM patients, comparing those that presented with those that did not reveal relapse, 29 proteins were identified. The interactions observed between the proteins, using transferrin and haptoglobin, as the main binding protein, were strong with all the others. Patient follow-up suggests that cerulosplamin may be a marker of relapse and that transferrin and apolipoprotein A-II may contribute to the evaluation of the treatment efficacy and avoiding a premature decision. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 2019-10-06T16:02:36Z 2019-10-06T16:02:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0206051 PLoS ONE, v. 13, n. 10, 2018. 1932-6203 http://hdl.handle.net/11449/188266 10.1371/journal.pone.0206051 2-s2.0-85055577631 6507858203899415 3368404126695911 |
url |
http://dx.doi.org/10.1371/journal.pone.0206051 http://hdl.handle.net/11449/188266 |
identifier_str_mv |
PLoS ONE, v. 13, n. 10, 2018. 1932-6203 10.1371/journal.pone.0206051 2-s2.0-85055577631 6507858203899415 3368404126695911 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS ONE |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129353097150464 |